Benzofuran-oxadiazole hybrids: design, synthesis and antimicrobial activity studies was written by Sanjeeva, P.;Subba, Rao B.;Kamala, Prasad V.;Venkata, Ramana P.. And the article was included in Research Journal of Chemistry and Environment in 2021.SDS of cas: 10242-11-2 This article mentions the following:
The six benzofuran-oxadiazole derivatives I [R = ClH2C, BrH2C, C6H5, etc.] were designed, synthesized, characterized and evaluated for antimicrobial activity. The key synthetic intermediate 5-bromo-N’-hydroxybenzofuran-2-carboxamidine was prepared from 5-bromobenzofuran-2-carboxylic acid in two consecutive steps involving reaction with NaN3, in presence of TEA, Xtalfluor-E, PPh3 in dry DCM at 0°C followed by the treatment of resulting carbonitrile with hydroxylamine hydrochloride in presence of sodium methoxide under reflux in aqueous ethanol. Reaction of carboxamidine with different aryl esters in presence of K2CO3 under reflux conditions in toluene afforded 3-(5-bromobenzofuran-2-yl)-5-substituted phenyl-1,2,4-oxadiazoles I [R = C6H5, 2-HOC6H4, 4-ClC6H4, 4-pyridinyl] while the refluxion of a solution of carboxamidine in dichloromethane with chloro/bromo acetyl chloride in presence of TEA and a catalytic amount of HBTU furnished I [R = ClH2C, BrH2C]. In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2SDS of cas: 10242-11-2).
5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.SDS of cas: 10242-11-2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem