Day: November 19, 2020

61090-37-7, 2,3-Dihydrobenzofuran-4-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2,3-dihydro-4-benzofuranamine (72.3 g, 0.54 mol), hydroxylamine hydrochloride (131.3 g, 1.8 mol), conc. hydrochloric acid (45 mL) and water (1265 mL) was stirred at room temperature for 30 min. A solution of chloral hydrate (98.2 g, 0.59 mol) in water (1265 mL) was added followed by solid sodium sulphate (767 g, 5.4 mol) and the reaction was heated to reflux for 1 h. The reaction was cooled to room temperature and the solid was collected by filtration. The solid was suspended in ethyl acetate (250 mL) and water (250 mL) and then extracted with ethyl acetate (3*250 mL). The organic extracts were combined, dried (magnesium sulphate) and concentrated in vacuo to afford the title compound (41 g, 38%) as a pale brown solid; NMR (400 MHz, DMSO-d6) deltaH 3.12 (2H, t, J 9.0 Hz), 4.52 (2H, t, J 8.5 Hz), 6.58 (1H, d, J 8.0 Hz), 7.06 (1H, t, J 8.5 Hz), 7.14 (1H, d, J 8.5 Hz), 7.7 (1H, s), 9.66 (1H, br s), 12.19 (1H, br s); IR numax (Nujol)/cm-1 3389, 3160, 2923, 1661, 1620, 1607, 1540, 1453, 1238, 1060, 1029, 982 and 780., 61090-37-7

The synthetic route of 61090-37-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERNALIS RESEARCH LIMITED; US2005/187282; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13391-28-1,5-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a reaction tube were added 20 mol % CuI, 20 mol % KI (or Xphos), 0.25 mmol heterocycles, 3.0 equiv DTBP, and 1.5 mL cyclic ethers under a nitrogen atmosphere. The resulting mixture was heated at 120 C. After 24 h, the solvent was removed under vacuum, and the residue was purified by flash chromatography (SiO2, petroleum ether/ethyl acetate10:1)., 13391-28-1

13391-28-1 5-Methoxybenzofuran 25943, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Chenyang; Gong, Ming; Huang, Mengmeng; Li, Yabo; Kim, Jung Keun; Wu, Yangjie; Tetrahedron; vol. 72; 49; (2016); p. 7931 – 7936;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 2,3-Dihydrobenzofuran-5-amine (1A) (2.0g, 14 . 80mmol) is added to the hydrochloric acid in (14.6 ml, 3N), cooling to -5 ¡ãC, dropping sodium nitrite (1.2g, 17 . 80mmol) of water (8 ml) solution, after dripping, in 0 ¡ãC reaction 30 minutes, slowly adding sodium acetate (2.1g, 25 . 6mmol), adjusting reaction solution pH=5-6, in 0-5 ¡ãC lower, dropping ethyl 2-chloroacetoacetate(2.4g, 14 . 80mmol) methanol (5 ml) solution, to reaction at room temperature 2 hours. Adding ethyl acetate to the reaction solution (20 ml), liquid, organic phase with saturated salt water (30 ml) washing, dry anhydrous sodium sulfate, filtered, concentrated under reduced pressure, the residue is purified by silica gel column chromatography (ethyl acetate/petroleum ether (v/v) =1:99-1:9) to obtain the title compound ethyl 2-chloro-2-(2-(2,3-dihydrobenzofuran-5-yl)hydrazono)acetate(1B), yellow solid (200 mg, yield 5percent).

42933-43-7, As the paragraph descriping shows that 42933-43-7 is playing an increasingly important role.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) was heated at reflux in SOCl2 (5?10 equiv) for 4 h at 100 ¡ãC. The remaining SOCl2 was removed in vacu-um and the obtained solid was dissolved in CH2Cl2 (10 mL). The mix-ture was cooled to 0 ¡ãC and the desired primary amine (2.0 equiv)was slowly added. The solution was stirred for 24 h at r.t. then thereaction mixture was diluted with EtOAc (70 mL), washed with citricacid (0.5 M), sat. aq Na2CO3 solution, and brine. The organic layer wasdried over MgSO4 and the solvent was removed under reduced pres-sure. The obtained products were used without further purification.

16859-59-9, 16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

189035-22-1, 6-Bromo-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 7 (4.29 g, 21.6 mmol) in THF (43 mL) was added 1.76 M t-BuLi in pentane (25.7 mL, 45.2 mmol) under Ar at -74 C. Paraformaldehyde (0.97 g, 32.3 mmol) was added to the mixture at -74 C and the mixture was stirred at room temperature overnight. The mixture was quenched with satd NH4Cl aq and extracted with AcOEt. The organic layer was washed with brine and dried over MgSO4, then filtered. After removal of the solvent, the residue was recrystallized from CH2Cl2 (6.5 mL) and n-hexane (25.9 mL) to obtain 8 as a pale red solid (2.39 g, 74%). 1H NMR (400 MHz, CDCl3) delta = 7.16 (d, J = 7.2 Hz, 1H), 6.84 (d, J = 7.2 Hz, 1H), 6.81 (s, 1H), 4.63 (br s, 2H), 4.58 (t, J = 8.8 Hz, 2H), 3.20 (t, J = 8.8 Hz, 2H); MS (ESI+) 151.1 (M+H)+., 189035-22-1

As the paragraph descriping shows that 189035-22-1 is playing an increasingly important role.

Reference£º
Article; Takahashi, Bitoku; Funami, Hideaki; Iwaki, Takehiko; Maruoka, Hiroshi; Shibata, Makoto; Koyama, Makoto; Nagahira, Asako; Kamiide, Yoshiyuki; Kanki, Satomi; Igawa, Yoshiyuki; Muto, Tsuyoshi; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4792 – 4803;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87-41-2,Isobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

NBS (53.4 g, 300 mmol, 1.5 eq) was added portion wise to a solution of phthalide (Sl-I) (26.83 g, 200 mmol. 1 O eq) in a mixture of TFA (100 mL) and sulfuric acid (45 mL) at rt over 9 h. The reaction mixture (an orange solution) was stirred at rt for about 60 h. (Crude NMR showed the reaction is complete.) Then the reaction mixture was poured onto ice, extracted with methylene chloride (3 x 300 mL). The combined organic phase was dried over MgSO4, filtered and concentrated to afford a yellow solid. The residue was purified by flash-column chromatography (5-10% ethyl acetate-hexanes) to afford the desired product Sl-2 (white solid, 28.17g, 66%) and the other regioisomer S3-1 (white solid, 12.7g, 30%). 1H NMR (400 MHz, CDCl3) 8 8.04 (d, J= 1.8 Hz, 1 H), 7.78 (dd, J= 1.8, 7.9 Hz, 1 H), 7.37 (d, J= 7.9 Hz, 1 H), 5.26 (s, 2 H)., 87-41-2

87-41-2 Isobenzofuran-1(3H)-one 6885, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; TETRAPHASE PHARMACEUTICALS, INC.; CLARK, Roger, B.; HUNT, Diana, Katharine; PLAMONDON, Louis; SUN, Cuixiang; XIAO, Xiao-Yi; ROeNN, Magnus; WO2010/132670; (2010); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55745-70-5,2,3-Dihydrobenzo[b]furan-5-carbaldehyde,as a common compound, the synthetic route is as follows.

(a) 7-bromo-2,3-dihydro-l-benzofuran-5-carbaldehydeTo a solution of 2,3-dihydro-l-benzofuran-5-carbaldehyde (1.0 g, 6.75mmol) in glacial aGetic acid (8 ml) was added sodium acetate (664mg, 8.1mmol) and bromine (0.7ml, 13.5mmol) at 10C slowly. The reaction was stirred for 2h at room temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 ml), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%). MS (+ve ion electrospray): m/z 227 (M+H)+.

55745-70-5, 55745-70-5 2,3-Dihydrobenzo[b]furan-5-carbaldehyde 735901, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/71936; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57319-65-0, 2,2,2-trichloroethyl (3-oxo-1,3-dihydroisobenzofuran-5-yl)carbamate 2 To a suspension of 6-aminoisobenzofuran-1(3H)-one 1 (Maybridge, 13.43 g, 90 mmol) in dichloromethane (DCM, 200 mL) at 0 C. was added 2,2,2-trichloroethyl carbonochloridate 1a (18.23 mL, 135 mmol) and pyridine (17.79 mL, 180 mmol). The reaction mixture was stirred at room temperature (RT, ca. 25 C.) for 1 h. Thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) showed the reaction was complete. The reaction mixture was filtered and washed with DCM (2*30 mL) to afford carbamate 2 as a white solid (17.03 g, 58%). LCMS: [M+l]=324.

57319-65-0 6-Aminoisobenzofuran-1(3H)-one 93631, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; CHOWDARI, Naidu S.; Gangwar, Sanjeev; Sufi, Bilal; US2013/209494; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196799-45-8,2,3-Dihydrobenzofuran-7-carbaldehyde,as a common compound, the synthetic route is as follows.,196799-45-8

(R)-2-(9-(pyridin-2-yl)-6-dioxaspiro[4.5]decane-9-yl)ethylamine (Intermediate 1)(0.260 g, 1.0 mmol) was dissolved in dichloromethane (10 mL)Further sodium sulfate (0.71 g, 5.0 mmol)And 2,3-dihydrobenzofuran-7-formaldehyde (74B) (0.18 g, 1.2 mmol)The reaction was added and the reaction was continued overnight at room temperature. Sodium borohydride (0.06 g, 1.2 mmol)After the reaction was added, the reaction was stirred for 10 minutes, and then methanol (10 mL) was added.The reaction was stirred for 1 hour. The reaction was quenched with water and the aqueous phase was treated with dichloromethane.Extraction of the alkane (20 mL ¡Á 3), combining the organic phases,Wash with saturated sodium chloride solution (30 mL), dry over anhydrous sodium sulfate and filtered. After the filtrate is concentrated, the crude product is purified by column chromatography (dichloromethane/methanol (v/v) = 50:1 to 20:1) to give a yellow oily liquid.(R)-N-((2,3-dihydrobenzofuran-7-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decane- 9-yl)ethylamine (74C)(0.18 g, yield: 45.9%).

196799-45-8 2,3-Dihydrobenzofuran-7-carbaldehyde 2795018, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem