127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound (3S) -pyrrolidin-3-yl (2R) -cyclopentyl (hydroxy) phenyl acetate (0.2 g, 0.69 mM) was dissolved in acetonitrile (5. 0ML). To the reaction mixture, 5- (2- BROMOETHYL) -2, 3-DIHYDRO-1-BENZOFURAN (0.173 G, 0.76 MM), POTASSIUM CARBONATE (0.29 G, 2.01 mM) and potassium iodide (0.23 g, 1.38 mM) were added and the reaction mixture was heated under reflux for 8 hours and then cooled to room temperature. Acetonitrile was evaporated under vacuum. The residue was partitioned between ethyl acetate (30.0 ml) and water (30.0 ml). The organic layer was washed with water and brine solution. It was dried over anhydrous NA2S04 and concentrated. The residue was purified by silica gel column chromatography using 30percent ethyl acetate in hexane to get the title compound. Yield = 46percent (0.14 g, 0.32 mM). 1;H NMR (CDCl3): delta 7.66 (D, J=1. 5 Hz, 2H), 7.28-7.36 (M, 3H), 7.05 (d, J=8 Hz, 1H), 6.94 (d, J=8 Hz, 1H), 6.71 (d, J=8 Hz, 1H), 5.20-5.23 (M, 1H), 4.52-4.58 (M, 2H), 3.80 (s, 1H), 3.18 (t, J=9 Hz, 2H), 2.70-2.92 (M, 8H), 2.50-2.70 (M, 1H), 2.04-2.15 (M, 1H), 1.25-1.61 (M, 9H)., 127264-14-6
127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.