Downstream synthetic route of 21535-97-7

21535-97-7, 3-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Methylbenzofuran 3 (5.08 g, 38.5 mmol) is treated with SeO2 (5.10 g, 46.2 mmol) in accordance with Method D affording the title compound (3.08 g) after column chromatography (silica gel, 5% EtOAc in heptanes) as a light yellow wax: 1H NMR (360 MHz, CDCl3, deltaH) 10.19 (IH, s), 8.28 (IH, s), 8.20 (IH, dd), 7.57 (IH, dd), 7.43 (IH, app td), 7.40 (IH, app td).; Method D[00102] In accordance with the procedure of Zaidlewicz et al. (Heterocycles, 2001, 55,569-577), a suspension of the 3-methylbenzofuran (1 equiv) and SeO2 (1.2 equiv) in 1,4- dioxane (6 vol) is warmed to reflux and stirred 24 h. At this juncture, reaction progress is assessed by TLC or LC/MS. If the reaction is incomplete, a further portion of SeO2 (1.2 equiv) is added and stirring continued at reflux for a further 24 h. On completion the reaction mixture is allowed to cool to rt and filtered through Celite 521. The filter cake is washed with EtOAc (12 vol), the filtrate coned in vacuo, and the residue purified by column chromatography (silica gel, 5-40% EtOAc in heptanes) affording the desired product., 21535-97-7

21535-97-7 3-Methylbenzofuran 88939, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; WO2009/85256; (2009); A1;,
Benzofuran – Wikipedia
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