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High acid crudes contain large amounts of naphthenic acids (NAs), which lead to severe corrosion in oil refinery equipment and serious environmental problems. The goal of this study is to develop a non-catalytic supercritical methanol (scMeOH) route for effective deacidification of NA mixtures and high acid crudes (Laguna and Bachaquero-13). Various reaction parameters, including temperature, pressure, reaction time, and NA-to-methanol ratio, are explored to find effective reaction conditions for reducing the total acid number (TAN) of the mixtures. Almost complete TAN reduction of naphthenic acid (96.9%) is achieved at 400 C, 10 MPa, and 3 h. The reaction in scMeOH at 400 C, 30 MPa and 1 h is effective in the TAN reaction of high acid crudes (93.6-94.0%). The chemical composition of the liquid products obtained under the different reaction conditions, analyzed using gas chromatography-mass spectroscopy, show that esters are the most abundant species, indicating that esterification with scMeOH is the major reaction pathway. The most recalcitrant NA species, which remained after the reaction, are found to be 2-ethyl-2,3,3-trimethyl-butanoic acid and 2,3-dimethyl-2-(1-methylethyl)-butanoic acid. This is attributed to the branched hydrocarbons located near the carboxylic acid groups, which hinder the access of methanol molecules.

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This invention provides novel compounds comprising the following anti-inflammatory pharmacore Formula (I): wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

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Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

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A simple and highly efficient methodology for the first synthesis of isoxazolinyl spiropyrrolidinedione starting from keto ester, is presented. Georg Thieme Verlag Stuttgart – New York.

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A new preparation of trisubstituted imidazopyrazines and dihydroimidazopyrazines via parallel synthesis using aminoacids and bromoketones resulted in the discovery of non-peptidic sst5 selective agonists.

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143878-29-9, Name is Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, belongs to benzofurans compound, is a common compound. COA of Formula: C12H12ClNO4In an article, once mentioned the new application about 143878-29-9.

The invention discloses a process for the alkylation of active methylene compounds. The method comprises the following steps: step A: lively methano-compound will be added to the inorganic alkali -1st polar organic solvent in the mixed system, to be reaction mixture formed; step B:in to be reaction mixture by adding the alkylating agent, the filtrate filtered to get after the reaction, to remove the solvent in the filtrate alkylation chirpy methano-compound obtained. The above-mentioned method, active methylene compounds with inorganic alkali as proton of the reagent composition, not only can ensure in its lively methano-compound alpha-hydrogen getting rid of effects, but also can the vivid methano-compound in the alkylation reaction carried out under relatively mild conditions, to improve the safety of the reaction. At the same time, relatively low price of inorganic base, the alkylation reaction of the production cost is reduced. (by machine translation)

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C12H12ClNO4, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 143878-29-9, name is Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate. In an article,Which mentioned a new discovery about 143878-29-9

Compounds of formula (I): (I) and related aspects.

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Vidal grape grown in Ili, Xinjiang Autonomous Region, is one of few grapes used to ferment ice wine in China. Microbial community structure and volatile composition during the spontaneous fermentation of ice wine made from Vidal grapes in Ili were investigated using amplicon sequencing technology and headspace solid-phase microextraction/gas chromatography-mass spectrometer technologies. Among bacterial genera, Sphingobium, Pseudomonas and Sphingomonas gradually decreased, while Lactobacillus and Streptococcus increased during the spontaneous fermentation process. As regards fungi, the relative abundance of Vishniacozymaand Cladosporium reduced, but Hanseniaspora sharply raised. Additionally, correlations between microbes and volatile compounds were constructed based on multivariate data analysis. The results revealed that the functional core microbiota (mainly composed of eight bacterial genera and nine fungal genera) during ice wine fermentation showed considerable correlations with the formation of twenty-four volatile compounds in ice wine made from Vidal grapes. For example, Saccharomyces was positively correlated with ethanol, ethyl acetate and isoamylol; Hanseniaspora and Candidawere negatively correlated with hexanol; and Lactobacillus and Streptococcus were positively correlated with 2,3-butanediol, ethanol, ethyl acetate, isoamylol and isoamyl acetate. This studyprovides a reference for understanding the process of ice wine fermentation and improving the quality of ice wine made from Vidal grapes.

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Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

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Reaction of 2-ethoxy-2-methyl-1,3-dioxolan (1c) with 1-methoxy-1-trimethylsilyloxyethene (4a) in dichloromethane in the presence of titanium tetrachloride gave 62percent of methyl 2-(2′-methyl-1′,3′-dioxolan-2′-yl)acetate (5a).Similarly, reaction of (1c) with 1-methoxy-1-trimethylsilyloxyprop-1-ene (4b) afforded 73percent of methyl 2-(2′-methyl-1′,3′-dioxolan-2′-yl)propanoate (5b).

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