Day: September 11, 2020

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound (3S) -pyrrolidin-3-yl (2R) -cyclopentyl (hydroxy) phenyl acetate (0.2 g, 0.69 mM) was dissolved in acetonitrile (5. 0ML). To the reaction mixture, 5- (2- BROMOETHYL) -2, 3-DIHYDRO-1-BENZOFURAN (0.173 G, 0.76 MM), POTASSIUM CARBONATE (0.29 G, 2.01 mM) and potassium iodide (0.23 g, 1.38 mM) were added and the reaction mixture was heated under reflux for 8 hours and then cooled to room temperature. Acetonitrile was evaporated under vacuum. The residue was partitioned between ethyl acetate (30.0 ml) and water (30.0 ml). The organic layer was washed with water and brine solution. It was dried over anhydrous NA2S04 and concentrated. The residue was purified by silica gel column chromatography using 30percent ethyl acetate in hexane to get the title compound. Yield = 46percent (0.14 g, 0.32 mM). 1;H NMR (CDCl3): delta 7.66 (D, J=1. 5 Hz, 2H), 7.28-7.36 (M, 3H), 7.05 (d, J=8 Hz, 1H), 6.94 (d, J=8 Hz, 1H), 6.71 (d, J=8 Hz, 1H), 5.20-5.23 (M, 1H), 4.52-4.58 (M, 2H), 3.80 (s, 1H), 3.18 (t, J=9 Hz, 2H), 2.70-2.92 (M, 8H), 2.50-2.70 (M, 1H), 2.04-2.15 (M, 1H), 1.25-1.61 (M, 9H)., 127264-14-6

127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; WO2004/56767; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.,59434-19-4

4-Aminoisobenzofuran-1(3H)-one (600 mg, 4 mmol), picolinaldehyde (856 mg, 8 mmol) and 1 g of MgSO4 were added into 40 mL of dichloromethane and the mixture was stirred under reflux overnight, then the mixture was evaporated under reduced pressure and the residues was dried in vacuum. 476 mg of (E)-4-(pyridin-2-ylmethyleneamino) isobenzofuran-1(3H)-one was obtained. A mixture of (E)-4-(pyridin-2-ylmethyleneamino) isobenzofuran-1(3H)-one (476 mg, 2 mmol), benzaldehyde (212 mg, 2 mmol), sodium methanolate (432 mg, 8 mmol) and ethyl propionate (40 mL) was stirred at room temperature overnight. Then the resulting mixture was evaporated under reduced pressure and extracted with ethyl acetate (100 mL¡Á4) and concentrated. The crude product was purified by column chromatography (silica gel, petroleum ether:ethyl acetate 20:1 to 5:1) to give 30 mg of methyl 4-oxo-3-phenyl-2-(pyridin-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate; yield 5%. LC-MS (ESI) m/z: 459 (M+1)+.

As the paragraph descriping shows that 59434-19-4 is playing an increasingly important role.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of amine (6) (100 mg,0.407 mmol) in ethanol was added amines (7.1-7.9) (0.407mol) followed by anhydrous sodium sulphate (0.407 mmol) and stirred at 50 C for 1 h. The hot homogenous solution was filtered and cooled to 5 C to isolate the corresponding imines (8.1-8.9) in quantitative yields.

4265-16-1, The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sreedhar, Pandiri; Srinivas, Gudipati; Raju, Rallabandi Madhusudan; Asian Journal of Chemistry; vol. 28; 7; (2016); p. 1603 – 1606;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A 50-mL round bottom flask was charged with phthalic anhydride Comppund 1a (1.1 g, 6.70 mmol) and dry toluene (30 mL). Compound 23h (2.2 g, 6.79 mmol) and triethylamine (1.2 mL, 8.61 mmol) were added to the mixture. A Dean-Stark trap was attached to the flask and the mixture was refluxed for 24 h. The mixture was cooled to room temperature, diluted with dichloromethane (200 mL), and washed with 1.0 N HCI (100 mL). The organic layer was dried using MgSC>4, filtered through Celite.(R)., and concentrated in vacuo, to give 3.1 g (98percent) of Compound 23i as a yellow solid. 1H NMR (300 MHz, CDCI3) delta 7.66-7.70 (m, 1 H), 7.52-7.57 (m, 1 H), 7.06-7.16 (m, 1 H), 6.79-6.88 (m, 3 H), 5.16-5.21 (m, 1 H),3.88 (s, 3 H), 3.85 (s, 3 H), 3.06-3.19 (m, 1 H), 2.49-2.56 (m, 1 H), 2.26-2.33 (m, 1 H), 1.46-1.56 (m, 2 H), and 1.42 (s, 9 H).

37418-88-5, As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/81995; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4- (2-Aminoethoxy) benzoic acid methyl ester hydrochloride (78.90 g, 0.340 mol) and 3- methylbenzofuran-2-carboxylic acid (60.0 g, 0.340 mol) were suspended in acetonitrile (360 ml) and cooled to 0-5 C. Pyridine (137.6 mL, 1.702 mol) was added quickly. A solution of phosphorous oxychloride (52.2 g, 0.340 mol) in acetonitrile (60 ML) was added drop wise over thirty to forty-five minutes with the temperature kept below 20 C. The reaction mixture was allowed to stir for one hour and warm slowly to ambient temperature. After completion of reaction, the solution was added to a rapidly stirred 0-5 C mixture of chlorobenzene (1000 ML) and IN hydrochloric acid (1000 ml). The reaction mixture was stirred rapidly and allowed to warm to room temperature. The organic layer was washed with water, 3% potassium hydroxide, and again with water. Chlorobenzene (100 ML) was added to the washed organic layer. Solvent (100 ML) was then distilled at atmospheric pressure until the pot temperature reached 132 C. After cooling to ambient temperature, 4- {2- [ (3-METHYLBENZOFURAN-2- carbonyl) amino] ethoxy} benzoic acid methyl ester was stored in solution for use in the next step., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Patent; AXYS PHARMACEUTICALS INC.; WO2004/92115; (2004); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-41-3,496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SOCl2 (2.38g, 20mmol) was added drop-wise to a stirringsolution of 3-chlorobenzoic acid (6b, 0.78 g, 5 mmol) inCHCl3 (10 mL) under ice-water bath, and the mixture wasrefluxed for 1 h and then was concentrated under reducedpressure to get the intermediate.The intermediate in CHCl3 was added drop-wise to a stirringsolution of 1-(m-tolyl)piperazine hydrochloride (4b,0.53 g, 2.5 mmol) and TEA (10 mmol) in CHCl3 under icewaterbath. After being refluxed for 8h, the mixture waswashed with H2O and NaHCO3 saturated solution, then driedover Na2SO4 and concentrated under reduced pressure. Thecrude material was purified by CC (petroleum ether AcEt =4:1) and was acidulated with HCl and then was recrystallizedin EtOH to give the title compound 7c as white solid (0.30 g,34.19%)

496-41-3 Benzofuran-2-carboxylic acid 10331, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Xiaoke; Sun, Haopeng; Du, Lvpei; Huang, Lu; Xu, Jing; Zhu, Yingying; Yu, Peng; Zhang, Xiaojin; Tang, Yiqun; You, Qidong; Medicinal Chemistry; vol. 10; 5; (2014); p. 497 – 505;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.,4265-16-1

To a solution of 2-benzofuran carbaldehyde (1.00 g, 6.85 mmol) in methanol (20 ml) were added hydroxylammonium chloride (530 mg, 7.63 mmol) and pyridine (2.8 ml), followed by stirring at room temperature for 6.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure. Ethyl acetate was added to the resulting residue, followed by washing sequentially with a 5% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogen carbonate solution and then a saturated aqueous sodium chloride solution. The resulting organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to afford the title compound (1.07 g) as a white solid. (Yield: 97%) 1H-NMR spectrum (CDCl3, ppm): 8.47 & 7.81 (brs, total 1H), 8.14 & 7.67 (s, total 1H), 7.69 & 6.96 (d, J=0.9Hz, total 1H), 7.67 & 7.60 (ddd, J=7.7, 1.2, 0.9Hz, total 1H), 7.55-7.49 (m, 1H), 7.43-7.22 (m, 2H).

