Day: November 10, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

General procedure: Classical heating procedure A: 1g of Al2O3-KF was added to the benzofuranone derivative (0.6 mmol) and the aldehyde (1.0-1.5 eq) dissolved in acetonitrile (1-2 mL). The mixture was evaporated under vacuum and the resulting solid was heated at 70 C until TLC showed disappearance of the starting material (3-8 h). The mixture was extracted with ethanol and Al2O3-KF was removed by filtration. The filtrate was evaporated under reduced pressure to afford the corresponding crude aurone., 15832-09-4

As the paragraph descriping shows that 15832-09-4 is playing an increasingly important role.

Reference£º
Article; Boussafi, Karima; Villemin, Didier; Bar, Nathalie; Belghosi, Mabrouk; Journal of Chemical Research; vol. 40; 9; (2016); p. 567 – 569;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-(2-Furyl)-5,5-dimethyl-4-oxo-4,5-dihydro-3-furancarbonitrile (3a). To a stirred solutionoffuran-2-carboxylic acid (1a) (112 mg,1 mmol) and 4-hydroxy-4-methyl-2-pentynenitrile (2a) (135 mg,1.2 mmol) in MeCN (5 mL), Et3N (101 mg,1 mmol) was added dropwise over 1 min. The reaction mixture was irradiated with microwave at 100 C at 1.2 atm for 2 h (or was stirred at 100 C for 5 h). The residue was concentrated and washed with a mixture of C5H12-(CH3)2CO, 5:1 and 3:1, and then recrystallized with (CH3)2CO to give the desired product 3a as colorless crystals (172 mg, 85% or163 mg, 80% at 100C);

496-41-3, The synthetic route of 496-41-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Trofimov, Boris A.; Stepanov, Anton V.; Malkina, Anastasiya G.; Volostnykh, Olga G.; Shemyakina, Olesya A.; Ushakov, Igor A.; Synthetic Communications; vol. 45; 23; (2015); p. 2718 – 2729;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

16859-59-9, General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) and DMAP (0.1 equiv) were dis-solved in CH2Cl2 (0.15 M), producing a colorless clear solution. Thedesired carboxylic anhydride (2.0 equiv) and triethylamine (1.0equiv) were subsequently added and the reaction mixture was stirredat r.t. until complete conversion of the starting material was achieved(monitored by TLC). The solvent was removed under reduced pres-sure and the crude products were purified by column chromatogra-phy (n-hexane/EtOAc, 2:1).

The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196799-45-8,2,3-Dihydrobenzofuran-7-carbaldehyde,as a common compound, the synthetic route is as follows.

(4′-(Pyridin-2-yl)tetrahydrospiro[bicyclo[3.1.0]hexane-3,2′-pyran]-4′-yl)ethylamine (68E) (0.22 g, 0.808 mmol) dissolved in dichloromethane (10 mL)In the middle, sodium sulfate (0.57g, 4.04mmol)And 2,3-dihydrobenzofuran-7-carbaldehyde (0.144 g, 0.97 mmol) was added to the reaction.The reaction was carried out overnight at room temperature. Sodium borohydride(0.046 g, 1.10 mmol) was added to the reaction, and the reaction was stirred for 10 minutes.Further methanol (10 mL) was added and the reaction was stirred for 1 hour.The reaction was quenched with water and aqueous was extracted with dichloromethane (20mL¡Á3).The combined organic phases were washed with a saturated sodium chloride solution (30 mL).Dry with anhydrous sodium sulfate, filter, and concentrate the filtrate.Column chromatography on crude product (dichloromethane/methanol (v/v) = 50:1 to 20:1)Obtaining a yellow oily liquidN-((2,3-dihydrobenzofuran-7-yl)methyl)-2-(4′-(pyridin-2-yl)tetrahydrospiro[bicyclo[3.1.0]hexane-3, 2′-pyran]-4′-yl)ethylamine (76B) (0.22 g, yield: 67.5%)., 196799-45-8

The synthetic route of 196799-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

In the glove box,Cs2CO3 (0.6 mmol) and benzofuran-2-carbaldehyde (0.2 mmol) were weighed into 25 mL of the reaction tube,Measure the amount of DMA (1 mL) into the reaction tube.A bromodifluoromethylphosphonium salt (0.6 mmol) was weighed,Treated with DMA (2 mL)Inhalation into the syringe.Stirred at room temperature,A DMA solution of bromodifluoromethylphosphonium salt was injected into the reaction tube at a rate of 0.5 mL / h with a syringe pump.After the injection, the reaction is over. The solution in the reaction tube was transferred to a separatory funnel, 15 mL of water was added, extracted three times with dichloromethane (10 mL x 3), and the organic phases were combined and washed three times with water (10 mL x 3). The final obtained organic phase was dried over anhydrous sodium sulfate, and the solid was filtered off, the solvent removed by rotary evaporation, on a silica gel column with n-pentane and ethyl acetate as eluent, to give the final isolated product difluoromethyl, yield 72%, purity> 99.9%., 4265-16-1

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

Reference£º
Patent; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences; Xiao, Jichang; Deng, Zuyong; Lin, Jinhong; (37 pag.)CN106146556; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dibenzofuran-1,3-diol (prepared according to Carvalho, C. F. et al. (Supra)) (200 mg, 1 mmol), 2-fluoronaphthalene-1,3-diol 34 (178 mg, 1 mmol, AB part number 361828) and anhydrous 2,5-dichlorotrimellitic acid (260 mg, 1 mmol, AB part number 361892) were mixed in methanesulfonic acid (10 mL). Then, the mixture was stirred at 130 to 135 C. for 2 hours. The reaction mixture was cooled and mixed with ice water (100 mL). The precipitated dye was extracted with ethyl acetate (100 mL). The organic layer was washed with water (50 mL ¡Á 2) and washed with brine (50 mL ¡Á 1). After drying over sodium sulfate, the mixture was filtered, the solvent was removed, and the crude pigment was obtained as an isomeric mixture. These isomers were separated by thin layer chromatographic separation and 80 mg (13%) of a dye was obtained., 81742-10-1

As the paragraph descriping shows that 81742-10-1 is playing an increasingly important role.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7168-85-6, 7-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7168-85-6

A mixture of 500 mg (3.38 mmol) 7-methoxy-1 -benzofuran in anhydrous THF (30 mL) was cooled to -78 C. 3.2 mL (5 mmol) of a 1.6 M solution of n-butyllithium in hexane was added and the resulting mixture stirred for 1 h at -78C. 1.37 mL (5 mmol) of tributyltin chloride was added. The reaction was stirred at rt over night. Methanol was carefully added and the solvent evaporated. The obtained residue was purified by flash chromatography to yield 1.3 g of crude product of the corresponding 2-stannylbenzofurane, which was used without further purification.

7168-85-6 7-Methoxybenzofuran 590462, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Intellectual Property GmbH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; HITCHCOCK, Marion; WO2013/34570; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

General procedure: Amine (1.05 Equiv) was added to Isatoic anhydride (1.0 Equiv) in water (4.0mL) and PEG400 (1.0mL) at RT and stirred for 1-2 hr. Upon completion of SM by TLC, added 3-bromoisobenzofuran-1(3H)-one (1.1 Equiv) and warm the reaction mixture to 90-95 C and maintained for 10-14 h. After completion of the reaction, cool the reaction mass up to 25-30 C and product was filtered and further purified via column chromatography through silica gel stationary phase and Ethyl acetate & Heptane mixture as eluent., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Madhubabu; Shankar; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh; Tetrahedron Letters; vol. 57; 46; (2016); p. 5033 – 5037;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

58546-89-7, Benzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,58546-89-7

PREPARATION VIII N-(4-fluorobenzoyl)-5-aminobenzofuran The title compound is obtained from 4-fluorobenzoyl chloride and 5-aminobenzofuran by the procedure of Preparation VI.

58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; EP875513; (1998); A1;; ; Patent; Eli Lilly and Company; US5874427; (1999); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64169-34-2,5-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

5-Bromophthalide (50g, 235 mmol), potassium vinyl trifluoroborate (62.9 g, 469 mmol), and PdCl2(dppf)-CH2Cl2 Adduct (9.58 g, 11.7 mmol) were added to ethanol (500 mL) then TEA (65.4 mL, 469 mmol) was added. The reaction mixture was degassed then heated at reflux for 8 h. The reaction was worked up by diluting with ethyl acetate and washing with brine twice. The organic layer was dried and evaporated to dryness. The crude product was purified by MPLC (silica, 600g column) with 25% EtOAc/hexane (3 L) then with 30% EtOAc/Hexane (2 L) to yield the title compound., 64169-34-2

As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PIO, Barbara; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; WALSH, Shawn; WO2013/90271; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem