With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.
Example-4: preparation of ethyl 5-(l-piperazinyl)-benzofuran-2-carboxylate hydrobromide. ethyl-5 -amino- l-benzofuran-2-carboxylate obtained in above step was dissolved in o-Xylene (1500ml) and then Bis (2-chloroethyl) amine hydrochloride (1 13.8g), Potassium carbonate powder (108.6g) and TBAB (5.0g) at 20-30C was added in the reaction mixture. The reaction mixture was maintained for 32 hrs at 135-140C. After completion of the reaction solid was filtered and washed it with o-Xylene [100ml *3], suck it dry. The wet cake was charged in the saturated brine solution under stirring and ammonia solution (100ml) was added in the reaction mixture at 10- 15C under stirring. The product was extracted in MDC (1000ml) and washed subsequently with dilute acetic acid and water. Aqueous HBr was charged in MDC layer and then MDC was removed atmospherically up-to 50C. Ethanol (700ml) was charged to the residue and raise the temperature of the suspension to 55-60C. The reaction mass was cooled for 1-2 hours at 20-30C and filtered the solid, washed it with Ethanol [100ml x3]. Dried at 55-60C for 12 hours. Yield: 81.3%, 174775-48-5
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Reference£º
Patent; ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur; WO2013/153492; (2013); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem