With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
EXAMPLE 188; l-rfU-Dihydrobenzofuran-l-carbonvD-aminol-indan-l-carboxylic acid acid ethyl ester(188):To a 4OmL vial containing a stirring bar, 2,3-dihydro-l-benzofuran-2-carboxylic acid (0.4g, 2.44mmol) is charged with dry DCM (7mL). Stirring is initiated. HBTU (922mg, 2.43mmol) and the DIPEA (0.95mL, 8.0mmol) are added. The 2-aminoindane-2-carboxylic acid ethyl ester (500mg, 2.44mmol) is added. The reaction is allowed to stir for 16h. Analysis by tic of the reaction mixture (silica, 10% MeOH/DCM) indicates complete consumption of the starting amine. The contents of the reaction flask are diluted with EtOAc (5OmL) and transferred to a separatory funnel. This is washed consecutively with dilute aqueous NaHCO3 (25mL) and brine (25mL), dried over MgSO4, filtered and evaporated in vacuo to provide 1.47g of viscous yellow oil. This material is dissolved in 1OmL of DCM and purified utilizing an ISCO Companion with a 4Og cartridge of silica. The gradient is 15 % EtOAc in heptanes for 3 column volumes followed by a linear gradient to 50% over 8 column volumes and then 90 % EtOAc for 2 column volumes with a ramp of 1 column volume. 25mL fractions are159
1914-60-9, The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.