New learning discoveries about 81742-10-1

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

81742-10-1, 4-(naphth-2-yl)-2-fluoro-1,3-dihydroxybenzene 14 (760 mg, 2.988 mmol) obtained from Example 3, anhydrous 2,5-dichlorotrimellitic acid 23 (780 mg, 2.988 mmol, PE Applied Biosystems, Foster City, CA (AB) Part No. 361892), nitrobenzene (5 mL), and aluminum chloride in nitrobenzene (15 mL, 1 M, Aldrich Chemical) were mixed and the mixture was stirred at room temperature for 16 hours. The reaction mixture was added to ice water (100 mL) and was poured into a magnetically stirred mixture of ethyl acetate (100 mL), 10% HCl (100 mL) was added, and aluminum salt was dissolved. The organic layer was washed with water (100 mL ¡Á 2) and washed with brine (100 mL ¡Á 1), dried over sodium sulfate, filtered, and the solvent was removed. The product was obtained as an isomeric mixture. The product was purified by silica gel column chromatography (silica gel,10% methanol in dichloromethane mobile phase) to obtain the desired slow moving isomer 340 mg (22%) .

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
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New learning discoveries about 641-70-3

The synthetic route of 641-70-3 has been constantly updated, and we look forward to future research findings.

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

641-70-3, Example 1. Obtaining 5-nitro-2,3-dihydrophthalazine-1,4-dione A glass flask of the volume 1 I provided with an agitator, a thermometer, a condenser and a capillary was filled with 600 ml of icy acetic acid and 154.5 g (0.8 mole) of 3-nitrophthalic acid anhydride, thereafter it was heated to the temperature of 11O0C and gradually 44.1 g (0.88 mole) of hydrazine hydrate was added. Next the reaction mixture was kept at the state of boiling for 30 minutes thereafter it was cooled to the temperature of 8O0C, the crystals of 5-nitro-2,3-dihydrophthalazine-1 ,4-dione were filtered, the sediment was washed on a filter with 50 ml of acetic acid and two times with 40 ml of distilled water. The total amount of 5-nitro-2,3-dihydrophthalazine- 1 ,4-dione was 228.7 g, the yield was 92%.

The synthetic route of 641-70-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABIDOPHARMA PL SP. Z.O.O; ABIDOV, Admir, Musaevich; ISHMURATOV, Aleksei Silantievich; VILKIN, Vitalij; DANILOVA, lrina Georgievna; WO2010/82858; (2010); A2;,
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Brief introduction of 10242-12-3

10242-12-3, The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Compound 1 (300 mg) and HATU (551 mg) were dissolved in DMF (10 mL),DIEA (561 mg) was added dropwise thereto, and after stirring at room temperature for 15 minutes,Dimethylamine (2.2 mL, 2.0 M in THF) was then added to the reaction system.Stir for 20 hours at room temperature, dilute with saturated ammonium chloride solution, extract with ethyl acetate,The combined organic phases were dried over anhydrous sodium sulfate, the solvent was removed under reduced pressure,The obtained residue 2 (crude, 320 mg) was used directly in the next reaction.

10242-12-3, The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Hongyi Biological Technology Co., Ltd.; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Wu Rongguang; Li Jia; Yi Dewu; Zhou Yubo; Ye Wei; Wang Peipei; Xiang Junfeng; Zhang Kaixiang; Hu Xiaobei; (61 pag.)CN110872296; (2020); A;,
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Simple exploration of 57319-65-0

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57319-65-0, A solution of NaNO2 (2.2 g, 0.040 mol) in H2O (22 mL) was added to a mixture of 6-aminoisobenzofuran-1(3H)-one (5.0 g, 0.030 mol) in HBr (70 mL, 48%) over 5 min at 0 C. The mixture was stirred for 20 minutes before it was pipetted into an ice cold solution of CuBr (22 g, 0.21 mol) in HBr (48%, 23 mL). The resulting dark brown mixture was stirred for 20 min and was then diluted with H2O (200 mL) to produce an orange precipitate. The precipitate was filtered off, treated with sat. NaHCO3 solution, and extracted with EtOAc (20 mL*3). The organics were dried over Na2SO4 and evaporated in vacuo to give 6-bromoisobenzofuran-1(3H)-one (5.4 g, 84%). 1H NMR (300 MHz, CDCl3) delta 8.05 (d, J=1.8, 1H), 7.80 (dd, J=8.1, 1.8, 1H), 7.39 (d, J=8.1, 1H), 5.28 (s, 2H).

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; Van Goor, Fredrick F.; Burton, William Lawrence; US2015/231142; (2015); A1;,
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Some tips on 77095-51-3

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77095-51-3, Benzofuran-6-carboxylic acid (50.0 g, 0.308 moles), toluene and a catalytic amount of dimethyl formamide (DMF) are added, in sequence, to a reactor in N2 atmosphere. The suspension is heated under stirring to 55¡À5C. SOCl2 (0.370 moles) dissolved in toluene is added slowly, maintaining the temperature at 55¡À5C until conversion is complete. The solution is then concentrated under vacuum until an almost solid yellow residue is obtained. Residue = 55.6 g, molar yield = quantitative. ?HNMR (300MHz, CDC13): d 8.32 (s,lH), 8.01 (dd,l H,J;=8.3 l Hz J2=l .34Hz), 7.87 (d, 1 H, =2.08 Hz), 7.69 (d, 1 H, J=8.31 Hz), 6.88 (br d, 1 H).

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

Reference£º
Patent; OLON S.P.A.; BERTOLINI, Giorgio; FELICIANI, Lazzaro; LONGONI, Davide; SADA, Mara; VALLI, Matteo; (22 pag.)WO2019/239364; (2019); A1;,
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Analyzing the synthesis route of 4265-16-1

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ku-76 in the above reaction formula was synthesized as follows (a in the reaction formula).A THF solution (15 mL) of ethyl 2- (bis (2-isopropylphenoxy) phosphoryl) acetate (4.3 g, 10.7 mmol) was cooled to -78 degrees under an argon atmosphere, and Triton B (5.5 mL, 14.0 mmol) was added. .After stirring for 20 minutes, a THF solution (10 mL) of cinnamic aldehyde (1.32 g, 10.0 mmol) was added.After 1 hour, saturated aqueous ammonium chloride solution was added to the reaction, and the mixture was extracted with ethyl acetate (50 mL ¡Á 3). The organic layer was washed with saturated brine, dried over magnesium sulfate, and the reduced pressure solvent was distilled off.The crude product was produced by silica gel column chromatography (ethyl acetate in hexane, 3% to 5%) to give 1.57 g (78%, Z: E = 85: 15) of ester ku-76 as a pale yellow oil ., 4265-16-1

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

Reference£º
Patent; Tokyo University of Agriculture and Technology; Fujii, Yoshiharu; Wasano, Naoya; Tamura, Naoyuki; Shindo, Mitsuru; Matsumoto, Kenji; (51 pag.)JP2019/189648; (2019); A;,
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Simple exploration of 35700-40-4

The synthetic route of 35700-40-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

[00323] 2,3-Dihydrobenzofuran-7-carboxylic acid (820 mg, 5 mmol) was dissolved inTHF (10 mL). To the solution was added TEA (0.7 mL, 5 mmol) and methylchloroformate (0.43 mL, 5 mmol). The solution was stirred for 0.5 hour. The white precipitates were removed by filtration, the filtrate was added to a solution OfNaBH4 (437 mg, 12.5 mmol) in H2O (5 mL). The resulting solution was stirred overnight. The reaction mixture was neutralized with 2 M aqueous HCl solution and then extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The crude alcohol was dissolved in DCM. To the solution was added PCC (1.83 g, 7.5 mmol). The mixture was stirred for 2 hours at room temperature and diluted with diethyl ether, then ether layers were decanted. Combined organic layer was filtered though a layer of Celite. The filtrate was concentrated to give crude product. The crude was purified from column EPO with 10% EtOAc/hexane to afford 450 mg of 2,3-dihydrobenzofuran-7-carbaldehyde as a slightly yellow solid. HPLC 4.3 min., 35700-40-4

The synthetic route of 35700-40-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/25307; (2007); A2;,
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New learning discoveries about 4265-25-2

4265-25-2, 4265-25-2 2-Methylbenzofuran 20263, abenzofuran compound, is more and more widely used in various fields.

4265-25-2, 2-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-substituted benzofurans (0.5 mmol), aryl sulfonyl chloride (0.6 mmol), PPh3 (262 mg, 1.0 mmol), KI (17 mg, 0.1 mmol) or KI (42 mg, 0.25 mmol) and EtOH (1.0 mL) were mixed in a sealed tube. The mixture was stirred at 90 C or 100 C for 12 hours or 24 hours. Then, the solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to afford the pure product.

4265-25-2, 4265-25-2 2-Methylbenzofuran 20263, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Xia; Lu, Xiaoyu; Wei, Aoqi; Jia, Xiaoliang; Chen, Jun; Lu, Kui; Tetrahedron Letters; vol. 57; 48; (2016); p. 5330 – 5333;,
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Simple exploration of 652-39-1

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A mixture of 3-fluorophthalic anhydride (1 equiv.), 7-amino-2-oxa-6-thia-5- azaspiro[3.5]nonane 6,6-dioxide (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid isstirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved in DCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2SO4) and concentrated to provide 4-fluoro-6? -oxetano-2? -sulfonyl-thalidomide.

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; HE, Minsheng; MICHAEL, Ryan, E.; (768 pag.)WO2017/197055; (2017); A1;,
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Analyzing the synthesis route of 10242-12-3

10242-12-3, The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ethyl 5-nitro-1-benzofuran-2-carboxylate (2.0 g, 8.54 mmol) was suspended in a mixed solvent of methanol (3.2 mL) and THF (3.2 mL), then a 4 mol/L aqueous solution of sodium hydroxide (3.2 mL) was added thereto, and the mixture was stirred at 70C for 1 hour. A 1 mol/L aqueous solution of hydrochloric acid was added to the reaction solution, followed by extraction with ethyl acetate twice. The organic layer was washed with a saturated saline solution, dried over anhydrous sodium sulfate and filtered, and then the solvent was concentrated under reduced pressure to obtain a crude product. The obtained crude product was dissolved in DMF (20 mL), then 1,1-di-tert-butoxy-N,N-dimethylmethaneamide (13.9 g, 68.32 mmol) was added, and the mixture was stirred at 80C for 11 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was washed with a saturated saline solution, dried over anhydrous sodium sulfate and filtered, and then the organic layer was concentrated under reduced pressure to obtain a crude product. Chloroform (10 mL) was added to the obtained crude product, and the crystal was filtered out to obtain the title compound (1.76 g, 78%). 1H NMR (CDCl3, 300 MHz) delta 12.43 (s, 1H), 8.13-8.11 (m, 1H), 7.61-7.59 (m, 1H), 7.34 (s, 1H), 2.11-1.98 (m, 4H), 1.64-1.59 (m, 9H).

10242-12-3, The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Dainippon Pharma Co., Ltd.; IKUMA Yohei; FUKUDA Nobuhisa; IWATA Masato; KIMURA Hidenori; SUZUKI Kuniko; EP2876105; (2015); A1;,
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