Day: November 20, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

A schlenk tube was charged with boronic acid 15 (152 mg, 1.25 mmol, 1.25 equiv), Pd(PPh3)4(57.5 mg, 0.0500 mmol, 0.05 equiv), Na2CO3 (265 mg, 2.50 mmol, 2.50 equiv), DME (1.5mL) and H2O (3.5 mL). After degassing the mixture, 5-bromobenzofuran (7c) (196 mg, 1.00mmol, 1.0 equiv) was added. The mixture was heated to 90 C and stirred overnight under N2. Then, the mixture was filtered through a plug of celite, and diluted with CH2Cl2 (10 mL). Theorganic layer was washed with 1 M NaOH (10 mL), brine (10 mL), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by columnchromatography (SiO2; pentane) to afford 7d as a white solid (174 mg, 0.900 mmol, 90%).Rf (pentane): 0.6.1H NMR (400 MHz, CDCl3) delta 7.82 (d, 1 H, J = 1.4 Hz; FuranH), 7.68 (d, 1 H, J = 2.2 Hz;ArH), 7.65 (dd, 2 H, J = 8.5, 1.3 Hz, ArH), 7.60 (d, 1 H, J = 8.5 Hz; ArH), 7.56 (dd, 1 H, J =8.6, 1.3 Hz, ArH), 7.48 (t, 2 H, J = 7.4 Hz, ArH), 7.38 (t, 1H, J = 7.4 Hz; ArH) 6.84 (d, 1 H, J= 1.4 Hz; FuranH) 13C NMR (101 MHz, CDCl3) delta 154.5, 145.6, 141.6, 136.4, 128.7, 127.9,127.4, 126.8, 123.9, 119.7, 111.5, 106.8. The NMR data correspond to the literature., 23145-07-5

The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Yifan; Waser, Jerome; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1763 – 1767;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A three-neck 5 L round bottomed flask equipped with a stir bar, firestone valve, thermocouple, condenser and heating mantle was charged with tri-t-butyl phosphonium tetrafluoroborate (500 mg, 1.72 mmol), palladium (II) acetate (250 mg, 1.1 mmol) and 5-bromo-2-benzofuran-1(3H)-one (100 g, 470 mmol). DMF (1.88 L) was added to the flask, and the mixture was degassed three times by alternating vacuum and nitrogen purge. Commercially available bromo(1,3-dioxolan-2-ylmethyl)zinc solution (1.03 L, 516 mmol) was added via cannula and the mixture was again degassed three times. The mixture was then heated at 85 C. for 5 hr. Analysis by HPLC-MS indicated the reaction was not complete. The mixture was stirred at 85 C. for 5 more h. The mixture was then cooled to return to room temperature for overnight. 2-MethylTHF (2 L) and brine were added, and the mixture was stirred for 5 min. The layers were separated and the aqueous layer was extracted again with 2-methylTHF. The organic layers were combined, washed three times with brine (4 L each), dried over MgSO4, filtered, and concentrated. The crude product was purified by flash chromatography (1.5 kg silica cartridge), eluting with 0-20% ethyl acetate in dichloromethane to afford the title compound. MS [M+H]+=221.

64169-34-2, 64169-34-2 5-Bromoisobenzofuran-1(3H)-one 603144, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Corp.; Biswas, Dipshikha; Ding, Fa-Xiang; Dong, Shuzhi; Gu, Xin; Jiang, Jinlong; Pasternak, Alexander; Suzuki, Takao; Vacca, Joseph; Xu, Shouning; (81 pag.)US2017/37037; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6296-53-3,N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide,as a common compound, the synthetic route is as follows.,6296-53-3

A stirred mixture of 5-amino-5-(3-ethoxy-4-methoxyphenyl)pentan-3-ol hydrochloride(1.15 g, 3.97 mmol), 3-acetamidophthalic anhydride (0.82 g, 3.97 mmol) and triethylamine (0.4 g, 3.97 mmol) in DMF (20 ML) was heated at 80-90¡ã C. for 6 hours. The mixture was then concentrated in vacuo. The residue was dissolved in ethyl acetate (80 ML), washed with water (30 ML), brine (30 ML) and dried over magnesium sulfate. The solvent was removed in vacuo and the residue was purified by chromatography (silica gel, methylene chloride:ethyl acetate 8:2) to give N-{2-[1-(3-ethoxy-4-methoxyphenyl)-3-hydroxypentyl]-1,3-dioxoisoindolin-4-yl}acetamide (1.35 g, 77percent); 1H NMR (CDCl3) delta9.52 (s, 1H), 8.71 (d, J=8.4 Hz, 1H), 7.63 (t, J=7.6 Hz, 1H), 7.48 (d, J=7.3 Hz, 1H), 7.09-7.07 (m, 2H), 6.83-6.80 (m, 1H), 5.61-5.55 (J=3.9, 11.9 Hz, 1H), 4.11 (q, J=6.9 Hz, 2H), 3.84 (s, 3H), 3.47 (m, 1H), 2.97-2.86 (m, 1H), 2.25 (s, 3H), 2.06-1.95 (m, 1H), 1.78 (b, 1H), 1.62-1.52 (m, 2H), 1.45 (t, J=7.0 Hz, 3H), 0.95 (t, J=7.3 Hz, 3H); 13C NMR (CDCl3) delta170.39, 169.23, 168.11, 148.94, 148.14, 137.32, 135.83, 131.81, 131.19, 124.72, 120.30, 117.94, 115.31, 112.87, 111.09, 70.01, 64.36, 55.86, 51.29, 37.92, 30.46, 24.92, 14.73, 9.90.

6296-53-3 N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide 226121, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Celgene Corporation; US6667316; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

To a solution of 2,3-dihydrobenzofuran (1 g, 8.3mmol) in DCM (10mL) was added acetyl chloride (1.3g, 16.6mmol) and AICI3 (3.3g, 24.6mmol) slowly at -10C. The reaction mixture was stirred at -10C for 3h. The TLC showed the reaction to be complete. The reaction mixture was diluted with 5% aqueous HCI (10ml_) and extracted with DCM (3×1 OmL). The combined organic layers were washed with saturated aqueous bicarbonate solution (100ml_), brine (100ml_), dried (Na2S04), filtered and concentrated under reduced pressure to afford 1-(2,3- dihydrobenzofuran-5-yl)ethan-1-one as a brown liquid. Yield: 1.34g (97%); MS (ESI+) for CHNOS m/z 163.0[M+H]+; 1 H NMR (400 MHz, CDCI3): <5 7.86 (s, 1 H), 7.79 (d, J = 8.4Hz, 1 H), 6.80 (d, J = 8.4 Hz, 1 H), 4.66 (t, J = 8.8 Hz, 2H), 3.25 (t, J = 8.8 Hz, 2H), 2.52 (s, 3H)., 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

The synthetic route of 1914-60-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

942-06-3, 4,5-Dichlorophthalic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.1.20 5,6-Dichlorophthalide (41) Anhydride 40 (9.53 g, 42.6 mmol) was dissolved with stirring in THF (80 mL) and the solution was cooled to 0 ¡ãC under an Ar atmosphere. NaBH4 (1.63 g, 43.1 mmol) was added slowly in a single portion, and the mixture was stirred with cooling to 0 ¡ãC for 50 min. The mixture was removed from the ice-water bath and warmed to room temperature for 17 h. MeOH (20 mL) was added slowly and cautiously to the obtained suspension. The mixture was concentrated in vacuo. Dilute, aqueous HCl (0.1 M, 24 mL) was added to the residue. After stirring the mixture for 10 min, it was filtered. The collected solids were vigorously heated at reflux in PhMe (100 mL) with pTsOH¡¤H2O (0.15 g), using a Dean-Stark trap to collect H2O, for 30 h 15 min. The mixture was concentrated in vacuo. The residue was washed with H2O (50 mL) and the solid was azeotroped with PhMe (10 mL) and dried under high vacuum to provide 41 (6.41 g, 74percent) as a white solid, Rf (SiO2, CHCl3) 0.55: mp 157-160 ¡ãC. 1H NMR (300 MHz, DMSO-d6) delta 8.14 (s, 1H), 8.04 (s, 1H), 5.40 (s, 2H); CIMS m/z (rel intensity) 203/205/207 (MH+, 100/71/14)., 942-06-3

942-06-3 4,5-Dichlorophthalic Anhydride 70334, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Beck, Daniel E.; Lv, Wei; Abdelmalak, Monica; Plescia, Caroline B.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1469 – 1479;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69604-00-8,Ethyl 5-nitrobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

69604-00-8, Ethyl 2-nitrobenzofuran-2-carboxylate (23.5 g) prepared according to Example 4 was added to a reaction flask, 200 ml of ethanol was added, 3 g of 5% palladium carbon was added, and the mixture was replaced with hydrogen 3 times.The hydrogen pressure was controlled to be 0.4-0.5 MPa, hydrogenation reaction was performed at 30 C. for 3 hours, the reaction was completed, and the reaction was filtered. The filtrate was concentrated under reduced pressure to dryness to obtain 19.5 g of 5-aminobenzofuran-2-carboxylic acid ethyl ester.Yield 95.1%, purity 98.8%.

69604-00-8 Ethyl 5-nitrobenzofuran-2-carboxylate 1382954, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Lianyungang Hengyun Pharmaceutical Co., Ltd.; Dong Shuqiu; Feng Ruimao; Zhang Qingjie; (8 pag.)CN107540646; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a 50mL round-bottom flask containing 5mL acetone,anhydrous K2CO3 (0.5mmol), compound 2 (0.5mmol) andsubstituted phenol or benzenethiol (0.5mmol) were addedand reacted at room temperature under N2. When the reactionwas complete (TLC control), the organic solvent wasremoved, followed by addition of water (20mL). The solutionwas extracted with ethyl acetate (EtOAc) (3¡Á30mL).Finally, the resulting organic phases was washed withbrine, dried over anhydrous Na2SO4 and evaporated underreduced pressure. The crude material was purified bysilica gel column chromatography to give desired products3a-j and 4a-m, which were characterized by 1H NMR, 13CNMR and HRMS.

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Article; Fan, Lingling; Luo, Bilan; Luo, Zhongfu; Zhang, Li; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong; Zeitschrift fur Naturforschung, B: Chemical Sciences; (2019);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection conditions, 5 mL of anhydrous dichloromethane was added3-methylbenzofuran-2-carboxylic acid (19 mg, 0.11 mmol)After stirring at room temperature, HOBt (18 mg, 0.13 mmol) was added,After stirring for 10 minutes, EDC ¡¤ HCl (25 mg,0.13 mmol) followed by the addition of compound III-8-a of Example 6(50 mg, 0.17 mmol) and DIPEA (0.04 mL, 0.22 mmol)TLC after 12 hours showed complete reaction,The reaction solution was washed with 5% NaHCO3 solution, 10% citric acid solution,5% NaHCO3 solution and saturated brine,Adding to the organic phase anhydrous sodium sulfate drying, drying and filtering,The solvent was removed using a rotary evaporator and the product was added directly to 5 mL of methanol,After stirring at room temperature, 2-methylpropylboronic acid (22 mg, 0.22 mmol) was added5 mL of n-hexane, followed by the addition of 1 M HCl solution (0.33 mL, 0.33 mmol)After 5 hours, the TLC assay showed complete reaction, the reaction solution was allowed to stand,The lower layer was washed with n-hexane, dried over anhydrous sodium sulfate,Drying after filtration, the use of rotary evaporator in addition to solvent,Column chromatography (dichloromethane: methanol = 60: 1) gave 16 mg of a white solid,Yield 50%.

24673-56-1, The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Shao Liming; Xu Yulong; Chen Yiyi; Li Wei; Xie Qiong; (36 pag.)CN107151255; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

57319-65-0, A solution of 400 mg (1.44 mM) of 4-chloro-6,7-diethoxy-quinoline-3-carbonitrile, 230 mg (1.54 mM) of 6-Aminophthalide and 161 mg of pyridine hydrochloride in 12 ml of 2-methoxyethanol was refluxed for 3 hours. To the warm solution was added 1 ml of 1M sodium carbonate and the sample was heated for 5 minutes at 100C, then poured into 300 ml of ice water. The solid was collected, washed with water followed by ether and dried under vacuum at 80C to yield 535 mg of 6,7-Diethoxy-4-(3-oxo-1,3-dihydro-isobenzofuran-5-ylamino)-quinoline-3-carbonitrile as a white solid: mass spectrum (electrospray, m/e): M+H 390.1, mp = 280-284C.

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth Holdings Corporation; EP1117659; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem