Category: 209256-42-8

209256-42-8, 2,3-Dihydrobenzofuran-4-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1050 mL (1.05 mol) of a 1.0 M solution of vinyl magnesium bromide in tetrahydrofuran was added to the reaction flask, the stirring was started, the reaction solution was cooled to -10 to -5 C, and 2,3-dihydrobenzofuran-4 was added dropwise. -A solution of formaldehyde (148.2 g, 1.00 mol) in tetrahydrofuran (500 mL), and the temperature of the reaction solution is controlled to not exceed -5 C. After the completion of the dropwise addition, the reaction was maintained at a temperature of -10 to -5 C for half an hour, and then slowly warmed to room temperature to continue the reaction. After 6 hours, 300 mL of a saturated ammonium chloride aqueous solution was added, and after stirring for 30 minutes, extraction was performed with ethyl acetate three times (800 mL ¡Á 3). The organic phase was washed once with a saturated sodium chloride solution (300 mL) and water (300 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to dryness under reduced pressure to obtain 173.6 g of a yellow oil with a yield of 98.5%., 209256-42-8

The synthetic route of 209256-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Changzhou Yabang Pharmaceutical Co., Ltd.; Chen Zaixin; Ji Xiaolong; Xia Zhengjun; Zang Lujie; Xia Lingxian; Hao Jinxing; Wang Fan; (12 pag.)CN104926763; (2019); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.

D. trans-3-(2,3-Dihydro-4-benzofuranyl)-2-pronenoic acid A solution of 2,3-dihydrobenzofuran-4-carboxaldehyde (8.42 g, 56.9 mmol) and malonic acid (11.86 g, 114 mmol) in pyridine (30 mL) and pyrrolidine (1 mL) was heated at reflux for 6 hr. The solution was cooled and poured into cold water (400 mL). The mixture was made strongly acidic with 12 N HCl to give a pale yellow precipitate that was filtered and air dried. The pale yellow powder was recrystallized from isopropanol to give white flakes (10.3 g, 95.3%, mp: 205-207C). Anal. for C11H10O3: Calc’d, C, 69.46; H, 5.30. Found, C, 69.36; H, 5.17. 1H NMR (300 MHz, CDCl3) delta7.76 (d, 1H, J=16.1 Hz), 7.15 (t, 1H, J=7. 8 Hz), 7.07 (d, 1H, J=7.8 Hz), 6.81 (d, 1H, J=7.8 Hz), 6.37 (d, 1H, J=16.1 Hz), 4.62 (t, 2H, J=8.8 Hz), 3.33 (t, 2H, J=8.8 Hz)., 209256-42-8

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP1041980; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

209256-42-8, 2,3-Dihydrobenzofuran-4-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirring solution of the aldehyde from step A Example 33 (400 mg, 2.7 mmol) in dichloromethane (40 mL) was added carbethoxymethylene-triphenylphosphorane (1.41 g, 4.05 mmol). The reaction was refluxed for 16 hrs. and the solvent was removed in vacuo. The title compound (white solid, 533 mg, 91% yield) was isolated from a silica gel column using 20% ethyl acetate in hexanes as the eluent., 209256-42-8

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US6887870; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.,209256-42-8

To a solution of 2,3-dihydrobenzofuran-4-aldehyde (1g, 6.7 mmol) (Example 2, Part C) and dimethyl malonate 0.89 g, 6.7 mmol) in benzene (30 mL) was added piperidine (0.11 g, 1.4 mmol) and acetic acid (0.40 g, 6.7 mmol). The resulting solution was stirred for 18 hr with continuous removal of water. The solution was cooled to ambient temperature and concentrated. The residues was chromatographed on silica gel (ethyl acetat:hexane, 3:7) to give the title compound (1.5g).

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP1041980; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.

209256-42-8, 2,3-dihydrobenzofuran-4-carbaldehyde (2.00 g, 13.5 mmol) was dissolved in dry MeOH (30 mL) and the solution cooled to 0 C. NaBH4 (510 mg, 13.5 mmol) was added and the solution stirred at room temperature for 1 hour. Ice water was added and the layers separated. The organicphase was evaporated in vacuo to yield the title compound as colourless crystalline solid (1.90 g, 94%).[00292] AnalpH2_MeOH_4MIN: Rt: 2.00 mm, mlz 151.3 [M+H]+

As the paragraph descriping shows that 209256-42-8 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY OF LEEDS; PHILIPPOU, Helen; FOSTER, Richard; FISHWICK, Colin; REVILL, Charlotte; YULE, Ian; TAYLOR, Roger; NAYLOR, Alan; FALLON, Philip, Spencer; CROSBY, Stuart; HOPKINS, Anna; GUETZOYAN, Lucie, Juliette; MACNAIR, Alistair, James; STEWART, Mark, Richard; WINFIELD, Natalie, Louise; (273 pag.)WO2019/186164; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.

To a solution of the aldehyde A (1.0 g, 6.75 mmol) in dichloromethane (40 mL) was added triphenylphosphoranylidene-2-propanone (3.2 g, 10.12 mmol). The reaction was refluxed for 16 hrs and the solvent was removed in vacuo. The title compound (white solid, 1.86 g, 99% yield) was purified via silica gel chromatography using 5% ethyl acetate in hexanes as the eluent.

209256-42-8, 209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Bristol-Myers Squibb Company; US6887870; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem