Analyzing the synthesis route of 87-41-2

87-41-2 Isobenzofuran-1(3H)-one 6885, abenzofuran compound, is more and more widely used in various fields.

87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3H-Isobenzofuran-1-one (4.00 g, 29.8 mmol) was dissolved in concentrated sulfuric acid (5.0 ml) at 0 C., and a solution of potassium nitrate (3.0 g, 30 mmol) in concentrated sulfuric acid (8.0 ml) was added dropwise thereto. After stirring at room temperature for 5 hours, the reaction solution was diluted with water. The precipitated solid was filtered and recrystallized from ethanol (20 ml) to obtain the title compound (2.0 g, 37%). [1323] 1H NMR (400 MHz, DMSO-d6): delta 8.62-8.59 (m, 1H), 8.53 (d, J=2.8 Hz, 1H), 7.72 (d, J=8.0 Hz, 1H), 5.57 (s, 2H), 87-41-2

87-41-2 Isobenzofuran-1(3H)-one 6885, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; AJINOMOTO CO., LTD.; Ueno, Hirokazu; Yamamoto, Takashi; Takashita, Ryuta; Yokoyama, Ryohei; Sugiura, Toshihiko; Kageyama, Shunsuke; Ando, Ayatoshi; Eda, Hiroyuki; Eviryanti, Agung; Miyazawa, Tomoko; Kirihara, Aya; Tanabe, Itsuya; Nakamura, Tarou; Noguchi, Misato; Shuto, Manami; Sugiki, Masayuki; Dohi, Mizuki; US2015/51395; (2015); A1;,
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Downstream synthetic route of 10035-16-2

As the paragraph descriping shows that 10035-16-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10035-16-2,Benzofuran-5-carbaldehyde,as a common compound, the synthetic route is as follows.

To a solution of aidehyde (400g) in ether (1 Oml) was added LiN (TMS) 2 (1 M in THF, 3. 3ml) at 0C dropwise. The solution was stirred at 0C for 30min and EtMgBr (3M in THF, 1. 83moi) was added dropwise. The reaction was refluxed overnight, cooed to 0C, quenched with saturated ammonium chloride and extracted with ether. The ether was stirred with 3N HCI (20ml), then the aqueous layer was basified with NaOH pellets and extracted with ether. The ether layer was washed with brine, dried with MgS04, filtered and concentrated in vacuo to give 220mg of product (46%)., 10035-16-2

As the paragraph descriping shows that 10035-16-2 is playing an increasingly important role.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
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Downstream synthetic route of 10242-11-2

As the paragraph descriping shows that 10242-11-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-11-2,5-Bromobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 6 2-(5-bromobenzofuran-2-yl)imidazole hydrochloride R1 =H R2 =5-bromo This was prepared from 5-bromobenzofuran-2-carboxylic acid according to the methods a-e as described in example 1; m.p.=280 C. 1 H-NMR (DMSO-d6): 7.65 (dd,1H), 7.75 (d,1H), 7.85 (s,2H), 8.10 (s,1H), 8.15 (d,1H). 13 C-NMR (DMSO-d6): 109.3, 114.1, 117.1, 121.6, 125.8, 129.9, 130.3, 135.0, 142.5, 154.0., 10242-11-2

As the paragraph descriping shows that 10242-11-2 is playing an increasingly important role.

Reference£º
Patent; Societe de Conseils de Recherches et d’Applications Scientifiques (S.C.R.A.S); US5310930; (1994); A;,
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Brief introduction of 174775-48-5

Big data shows that 174775-48-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

Example-4: preparation of ethyl 5-(l-piperazinyl)-benzofuran-2-carboxylate hydrobromide. ethyl-5 -amino- l-benzofuran-2-carboxylate obtained in above step was dissolved in o-Xylene (1500ml) and then Bis (2-chloroethyl) amine hydrochloride (1 13.8g), Potassium carbonate powder (108.6g) and TBAB (5.0g) at 20-30C was added in the reaction mixture. The reaction mixture was maintained for 32 hrs at 135-140C. After completion of the reaction solid was filtered and washed it with o-Xylene [100ml *3], suck it dry. The wet cake was charged in the saturated brine solution under stirring and ammonia solution (100ml) was added in the reaction mixture at 10- 15C under stirring. The product was extracted in MDC (1000ml) and washed subsequently with dilute acetic acid and water. Aqueous HBr was charged in MDC layer and then MDC was removed atmospherically up-to 50C. Ethanol (700ml) was charged to the residue and raise the temperature of the suspension to 55-60C. The reaction mass was cooled for 1-2 hours at 20-30C and filtered the solid, washed it with Ethanol [100ml x3]. Dried at 55-60C for 12 hours. Yield: 81.3%, 174775-48-5

Big data shows that 174775-48-5 is playing an increasingly important role.

Reference£º
Patent; ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur; WO2013/153492; (2013); A2;,
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Simple exploration of 32703-79-0

The synthetic route of 32703-79-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

Into a 500 ml three-necked flask, 36 g (176 mmole) of 4-t-butylphthalic anhydride, 27 g (200 mmole) of t-butylbenzene and 100 ml of dichloroethane were placed under a stream of argon and cooled to 0C. To the obtained mixture, 56 g (420 mmole) of aluminum chloride was slowly added. After the addition was completed, the resultant mixture was stirred at the room temperature for one night. After the reaction was completed, ice was added slowly, and then concentrated hydrochloric acid was added. The formed precipitates were separated by filtration and washed well with water, and 32 g of the benzoic acid compound of the object compound was obtained (the yield: 54%; a white powder)., 32703-79-0

The synthetic route of 32703-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IDEMITSU KOSAN CO., LTD.; EP1440959; (2004); A1;,
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Downstream synthetic route of 77095-51-3

The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.77095-51-3,Benzofuran-6-carboxylic acid,as a common compound, the synthetic route is as follows.

77095-51-3, l-benzofuran-6-carboxylic acid (10 g), HOBt (12.5 g) and EDC.HC1 (17.75 g) was charged in THF (60 ml). To this solution was added di isopropyl ethyl amine (22.2 g). Reaction mass was cooled to 0~5C. Added (S)-2-(5,7-dichloro-l,2,3,4- tetrahydroisoquinoline-6-carboxamido)-3-(3-(methyl sulfonyl)phenyl)propanoic acid ( 28.5g) lot wise at -10C. Temperature of reaction mass was raised to room temperature. Stirred and monitored the reaction by TLC. After completion of reaction, Water (100 ml) and MDC (100 ml) were added. Stirred and separated the layers. Organic layer so obtained was washed with brine and 10% sodium carbonate solution. Organic layer was distilled to give crude lifitegrast which was then purified in acetone and methanol to give pure lifitegrast (3.1.2 g, 83.8%).

The synthetic route of 77095-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MANKIND PHARMA LTD.; BHAVSAR, Jigar Tarun Kumar; TIWARI, Rakesh; BHASHKAR, Bhuwan; KUMAR, Anil; (30 pag.)WO2019/73325; (2019); A1;,
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Some tips on 54109-03-4

The synthetic route of 54109-03-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54109-03-4,5-Chloroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,54109-03-4

a) 5-Chloro-1,3-dihydro-2-benzofuran-1-ol To a solution of 5-chlorophthalide (3.64 g, 21.6 mmol) in dichloromethane (100 mL) at -78¡ã C. was added di-isobutylaluminium hydride (1M in toluene) (23.8 mL, 23.8 mmol) dropwise. After 1 h the reaction mixture was quenched with a saturated solution of sodium tartrate (250 mL), allowed to warm to room temperature and stirred for 1h. The layers were separated and the aqueous layer extracted with dichloromethane. The combined organic layers were dried (MgSO4), filtered and concentrated in vacuo to yield the title compound as a white solid.

The synthetic route of 54109-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn; US2004/122001; (2004); A1;,
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Simple exploration of 54008-77-4

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54008-77-4, Under the protection of nitrogen, are weighing 30 g raw material C (177 mmol), 34.9 g raw material G (177 mmol), 42.6 g sodium tert-butanol (443 mmol), 0.40 g Pd (OAc)2(1.77 Mmol), 1.55 g C10104 R3 (3.54 mmol), dimethyl benzene is used for stirring and mixing, heating to 120 – 130 C, reflux reaction 5 – 7 hours, sampling TLC detection display without material remaining C; natural cooling to room temperature, water washing, over silica gel column, for refining THF, and dried to obtain the 31.6 g intermediate E, yield: 62.5%, HPLC: 99.9%. C raw material, the raw material G, […] molar ratio of 1:1: 2.5.

The synthetic route of 54008-77-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yantai Jiu Mu Chemicals Co., Ltd.; Chi Shenghua; Fang Pinglei; Zhang Shicai; Cui Lisha; Cheng Daxing; Liu Kai; (27 pag.)CN109369420; (2019); A;,
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New learning discoveries about 16859-59-9

16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16859-59-9,3-Hydroxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 3-aminothienopyridine 1a (1.21 g, 4.3 mmol), ortho-formylbenzoic acid (0.77 g, 5.0 mmol), and p-TsOH (20 mg) was refluxed in toluene (30 ml) for 6-7 h. Cooling of the reaction mixture to room temperature gave a precipitate that was filtered off and recrystallized from EtOH. Yield 1.24 g (70%), yellow crystals., 16859-59-9

16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Vasilin; Lukina; Stroganova; Krapivin; Chemistry of Heterocyclic Compounds; vol. 50; 10; (2015); p. 1486 – 1494; Khim. Geterotsikl. Soedin.; 10; (2014); p. 1614 – 1623,10;,
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Downstream synthetic route of 4687-25-6

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

4687-25-6,4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 9Syntheses of N-benzofuran-3-yl-methylidene-N’-(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1.2-b]pyridazin-6-yl)-hydrazine (Compound 9)6-Chloro-8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b] pyridazine (65.6mg, 0.208mol) was dissolved in N-methylpyrrolidone (2mL).Potassium carbonate (57.5mg, 0.416mmol) and hydrazine monohydrate (101 muL, 2.08mmol) were added thereto and stirred in a sealed tube at 150¡ãC for 2 hours.Thus obtained reaction liquid was diluted with water and extracted with an ethyl acetate.The extract together with the extraction liquid was dried with anhydrous sodium sulfate, and then the solvent was removed therefrom.The obtained residue was dissolved in ethanol (3mL), and benzofuran-3-carboxyaldehyde (30.4mg, 0.208mmol) was added thereto and stirred at room temperature for 3 hours.Then, the reaction liquid was filtered, and the obtained solid material was washed with diethyl ether to obtain a title compound (37.2mg, 41percent).The characteristic value of the compound is shown below.1H-NMR (300 MHz, DMSO): delta 3.87-3.89 (m, 4H), 3.98-4.00 (m, 4H), 6.50 (s, 1H), 7.40-7.43 (m, 2H), 7.64 (m, 1H), 7.88 (d, 2H, J=6.2 Hz), 8.21-8.24 (m, 2H), 8.37 (s, 1H), 8.57 (d, 2H, J=6.2 Hz), 8.59 (s, 1H), 11.03 (s, 1H); MS (ESI) m/z 440 (M+H)+.

The synthetic route of 4687-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AJINOMOTO CO., INC.; EP2518072; (2012); A1;,
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