One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 143878-29-9, Name is Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, molecular formula is C12H12ClNO4
Deprotonation of methyl acetoacetate yields two enolate ions MeCOC-HCO2Me (a) and C-H2COCH2CO2Me (b).On collisional activation, ions a and b fragment differently.The major fragmentation of a is specific loss of MeOH through a four-centered transition state to form -O(Me)C=C=C=O.In contrast, ion b eliminates CH2CO to give -CH2CO2Me.Some rearrangement of b to a is also noted.Rearrangemnent of a to b is very minor under single collision conditions but at high collosion gas pressure rearrangement of a to b is strongly promoted.Similar effects are observed in the collosional activation spectra of MeCOC-(Me)CO2Me (c) and -CH2COC(Me)CO2Me (d).The loss of MeOH from (c) proceeds via a six membered transition state to -CH2-CO-C(Me)=C=O; this is a stepwise process in which the deprotonation (step two) in not rate detrermining.A number of other decompositions occur, these have also been studied by deuterium labelling.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 143878-29-9
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4080O – PubChem