Category: 10242-11-2

10242-11-2, Name is 5-Bromobenzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. Formula: C9H5BrO3In an article, once mentioned the new application about 10242-11-2.

Small-molecule inhibitors that target bromodomains outside of the bromodomain and extra-terminal (BET) sub-family are lacking. Here, we describe highly potent and selective ligands for the bromodomain module of the human lysine acetyl transferase CBP/p300, developed from a series of 5-isoxazolyl-benzimidazoles. Our starting point was a fragment hit, which was optimized into a more potent and selective lead using parallel synthesis employing Suzuki couplings, benzimidazole-forming reactions, and reductive aminations. The selectivity of the lead compound against other bromodomain family members was investigated using a thermal stability assay, which revealed some inhibition of the structurally related BET family members. To address the BET selectivity issue, X-ray crystal structures of the lead compound bound to the CREB binding protein (CBP) and the first bromodomain of BRD4 (BRD4(1)) were used to guide the design of more selective compounds. The crystal structures obtained revealed two distinct binding modes. By varying the aryl substitution pattern and developing conformationally constrained analogues, selectivity for CBP over BRD4(1) was increased. The optimized compound is highly potent (K d = 21 nM) and selective, displaying 40-fold selectivity over BRD4(1). Cellular activity was demonstrated using fluorescence recovery after photo-bleaching (FRAP) and a p53 reporter assay. The optimized compounds are cell-active and have nanomolar affinity for CBP/p300; therefore, they should be useful in studies investigating the biological roles of CBP and p300 and to validate the CBP and p300 bromodomains as therapeutic targets.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3923O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 5-Bromobenzofuran-2-carboxylic acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 10242-11-2, name is 5-Bromobenzofuran-2-carboxylic acid. In an article，Which mentioned a new discovery about 10242-11-2

Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bisbenzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the compounds had MICs at which 80% of the strains were inhibited (MIC80s) comparable to those of amphotericin B and fluconazole. Unlike fluconazole, many of these compounds were found to have potent fungicidal activity. The most potent compound against C. albicans had an MIC80 of ?0.09 mug/ml, and the most potent compound against C. neoformans had an MIC80 of 0.19 mug/ml. Selected compounds were also found to be active against Aspergillus fumigatus, Fusarium solani, Candida species other than C. albicans, and fluconazole-resistant strains of C. albicans and C. neoformans. It is clear from the data presented here that further studies on the structure-activity relationships, mechanisms of action and toxicities, and in vivo efficacies of these compounds are warranted to determine their clinical potential.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10242-11-2, help many people in the next few years.Recommanded Product: 5-Bromobenzofuran-2-carboxylic acid

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3919O – PubChem

Electric Literature of 10242-11-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10242-11-2, Name is 5-Bromobenzofuran-2-carboxylic acid, molecular formula is C9H5BrO3. In a Patent，once mentioned of 10242-11-2

The invention discloses a method for preparing a vilazodone intermediate 5-piperazinyl-2-acyl substituted benzofuran. By the method, a corresponding vilazodone intermediate 5-piperazinyl-2-acyl substituted benzofuran is obtained by performing a coupling reaction on 5-halogen-substituted-2-acyl substituted benzofuran and piperazine under the actions of copper serving as a catalyst and a suitable solvent. The invention provides a new method for preparing the vilazodone intermediate 5-piperazinyl-2-acyl substituted benzofuran, has the advantages of short course, conveniences in synthesis, high yield, low cost and the like, and is suitable for industrial production.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10242-11-2, and how the biochemistry of the body works.Electric Literature of 10242-11-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3914O – PubChem

Synthetic Route of 10242-11-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 10242-11-2, Name is 5-Bromobenzofuran-2-carboxylic acid,introducing its new discovery.

The C-H bond carboxylation of various aromatic compounds with CO2 was achieved by the deprotonative alumination with a mixed alkyl amido lithium aluminate compound iBu3Al(TMP)Li followed by the NHC-copper-catalyzed carboxylation of the resulting arylaluminum species, which afforded the corresponding carboxylation products in high yield and high selectivity. In addition to benzene derivatives, heteroarenes such as benzofuran, benzothiophene, and indole derivatives are also suitable substrates. Functional groups such as Cl, Br, I, vinyl, amide, and CN could survive the reaction conditions. Some key reaction intermediates such as the copper aryl and isobutyl complexes and their carboxylation products were isolated and structurally characterized by X-ray crystallographic analyses, thus offering important information on the reaction mechanism.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10242-11-2, and how the biochemistry of the body works.Synthetic Route of 10242-11-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3930O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C9H5BrO3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 10242-11-2, name is 5-Bromobenzofuran-2-carboxylic acid. In an article，Which mentioned a new discovery about 10242-11-2

no abstract published

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10242-11-2, help many people in the next few years.Computed Properties of C9H5BrO3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3902O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 5-Bromobenzofuran-2-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 10242-11-2, Name is 5-Bromobenzofuran-2-carboxylic acid, molecular formula is C9H5BrO3

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of 5-Bromobenzofuran-2-carboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10242-11-2, in my other articles.

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3901O – PubChem

10242-11-2, Name is 5-Bromobenzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. Formula: C9H5BrO3In an article, once mentioned the new application about 10242-11-2.

A novel method for the catalytic asymmetric dearomatization by visible-light-activated [2+2] photocycloaddition with benzofurans and one example of a benzothiophene is reported, thereby providing chiral tricyclic structures with up to four stereocenters including quaternary stereocenters. The benzofurans and the benzothiophene are functionalized at the 2-position with a chelating N-acylpyrazole moiety which permits the coordination of a visible-light-activatable chiral-at-rhodium Lewis acid catalyst. Computational molecular modeling revealed the origin of the unusual regioselectivity and identified the heteroatom in the heterocycle to be key for the regiocontrol.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3926O – PubChem