143878-29-9, Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The resulting intermediate 7 (30 g, 0.11 mol), water (150 mL),Propylene glycol monomethyl ether (36mL) and 50% sodium hydroxide solution (90mL), slowly heated to 90 C with stirring, the same temperature for 8h, the reaction was monitored by TLC. After the reaction is completed,Cooled to 5 C with ice bath and stirred for 2h, filtered with suction,The filter cake was washed with an appropriate amount of water added to 500mL single-necked flask,Water (210 mL) and propylene glycol monomethyl ether (35 mL) were added,The temperature of the reaction solution was raised to 80 C and the reaction solution became homogeneous.Dilute dilute hydrochloric acid, adjust pH to about 3, precipitated solid.After cooling to 10 C, stirring was continued for 2h. Suction filtration,The filter cake was washed with an appropriate amount of water and dried to give an off-white solid,Yield 20.8g, yield 89.8%, purity 99%, 143878-29-9
The synthetic route of 143878-29-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shenyang Pharmaceutical University; Wang Shaojie; Lei Yu; Bao Li; (9 pag.)CN107337658; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem