Analyzing the synthesis route of 196799-45-8

The synthetic route of 196799-45-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196799-45-8,2,3-Dihydrobenzofuran-7-carbaldehyde,as a common compound, the synthetic route is as follows.

(4′-(Pyridin-2-yl)tetrahydrospiro[bicyclo[3.1.0]hexane-3,2′-pyran]-4′-yl)ethylamine (68E) (0.22 g, 0.808 mmol) dissolved in dichloromethane (10 mL)In the middle, sodium sulfate (0.57g, 4.04mmol)And 2,3-dihydrobenzofuran-7-carbaldehyde (0.144 g, 0.97 mmol) was added to the reaction.The reaction was carried out overnight at room temperature. Sodium borohydride(0.046 g, 1.10 mmol) was added to the reaction, and the reaction was stirred for 10 minutes.Further methanol (10 mL) was added and the reaction was stirred for 1 hour.The reaction was quenched with water and aqueous was extracted with dichloromethane (20mL¡Á3).The combined organic phases were washed with a saturated sodium chloride solution (30 mL).Dry with anhydrous sodium sulfate, filter, and concentrate the filtrate.Column chromatography on crude product (dichloromethane/methanol (v/v) = 50:1 to 20:1)Obtaining a yellow oily liquidN-((2,3-dihydrobenzofuran-7-yl)methyl)-2-(4′-(pyridin-2-yl)tetrahydrospiro[bicyclo[3.1.0]hexane-3, 2′-pyran]-4′-yl)ethylamine (76B) (0.22 g, yield: 67.5%)., 196799-45-8

The synthetic route of 196799-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem