Discovery of Desmuramylpeptide NOD2 Agonists with Single-Digit Nanomolar Potency was written by Guzelj, Samo;Bizjak, Spela;Jakopin, Ziga. And the article was included in ACS Medicinal Chemistry Letters in 2022.HPLC of Formula: 10242-11-2 This article mentions the following:
The innate immune receptor nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) represents an important target for the development of structurally defined small mol. immunomodulatory compounds that have great potential to be used either as vaccine adjuvants or as general immunostimulatory agents. We report here the investigation of the structure-activity relationship of a series of novel desmuramylpeptide NOD2 agonists. Extensive exploration of chem. space culminated in the discovery of a lipophilic adamantane-moiety-featuring compound 40, the first single-digit nanomolar and the most potent NOD2 agonist in its structural class to date. Moreover, 40 acted synergistically with lipopolysaccharide and interferon-γ to induce the production of cytokines in human peripheral blood mononuclear cells and enhance their nonspecific cytotoxic activity against K562 cancer cells. These findings provide initial insight into its immunostimulatory potential, especially when used in combination with other immunopotentiators. In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2HPLC of Formula: 10242-11-2).
5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.HPLC of Formula: 10242-11-2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem