With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a mixture of 2,3-dihydrobenzofuran-2-carboxylic acid (1.0 g, 6.09 mmol) in DMF (10 mL) was added NCS (976 mg, 7.31 mmol) at 25 C, and the mixture was heated to 60 C for 3 h. The reaction mixture was adjusted to pH = 5-6 by addition of iN HC1, and EtOAc was added (10 mL). The layers were separated and the aqueous phase was extracted with EtOAc (3 x 5 mL). The combined organic phases were washed with brine (5 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to provide 5 -chloro-2,3 -dihydrobenzofuran-2-carboxylic acid.
1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.
Patent; DENALI THERAPEUTICS INC.; CRAIG, Robert A., II; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; HALE, Christopher R. H.; LEXA, Katrina W.; OSIPOV, Maksim; REMARCHUCK, Travis; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (187 pag.)WO2019/32743; (2019); A1;,
Benzofuran – Wikipedia
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