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

Reference£º
Patent; Ube Industries, Ltd.; EP2264009; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A mixture of 3-hydroxyphthalic anhydride (1.24 g, 7.6 mmol), 2,4-dimethoxybenzylamine (1.14 mL, 7.6 mmol) and acetic acid (5 mL) was heated at 80¡ãC for 24 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (1.73 g, 73percent). 1H NMR (DMSOd6) 11.00 (1 H, s), 7.62 (1 H, dd), 7.29 (1 H, d), 7.21 (1 H, d), 6.90 (1 H, d), 6.56 (1 H, d), 6.43 (1 H, dd), 4.59 (2H, S)1 3.79 (3H, s), 3.72 (3H, s). MS: [M-H+] 314., 37418-88-5

As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.

Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; WO2008/44041; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 1 benzaldehyde (221 mg, 1.25 mmol), Preparation 12 phenol (170 mg, 1.25 mmol), K2CO3 (518 mg, 3.75 mmol), and DMF (5 mL) were combined and heated at 100¡ã C. for 24 h. The mixture was cooled to rt, poured into H2O and extracted with EtOAc (2.x.). The combined extracts were washed with 1M NaOH and brine, dried (MgSO4), filtered, concentrated, and chromatographed (loaded with CH2Cl2; eluted with 10percent EtOAc in hexanes). The isolated solid (140 mg) was dissolved in acetonitrile (10 mL) at rt. To the solution was added acetic acid (0.082 mL, 1.44 mmol) and methylamine (0.479 mL of a 2M solution in THF, 0.957 mmol). After 1 h NaBH(OAc)3 (152 mg, 0.718 mmol) was added. The mixture was stirred at rt for 3 d, poured into sat. NaHCO3 (50 mL) and 1 M NaOH (5 mL) and extracted with EtOAc (2.x.50 mL). The combined extracts were dried (MgSO4), filtered, concentrated, and chromatographed (loaded with CH2Cl2; eluted with 10percent MeOH in CH2Cl2). The resulting yellow gum was dissolved in EtOAc (3 mL) at rt and p-toluenesulfonic acid hydrate (70 mg) was added. After 14 h the mixture was filtered and the resulting solid dried under high vacuum to provide 100 mg of the above named compound as a solid. MS (M+)=308, 310. 1H NMR (400 MHz, CD3OD): delta 7.69 (d, 2, J=9.1), 7.25 (s, 1), 7.22 (d, 2, J=8.1), 6.90 (d, 1, J=6.4), 6.56 (dd, 1, J=7.9, 2.3), 6.52 (d, 1, J=2.1), 4.62 (t, 2, J=8.7), 4.27 (s, 2), 3.21 (t, 2, J=8.7), 2.76 (s, 3), 2.36 (s, 3)., 23681-89-2

23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc; US2006/58361; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

69999-16-2, 2,3-Dihydrobenzofuranyl-5-acetic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

69999-16-2, EXAMPLE 6 2-(2,3-Dihydro-5-benzofuranyl)malonic acid To a solution of diisopropylamide (20 mmole) in 50 ml of anhydrous tetrahydrofuran (THF) maintained under a nitrogen atmosphere at -40 C. is added n-butyllithium (20 mmole). The mixture is stirred for 15 minutes and then (2,3-dihydro-5-benzofuranyl)acetic acid (10 mmole) is added. The mixture is heated at 50 C. for 1 hour and then cooled to -70 C. and ethyl chloroformate (10 mmole) is added. The temperature is increased and the mixture is stirred for about 20 minutes. The mixture is poured over ice and hydrochloric acid. The aqueous phase is extracted with ether. The ether extracts are combined, dried and evaporated to give 2-(2,3-dihydro-5-benzofuranyl)malonic acid, monoethyl ester.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; Richardson-Merrell Inc.; US4229575; (1980); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem