Day: November 17, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13391-28-1,5-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

Step 5: BBr3 (2.6 mL, 13.5 mmol) was added dropwise to S22-4 (2.0 g, 13.Smmol) in DCM (20mL) at -60 C under N2. The solution was stirred at 0C for 2h. The mixture was poured into iceand adjusted the pH to 1213. The inorganic phase was extracted with DCM. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtrated and concentrated to provide a residue, which was purified by column chromatography to afford S22-5.

13391-28-1, The synthetic route of 13391-28-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIANG, Gui-Bai; ZHOU, Changyou; WANG, Haisheng; HUO, Xianghong; WO2015/95261; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206347-30-0,7-Bromo-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

[1289] A first intermediate compound 4-(2,3-Dihydro-benzofuran-7-yl)-piperazine-1-carboxylic acid tert-butyl ester, was produced as follows: A solution of bis-(dibenzylideneacetone)palladium(0) (4.92 g, 0.16 mol) and toluene (2500 ml) was degassed with nitrogen for 15 minutes. (Note: Degassing was continued during each addition. Time between additions was 15 minutes.) Then added was tri-o-tolylphosphine (4.92 g, 0.16 mol) then sodium t-butoxide (53.8 g, 0.56 mol) then Boc-piperazine (86.8 g, 0.47 mol) then a solution of 7-bromo-2,3-dihydro-benzofuran (79.6 g, 0.40 mol, prepared according to Tetrahedron Lett. 1998, 39, 2219) in toluene (100 ml). The reaction mixture was stirred at reflux for 16 h. By TLC, all starting material had been consumed. The cooled reaction mixture was filtered over a pad of Celite. The filtrate was concentrated under reduced pressure and the residue was triturated with ethyl acetate in heptane (50%). The insoluble material was filtered off and that filtrate was concentrated under reduced pressure. The crude residue was purified by flash column chromatography using ethyl acetate in heptane (50%) to give 46.4 g (38% yield) of the first intermediate compound as a tan solid., 206347-30-0

As the paragraph descriping shows that 206347-30-0 is playing an increasingly important role.

Reference£º
Patent; Clark, Jerry D.; Davis, Jamie M.; Favor, David; Fay, Lorraine K.; Franklin, Lloyd; Henegar, Kevin E.; Johnson, Douglas S.; Nichelson, Brian J.; Ou, Ligong; Repine, Joseph Thomas; Walters, Michael A.; White, Andrew David; Zhu, Zhijian; US2005/43309; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.,7169-34-8

General procedure: To a solution of benzofuran-3(2H)-one derivative (2a,b,d, 1.2 mmol) in ethanol (5 ml) in the presence of corresponding benzaldehyde (1.3 mmol), aqueous solution of 5% HCl (1 ml) was added and the mixture was refluxed for 6-9 hours (controlled by TLC). After cooling in an ice bath, the solution was neutralized by adding a cold solution of 2% KOH to reach the pH of 5-6. The resulting yellow precipitate was filtered and recrystallized from diluted methanol to give the desired products.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Roshanzamir, Khashayar; Kashani-Amin, Elaheh; Ebrahim-Habibi, Azadeh; Navidpour, Latifeh; Letters in drug design and discovery; vol. 16; 3; (2019); p. 333 – 340;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57319-65-0

Example 16 3-(6-Amino-3H-isobenzofuran-1-ylidene)-5-chloro-1,3-dihydro-indol-2-one To a solution of 5-chlorooxindole (0.629 g, 3.78 mmol) in 10.0 mL monoglyme was added 7.51 mL sodium hexamethyldisilazane (1.0 M in THF) over 3 min. After stirring at room temperature for 8 min, a slurry of 6-aminophthalide (0.561 g, 3.78 mmol) in 4.0 mL of monoglyme was added in one portion. The mixture was stirred for 40 min and then quenched into 100 mL of 4% aqueous HCl solution. The yellow solid was filtered and then partitioned between EtOAc and saturated NaHCO3 (heated to dissolve the solid). The organic phase was washed with H2O, brine and then dried with Na2SO4. The solvent was removed in vacuo and the residue was triturated with MeOH to give the title compound (439 mg, 39%) as a yellow solid.

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan Sales, LLC; US6541504; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

52010-22-7, 4-Chlorophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52010-22-7

(a) 3-bromo-4-chloroisobenzofuran-1(3H)-one (100) 4-chloroisobenzofuran-1(3H)-one (10 g, 59.32 mmol), (E)-2,2′-(diazene-1,2-diyl)bis(2-methylpropanenitrile) (0.974 g, 5.93 mmol) and 1-bromopyrrolidine-2,5-dione (11.61 g, 65.25 mmol) were dissolved CCl4 (100 mL) and heated at reflux for 2 hours. The reaction was cooled and filtered, the filtrate was evaporated to the desired compound as a yellow gum (14.20 g, 97% yield); 1H NMR (400.132 MHz, CDCl3) delta 7.32 (1H, s), 7.61 (1H, t), 7.73 (1H, d), 7.88 (1H, d); m/z (LC-MS, ESI+), RT=2.28 (M+H not detected).

52010-22-7 4-Chlorophthalide 3040300, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; MENEAR, Keith Allan; Javaid, Muhammad Hashim; Gomez, Sylvie; Hummersone, Marc Geoffrey; Lence, Carlos Fenandez; Martin, Niall Morrison Barr; Rudge, David Alan; Roberts, Craig Anthony; Blades, Kevin; US2009/192156; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

569-31-3,569-31-3, 6,7-Dimethoxy-3H-1-isobenzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.

As the paragraph descriping shows that 569-31-3 is playing an increasingly important role.

Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

69604-00-8,69604-00-8, Ethyl 5-nitrobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Commercially available ethyl 5-NITROBENZOFURAN-2-CARBOXYLATE 30 was HYDROGENATED on PD-C and ACYLATED using commercially available 4-NITRO-N-METHYL-2- TRICHLOROACETYL-PYRROLE 32 to form 33. HYDROGENATION of 33 followed by acylation with 32 afforded the nitro compound 35, which upon HYDROGENATION yielded 36 as the amino compound. ACETYLATION of the amino group of 36 followed by base catalyzed hydrolysis resulted in the acid 37. Coupling of 37 with the hydrochloride salt 39 (obtained by DEPROTECTION of the BOC derivative 38) using EDC afforded the ester 40. See Figure 4.

69604-00-8 Ethyl 5-nitrobenzofuran-2-carboxylate 1382954, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2005/32594; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-06-3,4,5-Dichlorophthalic Anhydride,as a common compound, the synthetic route is as follows.

4,5-Dichlorophthalic anhydride (430 mg, 2.0 mmol) and 4-aminobutyric acid (206 mg, 2.0 mmol) were added to glacial acetic acid (10 mL) and heated to 100 C for 3 h. The reaction was quenched with water (10 mL) and the NaOH solution (0.1 mol/L) was adjusted to pH 6-8. Dichloromethane extraction (10mL ¡Á 3), washed with saturated NaHCO3 solution, washed with water, combined with organic phase, dried over anhydrous sodium sulfateDry and dry, 576mg of yellow solid.LC-MS and 1H-NMR confirmed the expected intermediate compound in a yield of 96.0%., 942-06-3

The synthetic route of 942-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Chinese Academy Of Sciences Animal Institute; Wu Song; Zhou Qi; Zhang Wenxuan; Wu Jun; Wu Hongna; Hao Jie; Wang Liu; (88 pag.)CN109867661; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of benzofuran-3(2H)-one (134mg, 1mmol) in dry methanol (20mL) at room temperature was added the appropriate aldehyde (1.2mmol) and Al2O3 (1mmol). The mixture was refluxed, under N2, for 48h. After, the solvent was removed and the solid residue was dissolved in CH2Cl2. The organic layer was washed with water, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product.

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 523 – 534;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

Method B To an ice-cooled solution of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (15a) (0.33 g, 2.0 mmol) in 3 ml of acetic acid there was added dropwise 0.6 ml of HNO3. The mixture was stirred in a warm oil bath (70C) for 24 hours, and then poured into water. After cooling, the product was collected on a filter to give 0.21 g of solid (50.2%). This was recrystallized from ethyl acetate to afford 0.14 g (33.5%) of 15k , mp 249-251.5C., 35700-40-4

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Erbamont Inc.; EP234872; (1991); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem