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Radical cleavage of the carbon-cobalt bond of 2-acetyl-2-methoxy-carbonylpropyl cobaloxime (1) and 2-benzoyl-2-phenylpropyl cobaloxime (5) gives the enones wich are formed by the 1,2-migration of acyl-group.

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Benzofuran – Wikipedia,
Benzofuran | C8H4093O – PubChem

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Organozinc intermediates (Reformatsky reagents) derived from alpha-bromocarboxylic acid esters react with acyl chlorides in the presence of dioxane to afford both C- and O-acylation products, 3-oxoalkanoic (3-acyloxy-2-alkenoic) acid esters and 1-acyloxy-1-alkoxyalkenes. The latter are formed as the only reaction products when the organozinc intermediate contains an alkyl group at the nucleophilic C2 center and when the acyl chloride possesses a bulky radical on the carbonyl group.

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Benzofuran – Wikipedia,
Benzofuran | C8H4081O – PubChem

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Deprotonation of methyl acetoacetate yields two enolate ions MeCOC-HCO2Me (a) and C-H2COCH2CO2Me (b).On collisional activation, ions a and b fragment differently.The major fragmentation of a is specific loss of MeOH through a four-centered transition state to form -O(Me)C=C=C=O.In contrast, ion b eliminates CH2CO to give -CH2CO2Me.Some rearrangement of b to a is also noted.Rearrangemnent of a to b is very minor under single collision conditions but at high collosion gas pressure rearrangement of a to b is strongly promoted.Similar effects are observed in the collosional activation spectra of MeCOC-(Me)CO2Me (c) and -CH2COC(Me)CO2Me (d).The loss of MeOH from (c) proceeds via a six membered transition state to -CH2-CO-C(Me)=C=O; this is a stepwise process in which the deprotonation (step two) in not rate detrermining.A number of other decompositions occur, these have also been studied by deuterium labelling.

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Benzofuran – Wikipedia,
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Recyclable and reusable mesoporous silica anchored Ru catalysts based on 4,4?-substituted BINAPs were synthesized and used for the hydrogenation of beta-alkyl beta-ketoesters with up to 98.6% e.e. and beta-aryl beta-ketoesters with up to 95.2% e.e.

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Functionalization of methyl isobutyrate can be performed through its enolate condensation with N,N’-carbonyldiimidazole and several of its derivatives.

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Benzofuran – Wikipedia,
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Face off: The ruthenium complexes of a new axially chiral PNNligand (L) are highly efficient in the presence of dimethylsulfoxide (DMSO) for hydrogenation of both functionalized and unfunctionalized tert-alkyl ketones. DMSO is thought to narrow down the many possible complex stereoisomers into a single facial L/Ru complex, thus enhancing the reactivity, selectivity, and productivity. Copyright

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Benzofuran – Wikipedia,
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The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

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Benzofuran – Wikipedia,
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The acylation of unsymmetrical ketones to beta-ketoesters at a tertiary enolate center can be selectively achieved by way of the stable beta-dithioketoesters (eq. 2).These undergo one-step or sequential conversion to the beta-ketoesters using HgO-BF3.

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Benzofuran – Wikipedia,
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Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.

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Benzofuran – Wikipedia,
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We describe a complete account of our total synthesis and biological evaluation of (?)-berkelic acid and analogs. We delineate a synthetic strategy inspired by a potentially biomimetic union between the natural products spicifernin and pulvilloric acid. After defining optimal parameters, we executed a one-pot silver-mediated in situ dehydration of an isochroman lactol to methyl pulvillorate, the cycloisomerization of a spicifernin-like alkynol to the corresponding exocyclic enol ether, and a subsequent cycloaddition to deliver the tetracyclic core of berkelic acid. Our studies confirm that the original assigned berkelic acid structure is not stable and equilibrates into a mixture of 4 diastereomers, fully characterized by X-ray crystallography. In addition to berkelic acid, C22-epi-berkelic acid, and nor-berkelic acids, we synthesized C26-oxoberkelic acid analogs that were evaluated against human cancer cell lines. In contrast to data reported for natural berkelic acid, our synthetic material and analogs were found to be devoid of activity.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H4074O – PubChem