With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
Into a 500 ml three-necked flask, 36 g (176 mmole) of 4-t-butylphthalic anhydride, 27 g (200 mmole) of t-butylbenzene and 100 ml of dichloroethane were placed under a stream of argon and cooled to 0C. To the obtained mixture, 56 g (420 mmole) of aluminum chloride was slowly added. After the addition was completed, the resultant mixture was stirred at the room temperature for one night. After the reaction was completed, ice was added slowly, and then concentrated hydrochloric acid was added. The formed precipitates were separated by filtration and washed well with water, and 32 g of the benzoic acid compound of the object compound was obtained (the yield: 54%; a white powder)., 32703-79-0
The synthetic route of 32703-79-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IDEMITSU KOSAN CO., LTD.; EP1440959; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem