With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
General procedure: A reaction vessel was charged with phthalic anhydride (1.0 mmol), alkyl acrylate (2.0 mmol), ruthenium catalyst (0.015 mmol, 9mg), Cu(OAc)2*H2O (400 mg, 2.0 mmol), and NMP (3ml) in air. The reaction vessel was then sealed and stirred at 120 C for 20 h. Then, the mixture was cooled to room temperature and diluted with ethyl acetate and washed with brine. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. The resulting residue that was purified by column chromatography using ethyl acetate-hexane (15:85) as the solvent, and then recrystallized in ethyl acetate-hexane (15:85).
32703-79-0, As the paragraph descriping shows that 32703-79-0 is playing an increasingly important role.
Reference£º
Article; Kianmehr, Ebrahim; Fardpour, Maryam; Darvish, Ali; Kharat, Ali Nemati; Weng Ng, Seik; Tetrahedron Letters; vol. 60; 10; (2019); p. 699 – 702;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem