With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.
Compound 4 (5-bromobenzofuran, 8.5 g, 43.4 mmol),Compound 5 (4-(methoxycarbonyl)phenylboronic acid,8.6 g, 47.8 mmol) dissolved in MeOH (9.0 mL, 1 mL/g),In toluene (90.0 mL, 10 mL/g),Add Cs2CO3 (28.1g, 86.3mmol),Then fill with nitrogen. Pd(PPh3)4 (2.5 g, 2.2 mmol) was added under nitrogen,It was then stirred under reflux for 2 hours. After the reaction,The reaction was filtered through celite and concentrated.Then, by recrystallization, a white solid compound 6 (9.7 g, yield: 89percent) was obtained.
23145-07-5, 23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Dongjin Shimeiken Co., Ltd.; Cui Zhenyu; Jiang Bingnan; Yin Xingyi; Song Zhenyin; Jin Xingxie; Li Dongxuan; Cui Zhien; Li Xuanzhi; Shen Guichun; (45 pag.)CN109206387; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem