42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2,3-dihydro-1 -benzofuran-5-amine (33.7 mg, 0.237 mmol) and DIPEA (0.21 mL, 1 .18 mmol) in DCM (1 mL) was cooled to 0¡ãC before crude 2-chloro-benzothiazole-5-carbonyl chloride (92 mg, 0.237 mmol) dissolved in DCM (1 mL) was added. The mixture was stirred at rt for 30 min. The mixture was diluted with DCM (5 mL) and washed with water (5 mL). the organic extract was dried over Na2S04, filtered and concentrated to give the crude title compound (69 mg) as a pale yellow resin; LC-MS: tR= 0.86 min; [M+H]+= 330.97;1H NMR (400 MHz, D6-DMSO): delta 10.28 (s, 1 H), 8.56 (d, J = 1 .1 Hz, 1 H), 8.26 (d, J = 8.5 Hz, 1 H), 8.07 (dd, J, = 1 .5 Hz, J2= 8.5 Hz, 1 H), 7.70 (s, 1 H), 7.45 (dd, J, = 1 .7 Hz, J2= 8.5 Hz, 1 H), 6.76 (d, J = 8.5 Hz, 1 H), 4.54 (t, J = 8.7 Hz, 2 H), 3.21 (t, J = 8.7 Hz, 2 H).
42933-43-7, 42933-43-7 2,3-Dihydrobenzofuran-5-amine 3841102, abenzofuran compound, is more and more widely used in various.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOLLI, Martin; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEBER, Patrick; (95 pag.)WO2016/207785; (2016); A1;,
Benzofuran – Wikipedia
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