With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.
58546-89-7, A solution of Alloc-THP protected PBD-Py acid 14a (150 mg, 0.23 mmol, 1.0 equivalent) was dissolved in DMF. EDCI (0.46 mmol, 2.0 eq) and DMAP (0.58 mmol, 2.5 eq) were added to the stirred solution of 14a at room temperature and the mixture was allowed to stir for 30 minutes after which the benzofuran-5-amine (38.3 mg, 0.29 mmol, 1.25 eq) was added. The reaction mixture was allowed to stir for a further 3 hour at which point TLC showed completion of reaction. The reaction was quenched by pouring it onto a mixture of ice/water mixture and the resulting mixture was extracted with ethyl acetate (3 x 150 mL). The combined extracts were sequentially washed with citric acid (50 mL), saturated aqueous NaHC03 (50 mL), water (50 mL), brine (50 mL) and finally dried over MgS04. Excess ethyl acetate was evaporated by rotary evaporator under reduced pressure and the crude product was directly used in the next step without further purification. m/z (+EI) calc. for C4oH45N5010 (M)+ 755.91 found 756.76 ([M+H]+
As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.
Reference£º
Patent; UCL BUSINESS PLC; SPIROGEN SARL; HOWARD, Philip Wilson; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; TAYLOR, Peter William; WO2013/164592; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem