With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.,4265-16-1
To a solution of 2-benzofuran carbaldehyde (1.00 g, 6.85 mmol) in methanol (20 ml) were added hydroxylammonium chloride (530 mg, 7.63 mmol) and pyridine (2.8 ml), followed by stirring at room temperature for 6.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure. Ethyl acetate was added to the resulting residue, followed by washing sequentially with a 5% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogen carbonate solution and then a saturated aqueous sodium chloride solution. The resulting organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to afford the title compound (1.07 g) as a white solid. (Yield: 97%) 1H-NMR spectrum (CDCl3, ppm): 8.47 & 7.81 (brs, total 1H), 8.14 & 7.67 (s, total 1H), 7.69 & 6.96 (d, J=0.9Hz, total 1H), 7.67 & 7.60 (ddd, J=7.7, 1.2, 0.9Hz, total 1H), 7.55-7.49 (m, 1H), 7.43-7.22 (m, 2H).
As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.
Reference£º
Patent; Ube Industries, Ltd.; EP2264009; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem