Day: November 24, 2020

4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzofuran-3-carbaldehyde (5 g, 33.8 mmol) in methanol (50 mL) was cooled with ice and sodium borohydride (1.9 g, 50.7 mmol) was added portionwise. The reaction mixture was stirred at rt for 1 h. The mixture was concentrated and the residue was partitioned between saturated ammonium chloride and DCM. The organic layer was separated, dried over sodium sulfate and concentrated. The crude benzofuran-3-ylmethanol (4.6 g, 92%) was taken as such for next step without further purification.

4687-25-6, As the paragraph descriping shows that 4687-25-6 is playing an increasingly important role.

Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (302 pag.)WO2019/99582; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

209256-42-8, 2,3-Dihydrobenzofuran-4-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1050 mL (1.05 mol) of a 1.0 M solution of vinyl magnesium bromide in tetrahydrofuran was added to the reaction flask, the stirring was started, the reaction solution was cooled to -10 to -5 C, and 2,3-dihydrobenzofuran-4 was added dropwise. -A solution of formaldehyde (148.2 g, 1.00 mol) in tetrahydrofuran (500 mL), and the temperature of the reaction solution is controlled to not exceed -5 C. After the completion of the dropwise addition, the reaction was maintained at a temperature of -10 to -5 C for half an hour, and then slowly warmed to room temperature to continue the reaction. After 6 hours, 300 mL of a saturated ammonium chloride aqueous solution was added, and after stirring for 30 minutes, extraction was performed with ethyl acetate three times (800 mL ¡Á 3). The organic phase was washed once with a saturated sodium chloride solution (300 mL) and water (300 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to dryness under reduced pressure to obtain 173.6 g of a yellow oil with a yield of 98.5%., 209256-42-8

The synthetic route of 209256-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Changzhou Yabang Pharmaceutical Co., Ltd.; Chen Zaixin; Ji Xiaolong; Xia Zhengjun; Zang Lujie; Xia Lingxian; Hao Jinxing; Wang Fan; (12 pag.)CN104926763; (2019); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-16-1,4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-chlorobenzofuran-2-carboxylic acid (0.274 g, 1.4 mmol, 1.5 equiv) in DMF (10 mL) was added DIPEA (0.5 mL, 2.7 mmol, 3.0 equiv) followed by the addition of HATU (0.706 g, 1.8 mmol, 2.0 equiv) and the resultant reaction mixture was stirred for 30 min. Trans-tert-butyl (4-aminocyclohexyl)carbamate (0.200 g, 0.90 mmol, 1.0 equiv) was added and the reaction mixture was allowed to stir overnight at RT and the resulting precipitate was filtered off and washed with excess methanol to obtain trans-tert-butyl (4-(5-chlorobenzofuran-2-carboxamido)cyclohexyl)carbamate (350 mg, 64% Yield) as an off-white solid. LCMS: 393 [M+H]+., 10242-10-1

10242-10-1 5-Chlorobenzofuran-2-carboxylic acid 937838, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Praxis Biotech LLC; BERNALES, Sebastian; DELGADO OYARZO, Luz Marina; NUNEZ VASQUEZ, Gonzalo Esteban; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BHATT, Bhawana; CHAKRAVARTY, Sarvajit; US2019/177310; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

35700-40-4, 2,3-Dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 2,3-dihydro-l-benzofuran-7-ylmethanol [00878] Added BH3 (1M in THF, 9 mL) to a solution of 2,3-dihydro-l-benzofuran-7- carboxylic acid (481 mg, 2.93 mmol) in THF (7 mL) drop wise at 0C, thereto, the mixture was stirred at room temperature overnight. Extracted with ethyl acetate twice, and washed the organic phase with brine and dried with anhydrous Na2S04, concentrated to give the title compound (340 mg, 77%). 1H NMR (400 MHz, CDC13): delta 2.09 (1H, s), 3.22 (2H, t, J= 8.8 Hz), 4.61 (2H, t, J= 8.8 Hz), 4.67 (2H, s), 6.83 (1H, t, J= 7.6 Hz), 7.08 (1H, d, J= 7.2 Hz), 7.14 (1H, d, J= 7.2 Hz)., 35700-40-4

The synthetic route of 35700-40-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; QUANTICEL PHARMACEUTICALS, INC; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/89364; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

57319-65-0, Phthalide 29. To a stirred solution of 6-aminophthalide (10.0 g, 67.0 mmol, 1.0 equiv), DMAP (164 mg, 1.34 mmol, 0.02 equiv), and Et3N (13.6 g, 18.7 mL, 134 mmol, 2.0 equiv) in THF (40 mL) at 0 C, Boc20 (17.6 g, 80.4 mmol, 1.2 equiv) was added portionwise over 10 min under vigorous stirring at 0 C (CA UTION: gas evolution). Upon completion of addition, the ice bath was removed and the reaction mixture was stirred for 3 h at 40 C and was diluted with EtOAc (50 mL), cooled to 0 C, quenched by careful addition of saturated aq. NH4CI (40 mL). The resulting mixture was extracted with EtOAc (3 x 50 mL), and the combined organic layers were washed with water (50 mL) and brine (50 mL), dried over MgSC>4 and concentrated. Flash column chromatography (silica gel, hexanes:EtOAc 2: 1 to 1 : 1) gave phthalide 29 as a yellowish solid (13.4 g, 53.6 mmol, 80% yield). 29: R/ = 0.31 (silica gel, hexanes:EtOAc 2: 1); IR (film) vmax = 3341, 2979, 2931, 2851, 1741, 1719, 1604, 1538, 1497, 1450, 1423, 1390, 1365, 1316, 1299, 1234, 1126, 1063, 1002 cm”1; FontWeight=”Bold” FontSize=”10″ H NMR (500 MHz, CDC13): delta = 7.83 (d, J = 2.0, 1 H), 7.76 (d, J = 7.8, 1 H), 7.36 (d, J = 8.3, 1 H), 6.92 (br, 1 H), 5.23 (s, 2 H), 1.47 (s, 9 H) ppm; 1 C NMR (125 MHz, CDC13): delta = 170.9, 152.5, 140.5, 139.6, 126.4, 124.8, 122.5, 114.6, 81.1, 69.5, 28.2 ppm; HRMS (ESI-TOF): calcd for Ci3H16N04+ [M+H+]: 250.1074, found 250.1076.

57319-65-0 6-Aminoisobenzofuran-1(3H)-one 93631, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; WILLIAM MARSH RICE UNIVERSITY; BRISTOL-MYERS SQUIBB COMPANY; THE SCRIPPS RESEARCH INSTITUTE; NICOLAOU, Kyriacos, C.; LU, Min; MANDAL, Debashis; GANGWAR, Sanjeev; CHOWDARI, Naidu, S.; POUDEL, Yam, B.; WO2015/23879; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: 1-Boc-piperazine (150 mg, 0.81 mmoles) was dissolved in anhydrous DMF (2 mL) and, under stirring, DIPEA (303 mL, 1.78 mmoles), PyBOP (461 mg, 0.89 mmoles) and 2-thiophenecarboxylic acid (114 mg, 0.89 mmoles) were added at room temperature. After complete conversion of 1-Boc-piperazine monitored by TLC analysis, the solution was diluted with DCM and washed with NaOH 0.5M, brine, HCl 0.1M and brine. Organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by chromatographic column (eluent DCM/MeOH = 96/4) to obtain 10e (188 mg, 79% yield).

24673-56-1, As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Article; Giannini, Giuseppe; Battistuzzi, Gianfranco; Vesci, Loredana; Milazzo, Ferdinando M.; De Paolis, Francesca; Barbarino, Marcella; Guglielmi, Mario Berardino; Carollo, Valeria; Gallo, Grazia; Artali, Roberto; Dallavalle, Sabrina; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 462 – 466;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

59434-19-4,59434-19-4, 4-Aminophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7A(is)-4-(Benzylideneamino)isobenzofuran- 1 (3H)-one[00485] 4-aminoisobenzofuran- l(3H)-one (600 mg, 4 mmol), benzaldehyde (427 mg, 4 mmol) were added to methanol (20 mL) and stirred under reflux overnight, then the mixture was evaporated under reduced pressure and the residue was dried in vacuum. 600 mg of crude product (E)-4- (benzylideneamino)isobenzofuran- 1 (3H)-one was obtained which was used for the next synthetic step without further purification.

The synthetic route of 59434-19-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

1914-60-9 2,3-Dihydrobenzofuran-2-carboxylic acid 2776555, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7169-34-8, General procedure: Coumaranone (1.00mmol) and aldehyde (1.00mmol) were combined in a dry vial. 3.5g of neutral alumina was then added followed by 5ml of dichloromethane. The reaction mixture was stirred for 12h at 25C. The reaction mixture was then filtered and the dichloromethane layer collected and concentrated to dryness in vacuo. Further purification was performed as noted.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Park, Hyo S.; Nelson, David E.; Taylor, Zachary E.; Hayes, James B.; Cunningham, Kirsten D.; Arivett, Brock A.; Ghosh, Rajarshi; Wolf, Larissa C.; Taylor, Kimberley M.; Farone, Mary B.; Handy, Scott T.; Farone, Anthony L; International Immunopharmacology; vol. 43; (2017); p. 116 – 128;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem