Day: September 24, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

Example 6 4-(3,4-Dichloro-benzyloxy)-2-(2,6-d-oxo-piperid-n-3-yl)-isoindole-l,3-d-oneStep 1 :[179] Triethylamine (2.70 mL, 19.4 mmol) was added to a mixture of 3- hydroxyphthalic anhydride (3.00 g, 18.3 mmol) and ralphac-alpha-aminoglutarimide hydrochloride (3.01 g, 18.3 mmol) in DMF (60 mL). The reaction mixture was heated to 90 0C overnight, then cooled to room temperature and the solvent was evaporated under vacuum. The residue was stirred in CH2Cl2 (100 mL) for 30 min and the solvent was removed under vacuum. The residue was stirred in water (120 mL) for 2 h and the resulting solid was filtered, washed with water (50 mL) and dried. 1 ,4-Dioxane (200 mL) was added, and the resulting suspension was stirred for 16 h and filtered; the insoluble material was reserved. The filtrate was treated with decolorizing carbon (2 g) and heated to reflux for 1 h. After cooling to 50 0C, the reaction mixture was filtered through Celite and the filter was washed with additional 1,4-dioxane (50 mL). The filtrate was combined with the insoluble precipitate and evaporated to dryness. The resulting solid was triturated with ethyl acetate (100 mL), filtered and dried to give 2-(2,6-dioxo-piperidin-3-yl)-4-hydroxy-isoindole-l,3-dione, 4.18 g, in 56% yield; 1H NMR (DMSO-J6) delta 1.99-2.06 (m, IH), 2.45-2.61 (m, 2H), 2.82-2.96 (m, IH), 5.08 (dd, J = 12.6 Hz, J = 5.3 Hz, IH), 7.23-7.33 (m, 2H), 7.66 (dd, J = 8.2 Hz, J = 7.2 Hz, IH), 11.10 (s, IH), 11.19 (s, IH)., 37418-88-5

The synthetic route of 37418-88-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CELGENE CORPORATION; WO2008/115516; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

General procedure: A reaction vessel was charged with phthalic anhydride (1.0 mmol), alkyl acrylate (2.0 mmol), ruthenium catalyst (0.015 mmol, 9mg), Cu(OAc)2*H2O (400 mg, 2.0 mmol), and NMP (3ml) in air. The reaction vessel was then sealed and stirred at 120 C for 20 h. Then, the mixture was cooled to room temperature and diluted with ethyl acetate and washed with brine. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. The resulting residue that was purified by column chromatography using ethyl acetate-hexane (15:85) as the solvent, and then recrystallized in ethyl acetate-hexane (15:85).

32703-79-0, As the paragraph descriping shows that 32703-79-0 is playing an increasingly important role.

Reference£º
Article; Kianmehr, Ebrahim; Fardpour, Maryam; Darvish, Ali; Kharat, Ali Nemati; Weng Ng, Seik; Tetrahedron Letters; vol. 60; 10; (2019); p. 699 – 702;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-41-3,Benzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: In a 20 or 40 mL reaction vial equipped with magnetic stir bar and Teflon-lined cap, a solution of the corresponding carboxylic acid (1.5 mmol, 3.0 eq) and DMAP (183.3 mg, 1.5 mmol, 3.0 eq) in anhydrous DMF (9.0 mL) was homogenized by stirring for 5-10min. EDCI¡¤HCl (287.6mg, 1.5mmol, 3.0 eq) was added, and the resulting mixture was homogenized by stirring for 5-10 min. The corresponding 1,3-indandione (0.5mmol, 1.0 eq) was added, and the resulting mixture was resealed and stirred for 12-72h, monitoring by LCMS. When complete, workup method A, B, or C was used to isolate the final products.

496-41-3, As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

Reference£º
Article; Larsen, Brian J.; Rosano, Robert J.; Ford-Hutchinson, Thomas A.; Reitz, Allen B.; Wrobel, Jay E.; Tetrahedron; vol. 74; 22; (2018); p. 2762 – 2768;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

Compound 4 (5-bromobenzofuran, 8.5 g, 43.4 mmol),Compound 5 (4-(methoxycarbonyl)phenylboronic acid,8.6 g, 47.8 mmol) dissolved in MeOH (9.0 mL, 1 mL/g),In toluene (90.0 mL, 10 mL/g),Add Cs2CO3 (28.1g, 86.3mmol),Then fill with nitrogen. Pd(PPh3)4 (2.5 g, 2.2 mmol) was added under nitrogen,It was then stirred under reflux for 2 hours. After the reaction,The reaction was filtered through celite and concentrated.Then, by recrystallization, a white solid compound 6 (9.7 g, yield: 89percent) was obtained.

23145-07-5, 23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Dongjin Shimeiken Co., Ltd.; Cui Zhenyu; Jiang Bingnan; Yin Xingyi; Song Zhenyin; Jin Xingxie; Li Dongxuan; Cui Zhien; Li Xuanzhi; Shen Guichun; (45 pag.)CN109206387; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

143878-29-9, Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting intermediate 7 (30 g, 0.11 mol), water (150 mL),Propylene glycol monomethyl ether (36mL) and 50% sodium hydroxide solution (90mL), slowly heated to 90 C with stirring, the same temperature for 8h, the reaction was monitored by TLC. After the reaction is completed,Cooled to 5 C with ice bath and stirred for 2h, filtered with suction,The filter cake was washed with an appropriate amount of water added to 500mL single-necked flask,Water (210 mL) and propylene glycol monomethyl ether (35 mL) were added,The temperature of the reaction solution was raised to 80 C and the reaction solution became homogeneous.Dilute dilute hydrochloric acid, adjust pH to about 3, precipitated solid.After cooling to 10 C, stirring was continued for 2h. Suction filtration,The filter cake was washed with an appropriate amount of water and dried to give an off-white solid,Yield 20.8g, yield 89.8%, purity 99%, 143878-29-9

The synthetic route of 143878-29-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenyang Pharmaceutical University; Wang Shaojie; Lei Yu; Bao Li; (9 pag.)CN107337658; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

21535-97-7, 3-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Methylbenzofuran 3 (5.08 g, 38.5 mmol) is treated with SeO2 (5.10 g, 46.2 mmol) in accordance with Method D affording the title compound (3.08 g) after column chromatography (silica gel, 5% EtOAc in heptanes) as a light yellow wax: 1H NMR (360 MHz, CDCl3, deltaH) 10.19 (IH, s), 8.28 (IH, s), 8.20 (IH, dd), 7.57 (IH, dd), 7.43 (IH, app td), 7.40 (IH, app td).; Method D[00102] In accordance with the procedure of Zaidlewicz et al. (Heterocycles, 2001, 55,569-577), a suspension of the 3-methylbenzofuran (1 equiv) and SeO2 (1.2 equiv) in 1,4- dioxane (6 vol) is warmed to reflux and stirred 24 h. At this juncture, reaction progress is assessed by TLC or LC/MS. If the reaction is incomplete, a further portion of SeO2 (1.2 equiv) is added and stirring continued at reflux for a further 24 h. On completion the reaction mixture is allowed to cool to rt and filtered through Celite 521. The filter cake is washed with EtOAc (12 vol), the filtrate coned in vacuo, and the residue purified by column chromatography (silica gel, 5-40% EtOAc in heptanes) affording the desired product., 21535-97-7

21535-97-7 3-Methylbenzofuran 88939, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; WO2009/85256; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

7169-34-8, General procedure: Coumaranone (1.00 mmol) and aldehyde (1.00 mmol) were combined in a dry vial. 3.5 g of neutral alumina was then added followed by 5 mL of dichloromethane. The reaction mixture was stirred for 12 h at 25 C. The reaction mixture was then filtered and the dichloromethane layer collected and concentrated to dryness in vacuo to afford the desired aurone. Further purification was performed as noted.

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sutton, Caleb L.; Taylor, Zachary E.; Farone, Mary B.; Handy, Scott T.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 901 – 903;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23681-89-2,2,3-Dihydrobenzofuran-6-ol,as a common compound, the synthetic route is as follows.

EXAMPLE 7 275 mg. of a 55percent sodium hydride dispersion in oil are washed under nitrogen three times with absolute tetrahydrofuran and then covered with 5 ml. of absolute tetrahydrofuran. Thereafter, the mixture is cooled to 0¡ã C. and treated dropwise while stirring with a solution of 0.85 g. of 6-hydroxy-2,3-dihydrobenzofuran in 10 ml. of absolute tetrahydrofuran. The mixture is stirred for one hour at room temperature, again cooled to 0¡ã C. and 1.22 g. of 1-bromo-3,7,7-trimethyl-2,4-octadiene dissolved in 10 ml. of absolute tetrahydrofuran are added. Subsequently, the mixture is diluted with 10 ml. of absolute hexamethylphosphoric acid triamide, the ice bath removed and the mixture stirred for 2 hours. Thereafter, the mixture is poured onto ice-water and extracted three times with diethyl ether. The extracts are washed with water and saturated aqueous sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (98:2 parts by volume) there is obtained pure 6-[(3,7,7-trimethyl-2,4 -octadienyl)-oxy]-2,3-dihydrobenzofuran which is distilled in a bulb-tube at 130¡ã C./0.02 mmHg; nD20 = 1.5438.

23681-89-2, The synthetic route of 23681-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

79002-39-4, Benzofuran-5-carbonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,79002-39-4

EXAMPLE 15:PREPARATION OF 5-(5-FORMYL-I -BENZOFURAN-2-YL)-6-METHYL-4-[(4- METHYL-1 H-INDOL-5-YL)AMINO]NICOTINONITRILEStep a): Preparation of 5-formylbenzofuran.To a -150C to -2O0C solution of 1-benzofuran-5-carbonitrile (5 g, 34.9 mmol) in 50 mL of dichloromethane under nitrogen was added DIBAL-H (41.9 mL, 41.9 mmol, 1.0M in heptane) such that the temperature was less than or equal to -150C. The reaction mixture was stirred for an additional 10 min at -150C to -2O0C and quenched by adding 2.0 N HCI dropwise such that the temperature was less than or equal to room temperature. The organic layer was then separated, washed with water, dried over sodium sulfate and concentrated to give 4 g (78%) of the title compound as a yellow oil, which was used in the next step without further purification.

79002-39-4 Benzofuran-5-carbonitrile 2795184, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2009/76571; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem