16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a suspension of magnesium (6.0 equiv) and catalytic amounts of I2 in anhydrous THF (12 mL) was added the appropriate 1-bromoalkane (5.0 equiv) under argon atmosphere until the Grignard reaction had started. After addition was completed, the reaction mixture was refluxed for 2 h and allowed to cool to room temperature. Subsequently, the prepared Grignard solution was added dropwise to a solution of 4 (300 mg, 1.998 mmol) at -5¡ãC. The resulting reaction mixture was stirred at room temperature for 5 h. The mixture was quenched with 3N HCl to pH=2 at 0¡ãC and stirred for another 1 h at room temperature. The solution was extracted with ethyl acetate (15 mL¡Á3). The combined organic layers were washed with 10percent K2CO3 aqueous solution (10 mL¡Á3) and brine (10 mL¡Á2), dried over anhydrous sodium sulfate, and evaporated under reduced pressure. The resulting residue was purified by column chromatography to give intermediates 5a-d as oils., 16859-59-9
The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Qiang, Xiaoming; Li, Yan; Yang, Xia; Luo, Li; Xu, Rui; Zheng, Yunxiaozhu; Cao, Zhongcheng; Tan, Zhenghuai; Deng, Yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 718 – 722;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem