64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A three-neck 5 L round bottomed flask equipped with a stir bar, firestone valve, thermocouple, condenser and heating mantle was charged with tri-t-butyl phosphonium tetrafluoroborate (500 mg, 1.72 mmol), palladium (II) acetate (250 mg, 1.1 mmol) and 5-bromo-2-benzofuran-1(3H)-one (100 g, 470 mmol). DMF (1.88 L) was added to the flask, and the mixture was degassed three times by alternating vacuum and nitrogen purge. Commercially available bromo(1,3-dioxolan-2-ylmethyl)zinc solution (1.03 L, 516 mmol) was added via cannula and the mixture was again degassed three times. The mixture was then heated at 85 C. for 5 hr. Analysis by HPLC-MS indicated the reaction was not complete. The mixture was stirred at 85 C. for 5 more h. The mixture was then cooled to return to room temperature for overnight. 2-MethylTHF (2 L) and brine were added, and the mixture was stirred for 5 min. The layers were separated and the aqueous layer was extracted again with 2-methylTHF. The organic layers were combined, washed three times with brine (4 L each), dried over MgSO4, filtered, and concentrated. The crude product was purified by flash chromatography (1.5 kg silica cartridge), eluting with 0-20% ethyl acetate in dichloromethane to afford the title compound. MS [M+H]+=221.
64169-34-2, 64169-34-2 5-Bromoisobenzofuran-1(3H)-one 603144, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Merck Sharp & Dohme Corp.; Biswas, Dipshikha; Ding, Fa-Xiang; Dong, Shuzhi; Gu, Xin; Jiang, Jinlong; Pasternak, Alexander; Suzuki, Takao; Vacca, Joseph; Xu, Shouning; (81 pag.)US2017/37037; (2017); A1;,
Benzofuran – Wikipedia
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