With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10035-16-2,Benzofuran-5-carbaldehyde,as a common compound, the synthetic route is as follows.
To a solution of aidehyde (400g) in ether (1 Oml) was added LiN (TMS) 2 (1 M in THF, 3. 3ml) at 0C dropwise. The solution was stirred at 0C for 30min and EtMgBr (3M in THF, 1. 83moi) was added dropwise. The reaction was refluxed overnight, cooed to 0C, quenched with saturated ammonium chloride and extracted with ether. The ether was stirred with 3N HCI (20ml), then the aqueous layer was basified with NaOH pellets and extracted with ether. The ether layer was washed with brine, dried with MgS04, filtered and concentrated in vacuo to give 220mg of product (46%)., 10035-16-2
As the paragraph descriping shows that 10035-16-2 is playing an increasingly important role.
Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem