Tag: 241.04

The synthesis and transition temperatures of 5-(4-alkyl- and 4-alkoxy-phenyl)-2-cyanobenzo[b]furans and a 5-(4′-alkylbiphenyl-4-yl)-2-cyanobenzo[b]furan: a comparison with their biphenyl and terphenyl analogues was written by Friedman, Mark R.;Toyne, Kenneth J.;Goodby, John W.;Hird, Michael. And the article was included in Liquid Crystals in 2001.Synthetic Route of C9H5BrO3 This article mentions the following:

The synthesis and transition temperatures of 5-(4-alkyl- and 4-alkoxy-phenyl)-2-cyanobenzo[b]furans and a 5-(4′-alkylbiphenyl-4-yl)-2-cyanobenzo[b]furan are presented. The 2-cyanobenzo[b]furans show similar mesophase types to the analogous biphenyl and terphenyl compounds, which were obtained by replacing the benzo[b]furan unit with a Ph ring. The transition temperatures for the 2-cyanobenzo[b]furan compounds are always higher than for their biphenyl and terphenyl counterparts, but they are much lower than for the corresponding phenylnaphthalenes. Five mesogenic benzo[b]furans without a cyano group were prepared as intermediates and these compounds have lower clearing points than their biphenyl analogs. In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2Synthetic Route of C9H5BrO3).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C9H5BrO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor was written by Yuan, Xi;Yao, Jian-Fei;Tang, Zhen-Yu. And the article was included in Organic Letters in 2017.COA of Formula: C9H5BrO3 This article mentions the following:

A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li₂CO₃ as base at low temperature In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2COA of Formula: C9H5BrO3).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C9H5BrO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Benzofuran-oxadiazole hybrids: design, synthesis and antimicrobial activity studies was written by Sanjeeva, P.;Subba, Rao B.;Kamala, Prasad V.;Venkata, Ramana P.. And the article was included in Research Journal of Chemistry and Environment in 2021.SDS of cas: 10242-11-2 This article mentions the following:

The six benzofuran-oxadiazole derivatives I [R = ClH₂C, BrH₂C, C₆H₅, etc.] were designed, synthesized, characterized and evaluated for antimicrobial activity. The key synthetic intermediate 5-bromo-N’-hydroxybenzofuran-2-carboxamidine was prepared from 5-bromobenzofuran-2-carboxylic acid in two consecutive steps involving reaction with NaN₃, in presence of TEA, Xtalfluor-E, PPh₃ in dry DCM at 0°C followed by the treatment of resulting carbonitrile with hydroxylamine hydrochloride in presence of sodium methoxide under reflux in aqueous ethanol. Reaction of carboxamidine with different aryl esters in presence of K²CO₃ under reflux conditions in toluene afforded 3-(5-bromobenzofuran-2-yl)-5-substituted phenyl-1,2,4-oxadiazoles I [R = C₆H₅, 2-HOC₆H₄, 4-ClC₆H₄, 4-pyridinyl] while the refluxion of a solution of carboxamidine in dichloromethane with chloro/bromo acetyl chloride in presence of TEA and a catalytic amount of HBTU furnished I [R = ClH₂C, BrH₂C]. In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2SDS of cas: 10242-11-2).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.SDS of cas: 10242-11-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem