Day: September 3, 2020

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7169-34-8

General procedure: A mixture of 7-substituted 3(2H)-benzofuranones (7a and 7b) (1 eq), substituted aromatic aldehydes (8a-d)(1 eq), in ethanol (10 mL) were added 3 drops of piperidine. The mixture was then heated under reflux for 2 hours. After cooling H2O (20 mL) was added slowly. The crystalline precipitate was separated by filtration and purified by recrystallization from ethanol to afford pure compounds (9a-g).

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Paidakula, Suresh; Nerella, Srinivas; Vadde, Ravinder; Kamal; Kankala, Shravankumar; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2153 – 2156;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,496-41-3

Preparation 10; 2,3-Dihydro-1-benzofuran-2-carboxylic acidA mixture of 1-benzofuran-2-carboxylic acid (40.0 g, 250.0 mmol) and palladium hydroxide (20 wt. % on carbon, 2.0 g) in acetic acid (400 ml) was heated at 60 C. under a hydrogen atmosphere (80 psi) for 2 h. The mixture was filtered to give a solution of the title compound (39.5 g) in acetic acid.1H-NMR (d6-DMSO): 3.19-3.23 (1H), 3.50-3.54 (1H), 5.16-5.20 (1H), 6.78-6.82 (2H), 7.09-7.12 (1H), 7.18-7.20 (1H)

As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; US2008/200540; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24410-59-1, 5-Fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: At -78C, 1.2 mL (1.93 mmol) of a 1.6 M solution of n-butyllithium were slowly added to 175 mg (1.29 mmol) 5-fluorobenzofurane in 10 mL anhydroustetrahydrofurane. The mixture was stirred for 1 h at -78C. 0.52 mL (1.93 mmol) tri-n-buty[tinch[oride was added at -78C. The cooling bath was removed and stirring was continued for 72 h.Methanol was carefully added and the solvent evaporated. The obtained mixture was adsorbed on isolute and purified by flash chromatography. The obtainedmaterial (336 mg) was used directly in the subsequent step 2.Step 2: A mixture of 165 mg of the product from step 1, 100 mg (0.3 mmol) of intermediate 111.1 5, 10.5 mg (0.015 mmol) bis(triphenylphosphine)palladium(II) and 5.7 mg (0.03 mmol) copper(I)iodide in tetrahydrofurane were refluxed for 16 h.The reaction mixture was filtered through a of pad celite. The filtrate wasevaporated and the precipitate was dissolved in tetrahydrofurane. Insolublematerial was filtered off. The filtrate was evaporated and the obtained material was purified by HPLC and preparative thin layer chromatography to give 13 mg of the title compound as solid material., 24410-59-1

The synthetic route of 24410-59-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER INTELLECTUAL PROPERTY GMBH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; WO2013/41634; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

15832-09-4, 6-Methoxy-3(2H)-benzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of benzofuran-3(2H)-one (2.0 mmol), benzaldehyde (2.2mmol) and water (5 mL) was stirred at reflux temperature for 6-10 h. Completion of the reaction was checked on TLC. Then the mixture was allowed to rt and stirred for 1 h. The precipitated solids were filtered, washedwith water (2 ¡Á 5 mL) and dried to give the product., 15832-09-4

The synthetic route of 15832-09-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkateswarlu, Somepalli; Murty, Gandrotu Narasimha; Satyanarayana, Meka; Arkivoc; vol. 2017; 4; (2017); p. 303 – 314;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, Combine the two ammonium salt mixtures from Example 1 (8.86 g, 1 eq), NaBH4 (8.37 g, 5 eq), and tetrahydrofuran (123 ml) into the reaction flask and allow the mixture to cool.A solution of BF3 in tetrahydrofuran (30.77 g, 5 eq) was added dropwise and incubated.After the addition was complete, the mixture was stirred and refluxed overnight. Methanol (30 ml) was added, 100 ml of water was added, and the pH was adjusted by adding hydrochloric acid and heating to 60¡ãC. After cooling, add water 300ml, extract with methyl tert-butyl ether, take the aqueous layer, adjust the pH with NaOH, extract with n-butanol, wash with water,It was evaporated to dryness to afford 6.30 g of a mixture of the compound of formula I-1 and the compound of formula I-2 in a yield of 92percent.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Zhejiang Jiuzhou Pharmaceutical Technology Co., Ltd.; Shen Qirong; Yuan Xiangxiang; Gao Hongjun; Li Yuanqiang; (10 pag.)CN107915672; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A mixture of 3 -fluorophthalic anhydride (1 equiv.), 1 -amino-3 -(4-methoxybenzyl)-3 – azabicyclo[3.1.0]hexane-2,4-dione (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved inDCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2504) and concentrated to provide 4-fluoro adduct.To a solution of the resulting residue (1.0 equiv) in CH3CN, cooled to 0 ¡ãC, is added a solution of CAN (3.0 equiv) in H20, and the yellow clear solution is stirred at 0 ¡ãC for 2 h. Then it is diluted with EtOAc and quenched with half saturated aqueous NaC1 and diluted with EtOAcand H20. The phases are separated, and the aqueous phase is extracted with EtOAc (2 x) and CH2C12 (2 x). The combined organic phases are dried (Na2504), filtered, and concentrated in vacuo. The residue is purified by column chromatography on silica gel to provide 2-(2,4-dioxo-3- azabicyclo[3. 1. 0]hexan- 1 -yl)-4-fluoroisoindoline- 1,3 -dione. (Org. Lett. 2013, 15, 4312)

As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a suspension of magnesium (6.0 equiv) and catalytic amounts of I2 in anhydrous THF (12 mL) was added the appropriate 1-bromoalkane (5.0 equiv) under argon atmosphere until the Grignard reaction had started. After addition was completed, the reaction mixture was refluxed for 2 h and allowed to cool to room temperature. Subsequently, the prepared Grignard solution was added dropwise to a solution of 4 (300 mg, 1.998 mmol) at -5¡ãC. The resulting reaction mixture was stirred at room temperature for 5 h. The mixture was quenched with 3N HCl to pH=2 at 0¡ãC and stirred for another 1 h at room temperature. The solution was extracted with ethyl acetate (15 mL¡Á3). The combined organic layers were washed with 10percent K2CO3 aqueous solution (10 mL¡Á3) and brine (10 mL¡Á2), dried over anhydrous sodium sulfate, and evaporated under reduced pressure. The resulting residue was purified by column chromatography to give intermediates 5a-d as oils., 16859-59-9

The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Qiang, Xiaoming; Li, Yan; Yang, Xia; Luo, Li; Xu, Rui; Zheng, Yunxiaozhu; Cao, Zhongcheng; Tan, Zhenghuai; Deng, Yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 718 – 722;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

90843-31-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

To a stirred solution of 1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one (2.0 g, 13.0 mmol) in dry MeOH (20 mL), NaBH4 (0.68 g, 26.0 mmol, Loba chemie) was added slowly at 0 C. The reaction mixture was stirred at rt for 1 h. It was then concentrated under vacuum and the resulting crude product was dissolved in DCM (50 mL), washed with water, brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was used in the next step without further purification. Yield: 91 % (1.83 g).

As the paragraph descriping shows that 90843-31-5 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 188; l-rfU-Dihydrobenzofuran-l-carbonvD-aminol-indan-l-carboxylic acid acid ethyl ester(188):To a 4OmL vial containing a stirring bar, 2,3-dihydro-l-benzofuran-2-carboxylic acid (0.4g, 2.44mmol) is charged with dry DCM (7mL). Stirring is initiated. HBTU (922mg, 2.43mmol) and the DIPEA (0.95mL, 8.0mmol) are added. The 2-aminoindane-2-carboxylic acid ethyl ester (500mg, 2.44mmol) is added. The reaction is allowed to stir for 16h. Analysis by tic of the reaction mixture (silica, 10% MeOH/DCM) indicates complete consumption of the starting amine. The contents of the reaction flask are diluted with EtOAc (5OmL) and transferred to a separatory funnel. This is washed consecutively with dilute aqueous NaHCO3 (25mL) and brine (25mL), dried over MgSO4, filtered and evaporated in vacuo to provide 1.47g of viscous yellow oil. This material is dissolved in 1OmL of DCM and purified utilizing an ISCO Companion with a 4Og cartridge of silica. The gradient is 15 % EtOAc in heptanes for 3 column volumes followed by a linear gradient to 50% over 8 column volumes and then 90 % EtOAc for 2 column volumes with a ramp of 1 column volume. 25mL fractions are159 collected. Fractions 3 through 6 are combined and evaporated in vacuo. Pumping to a constant weight gives amorphous white solid 0.68g.

1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/151211; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16859-59-9,3-Hydroxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) and DMAP (0.1 equiv) were dis-solved in CH2Cl2 (0.15 M), producing a colorless clear solution. Thedesired carboxylic anhydride (2.0 equiv) and triethylamine (1.0equiv) were subsequently added and the reaction mixture was stirredat r.t. until complete conversion of the starting material was achieved(monitored by TLC). The solvent was removed under reduced pres-sure and the crude products were purified by column chromatogra-phy (n-hexane/EtOAc, 2:1)., 16859-59-9

16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem