209256-42-8, 2,3-Dihydrobenzofuran-4-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1050 mL (1.05 mol) of a 1.0 M solution of vinyl magnesium bromide in tetrahydrofuran was added to the reaction flask, the stirring was started, the reaction solution was cooled to -10 to -5 C, and 2,3-dihydrobenzofuran-4 was added dropwise. -A solution of formaldehyde (148.2 g, 1.00 mol) in tetrahydrofuran (500 mL), and the temperature of the reaction solution is controlled to not exceed -5 C. After the completion of the dropwise addition, the reaction was maintained at a temperature of -10 to -5 C for half an hour, and then slowly warmed to room temperature to continue the reaction. After 6 hours, 300 mL of a saturated ammonium chloride aqueous solution was added, and after stirring for 30 minutes, extraction was performed with ethyl acetate three times (800 mL ¡Á 3). The organic phase was washed once with a saturated sodium chloride solution (300 mL) and water (300 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to dryness under reduced pressure to obtain 173.6 g of a yellow oil with a yield of 98.5%., 209256-42-8
The synthetic route of 209256-42-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Changzhou Yabang Pharmaceutical Co., Ltd.; Chen Zaixin; Ji Xiaolong; Xia Zhengjun; Zang Lujie; Xia Lingxian; Hao Jinxing; Wang Fan; (12 pag.)CN104926763; (2019); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem