24410-59-1, 5-Fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: At -78C, 1.2 mL (1.93 mmol) of a 1.6 M solution of n-butyllithium were slowly added to 175 mg (1.29 mmol) 5-fluorobenzofurane in 10 mL anhydroustetrahydrofurane. The mixture was stirred for 1 h at -78C. 0.52 mL (1.93 mmol) tri-n-buty[tinch[oride was added at -78C. The cooling bath was removed and stirring was continued for 72 h.Methanol was carefully added and the solvent evaporated. The obtained mixture was adsorbed on isolute and purified by flash chromatography. The obtainedmaterial (336 mg) was used directly in the subsequent step 2.Step 2: A mixture of 165 mg of the product from step 1, 100 mg (0.3 mmol) of intermediate 111.1 5, 10.5 mg (0.015 mmol) bis(triphenylphosphine)palladium(II) and 5.7 mg (0.03 mmol) copper(I)iodide in tetrahydrofurane were refluxed for 16 h.The reaction mixture was filtered through a of pad celite. The filtrate wasevaporated and the precipitate was dissolved in tetrahydrofurane. Insolublematerial was filtered off. The filtrate was evaporated and the obtained material was purified by HPLC and preparative thin layer chromatography to give 13 mg of the title compound as solid material., 24410-59-1
The synthetic route of 24410-59-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAYER INTELLECTUAL PROPERTY GMBH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; WO2013/41634; (2013); A1;,
Benzofuran – Wikipedia
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