One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 143878-29-9, Name is Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, molecular formula is C12H12ClNO4
We describe a complete account of our total synthesis and biological evaluation of (?)-berkelic acid and analogs. We delineate a synthetic strategy inspired by a potentially biomimetic union between the natural products spicifernin and pulvilloric acid. After defining optimal parameters, we executed a one-pot silver-mediated in situ dehydration of an isochroman lactol to methyl pulvillorate, the cycloisomerization of a spicifernin-like alkynol to the corresponding exocyclic enol ether, and a subsequent cycloaddition to deliver the tetracyclic core of berkelic acid. Our studies confirm that the original assigned berkelic acid structure is not stable and equilibrates into a mixture of 4 diastereomers, fully characterized by X-ray crystallography. In addition to berkelic acid, C22-epi-berkelic acid, and nor-berkelic acids, we synthesized C26-oxoberkelic acid analogs that were evaluated against human cancer cell lines. In contrast to data reported for natural berkelic acid, our synthetic material and analogs were found to be devoid of activity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 143878-29-9, in my other articles.
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4074O – PubChem