Day: September 4, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.,59434-19-4

To a stirred mixture of 4-(trifluoromethyl)benzaldehyde (2.8 g, 16.1 mmol) and anhydrous Magnesium sulfate (16 g, 134 mmol) in anhydrous acetonitrile (200 mL) was added 4-aminoisobenzofuran-1(3H)-one (2 g, 13.4 mmol) at room temperature. After the addition, the mixture was stirred at reflux for overnight. The mixture was filtered and the cake was washed with ethyl acetate (50 mL¡Á3). The filtrate was concentrated to give crude product. The crude product was washed with petroleum ether and re-crystallized from ethyl acetate to give the title compound (2.8 g, yield: 68%). LC-MS (ESI) m/z: 306 (M+1)+

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of aniline (0.690 g, 7.41 mmol) in dichloromethane (25 mL), 3-methylbenzofuran-2-carboxylic acid (1c) (1.00 g, 5.7 mmol) was added with stirring. Then DMAP (0.116 g, 0.57 mmol) was added, followed by DCC (1.220 g, 5.9 mmol). The reaction was left to stir at room temperature for 23 h. The reaction mixture was then filtered and the filtrate washed with water (20 mL * 2), then 5% acetic acid (20 mL * 2) and again with water (20 mL * 2). The crude product was recrystallized from methanol to yield 2c as off-white crystals (0.896 g, 63%), mp 118-120 C. 1H NMR (300 MHz, CDCl3) delta 2.68 (s, 3H), 7.13-7.18 (t, J = 7.4 Hz, 1H), 7.30-7.52 (m, 5H), 7.62-7.65 (d, J = 7.57 Hz, 1H) 7.72-7.73 (d, J = 8.57 Hz, 2H), 8.35 (s, 1H). 13C NMR (300 MHz, CDCl3) delta 9.1, 111.6, 120.0, 121.1, 123.4, 123.9, 124.6, 127.5, 129.2, 129.9, 137.5, 142.4, 153.3, 158.1. MS(ESI)+ calcd for C16H14NO2 [M+H]+: 252.1025, found: 252.1027., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Article; Marriott, Karla-Sue C.; Morrison, Andrew Z.; Moore, Misty; Olubajo, Olarongbe; Stewart, Leonard E.; Bioorganic and Medicinal Chemistry; vol. 20; 23; (2012); p. 6856 – 6861;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

41019-56-1, Methyl benzofuran-4-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of LiOH (1.44 g, 34.3 mmol) in water (20 mL) wasadded to a solution of the above ester (2.02 g, 11.4 mmol) in THF(20 mL) and MeOH (20 mL) and the solution was stirred at 20 Cfor 16 h and then evaporated. The residue was dissolved in water(50 mL) and acidified with conc. HCl and the precipitate was filteredand dried to give benzofuran-4-carboxylic acid (1.83 g,99%). 1H NMR (DMSO d6) d 13.10 (s, 1H), 8.14 (d, J = 2.1 Hz, 1H),7.85-7.91 (m, 2H), 7.43 (t, J = 7.9 Hz, 1H), 7.33 (dd, J = 2.1, 1.0 Hz,1H). Found: [MH] = 161.1.

41019-56-1, 41019-56-1 Methyl benzofuran-4-carboxylate 22326486, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Conole, Daniel; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha U.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1797 – 1809;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

58546-89-7, A solution of Alloc-THP protected PBD-Py acid 14a (150 mg, 0.23 mmol, 1.0 equivalent) was dissolved in DMF. EDCI (0.46 mmol, 2.0 eq) and DMAP (0.58 mmol, 2.5 eq) were added to the stirred solution of 14a at room temperature and the mixture was allowed to stir for 30 minutes after which the benzofuran-5-amine (38.3 mg, 0.29 mmol, 1.25 eq) was added. The reaction mixture was allowed to stir for a further 3 hour at which point TLC showed completion of reaction. The reaction was quenched by pouring it onto a mixture of ice/water mixture and the resulting mixture was extracted with ethyl acetate (3 x 150 mL). The combined extracts were sequentially washed with citric acid (50 mL), saturated aqueous NaHC03 (50 mL), water (50 mL), brine (50 mL) and finally dried over MgS04. Excess ethyl acetate was evaporated by rotary evaporator under reduced pressure and the crude product was directly used in the next step without further purification. m/z (+EI) calc. for C4oH45N5010 (M)+ 755.91 found 756.76 ([M+H]+

As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.

Reference£º
Patent; UCL BUSINESS PLC; SPIROGEN SARL; HOWARD, Philip Wilson; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; TAYLOR, Peter William; WO2013/164592; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4687-25-6,4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A stirred mixture of heterocycle-carboxaldehyde 5(1.0 mmol) and p-toluene-sulfonylmethyl isocyanide (TosMIC)(1.1 mmol, 0.21 g) in 1:1 DME/MeOH (15 mL, both anhydrous) wasrefluxed with Ambersep 900(OH) ion exchange resin (2.0 g, exchangecapacity 1.18 meq/mL) for 2 h. The reaction mixture wasfiltered, the resin was washed by MeOH twice (2 5 mL), and thecombined filtrates were concentrated under reduced pressure togive the crude product, which was purified by column chromatography on silica gel (eluent: petroleum ether/acetone 4:1) to afford the pure compound 6.

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Ming-Zhi; Jia, Chen-Yang; Gu, Yu-Cheng; Mulholland, Nick; Turner, Sarah; Beattie, David; Zhang, Wei-Hua; Yang, Guang-Fu; Clough, John; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 669 – 674;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh (950 mg, 4.82 mmol)Soluble12 mL anhydrous ether and cooled to -78 ¡ã C. 1.3 M tert-butyllithium in pentane (7.85 mL, 10.2 mmol) was added dropwise to the supernatant. The reaction was stirred at -78 ¡ã C for 2 hours,DMF (0.8 mL, 10.3 mmol) and diethyl ether (1 mL). After 1 h reaction, quench with ammonium chloride at -78 ¡ã C. Ethyl acetate extraction, anhydrous sulfur Sodium sulfate dried, concentrated, and passed through a silica gel column to give a yield of 75percent., 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Shanghai University; Xu Bin; Chen Cheng; (37 pag.)CN107266413; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10242-12-3

Compound 69 (2.0 g, 9.66 mmol) and beta-alanine methylester¡¤HCl (1.752 g, 12.55 mmol) weredissolved in dimethylformamide (48.3 mL). 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(2.41 g, 12.55 mmol) and 4-dimethylaminopyridine (0.59 g, 4.83 mmol) were added and thereaction was stirred under Ar at room temperature for 2 d. An additional amount of beta-alaninemethylester¡¤HCl (337 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (462 mg), and 4-dimethylaminopyridine (147 mg) were added and stirred for an additional night. The reaction wascooled in an ice bath and then water was added to precipitate the desired compound. The solutionwas filtered to obtain compound 70 (2.82 g, 100% yield), which used without further purification.

As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Article; Reid, Emily E.; Archer, Katie E.; Shizuka, Manami; McShea, Molly A.; Maloney, Erin K.; Ab, Olga; Lanieri, Leanne; Wilhelm, Alan; Ponte, Jose F.; Yoder, Nicholas C.; Chari, Ravi V.J.; Miller, Michael L.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 17; (2019); p. 2455 – 2458;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

133720-60-2, 7-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of diisopropylamine (0.65 mL, 4.7 mmol) in THF (15 L) was cooled to 5C and n-BuLi (2.5 M in hexanes, 1.9 mL, 4.7 mmol) was added dropwise over 5 min. The mixture was stirred at 5C for 15 min and cooled to – 700C. Chlorotrimethylsilane (0.59 mL, 4.7 mmol) was added followed by a solution of 7-bromobenzofuran (0.46 g, 2.35 mmoi) in THF (5 mL). The mixture was stirred at -700C for 1.5 h and poured into sat’d aq NH4Cl (80 mL). The mixture was diluted with 5% aq HCI (20 mL) and extracted with ether (2 x 80 mL). The combined ether extracts were washed with sat’d aq NaHCO3 (50 mL), dried over MgSO4 and concentrated to leave crude 7-bromo-2-(trimethylsilyl)benzofuran (0.62 g, 98%) as a yellow oil.

133720-60-2, As the paragraph descriping shows that 133720-60-2 is playing an increasingly important role.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; WO2007/117560; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2,3-dihydro-1 -benzofuran-5-amine (33.7 mg, 0.237 mmol) and DIPEA (0.21 mL, 1 .18 mmol) in DCM (1 mL) was cooled to 0¡ãC before crude 2-chloro-benzothiazole-5-carbonyl chloride (92 mg, 0.237 mmol) dissolved in DCM (1 mL) was added. The mixture was stirred at rt for 30 min. The mixture was diluted with DCM (5 mL) and washed with water (5 mL). the organic extract was dried over Na2S04, filtered and concentrated to give the crude title compound (69 mg) as a pale yellow resin; LC-MS: tR= 0.86 min; [M+H]+= 330.97;1H NMR (400 MHz, D6-DMSO): delta 10.28 (s, 1 H), 8.56 (d, J = 1 .1 Hz, 1 H), 8.26 (d, J = 8.5 Hz, 1 H), 8.07 (dd, J, = 1 .5 Hz, J2= 8.5 Hz, 1 H), 7.70 (s, 1 H), 7.45 (dd, J, = 1 .7 Hz, J2= 8.5 Hz, 1 H), 6.76 (d, J = 8.5 Hz, 1 H), 4.54 (t, J = 8.7 Hz, 2 H), 3.21 (t, J = 8.7 Hz, 2 H).

42933-43-7, 42933-43-7 2,3-Dihydrobenzofuran-5-amine 3841102, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOLLI, Martin; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEBER, Patrick; (95 pag.)WO2016/207785; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

41717-32-2,41717-32-2, 1-Benzofuran-2-carbonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

d) preparation of methyl benzofuran-2-carboximidate hydrochloride 2-Cyanobenzofuran (10.7 g) was dissolved in ethereal HCl (150 ml, 5M) and methanol (12 ml). The resulting mixture was kept at 4 C. for 48 hours. The resulting solid was filtered, washed with ether and dried (13.4 g, 85%). 1 H-NMR (DMSO-d6): 4.30 (s,3H), 7.50 (t,1H), 7.70 (t,1H), 7.80 (d,1H), 7.90 (d,1H), 8.40 (s,1H).

The synthetic route of 41717-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Societe de Conseils de Recherches et d’Applications Scientifiques (S.C.R.A.S); US5310930; (1994); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem