Day: November 9, 2020

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,610-93-5

(a) 3-Hydroxy-6-nitro-1(3H)-isobenzofuranone (3a) A mixture of 6-nitro-1(3H)-isobenzofuranone (8.99 g, 50.0 mmol) and N-bromosuccinimide (8.9 g, 50.0 mmol) in carbon tetrachloride (135 mL) was stirred and heated under reflux for one hour during which time the reaction mixture was exposed to the light from a 275 Watt, 125 Volt Hanovia sunlamp that was situated 8 inches from the flask. After cooling, the succinimide was removed by filtration, and the filtrate was evaporated in vacuo. The oily residue was mixed with water (200 mL), and the mixture was refluxed for one hour to give a clear, colorless solution. On cooling, the Compound 3a crystallized from solution. An analytical sample was prepared by recrystallization from water; m.p. 157-160 C.; IR 3390 cm-1 (OH), 1770 cm-1 (C=O), 1 H NMR (CDCl3 -Me2 SO-d6 -D2 O) delta6.78 (s, br, 1H, H3), 7.88 (d, 1H, H4, J4,5 =9 Hz), 8.56 (d, 1H, H5, J=9 Hz), 8.62 (s, 1H, H6). Anal. Calcd. for C8 H5 NO5: C, 49.24; H, 2.58; N, 7.18; Found: C, 49.39; H, 2.58; N, 7.13.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US4591587; (1986); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, Under argon, 10.0 g (60.2 mmol) of 4-fluoro-2-benzofuran-1,3-dione were stirred at 130¡ã C. in 50 ml of formamide for 1 h. The cooled reaction mixture was then added to ice-water. A solid precipitated out. This solid was filtered off with suction and washed with water. The product was dried under high vacuum. This gave 8.3 g (83percent of theory) of the target compound.LC-MS (method 11): Rt=0.57 min; m/z=166 (M+H)+.1H-NMR (400 MHz, DMSO-d6): delta=11.47 (br. s, 1H), 7.87 (td, 1H), 7.69-7.61 (m, 2H).

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIEGESELLSCHAFT; US2011/34450; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87-41-2,Isobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

6-Nitroisobenzofuran-1(3H)-one To a stirred solution of 3H-isobenzofuran-1-one (30.0 g, 0.220 mol) in H2SO4 (38 mL) was added KNO3 (28.0 g, 0.290 mol) in H2SO4 (60 mL) at 0 C. The mixture was stirred at 20 C. for 1 h. The reaction mixture was poured into ice and the resulting precipitate was filtered off. The solid was recrystallized from ethanol to give 6-nitroisobenzofuran-1(3H)-one (32.0 g, 80%). 1H NMR (300 MHz, CDCl3) delta 8.76 (d, J=2.1, 1H), 8.57 (dd, J=8.4, 2.1, 1H), 7.72 (d, J=8.4, 1H), 5.45 (s, 2H).

87-41-2, The synthetic route of 87-41-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; Van Goor, Fredrick F.; Burton, William Lawrence; US2015/231142; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

32703-79-0, 5-(tert-Butyl)isobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Zinc phthalocyanine (6) (40 mg, 0.05 mmol) and pyridine.HCl (1 g, 8.7 mmol) were dissolved in 5 mL of pyridine and the mixture was refluxed under N2 for 16 h. After the reaction mixture was cooled to room temperature, 10 mL of water was added and the product was precipitated. The precipitate was washed first with water and then with methanol. After drying in vacuo the product was puried by column chromatography on silica gel by using ethyl acetate/hexane (1/3) eluent. The product was obtained as a dark blue solid. Yield 74%, FTIR ( , cm1) : 3283, 3071, 2956, 2907, 2866, 1617, 1485, 1258, 1089, 1000, 827, 741.1H NMR (500 MHz, CDCl3) : , ppm 9.14{8.62 (8H, m, Pc-H), 8.17{8.04 (4H, m, Pc-H), 1.94{1.89 (36H, m,C-(CH3)3) , {2.67{ {3.46 (2H, m, N-H), MS: m/z 747.079 [M+H]+., 32703-79-0

32703-79-0 5-(tert-Butyl)isobenzofuran-1,3-dione 122930, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Atsay, Arma?an; Guel, Ahmet; Burkut Kocak, Makbule; Turkish Journal of Chemistry; vol. 40; 1; (2016); p. 163 – 173;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

54008-77-4,54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A solution of 4-fluoroisobenzofuran-1,3-dione (200 mg, 1.20 mmol, 1 equiv) in AcOH (4.0mL, 0.3 M)was added 2,6-dioxopiperidin-3-amine hydrochloride (218 mg, 1.32 mmol, 1.1 equiv)and potassium acetate (366 mg, 3.73 mmol, 3.1 equiv). The reaction mixture was heated to 90 C overnight, whereupon it was diluted with water to 20 mL and cooled on ice for 30 mm. The resulting slurry was filtered, and the black solid was purified by flash column chromatography on silica gel (2% MeOH in CH2C12, Rf = 0.3) to afford the title compound as a white solid (288 mg,86%). 1H NMR (500 MHz, DMSO-d6) 11.15 (s, 1H), 7.96 (ddd,J= 8.3, 7.3, 4.5 Hz, 1H), 7.82-7.71 (m, 2H), 5.17(dd,J= 13.0, 5.4 Hz, 1H), 2.90(ddd,J= 17.1, 13.9, 5.4 Hz, 1H), 2.65 -2.47 (m, 2H), 2.10-2.04 (m, 1H), MS (ESI) cald for C13H10FN2O4 [M+H] 277.06, found 277.25.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ROBERTS, Justin; BEHMAN, Nabet; WINTER, Georg; PHILLIPS, Andrews, J.; HEFFERNAN, Timothy, P.; BUCKLEY, Dennis; (617 pag.)WO2018/148440; (2018); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

19477-73-7, 6-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To 2 dram, stir-bar equipped vials, were added the aryl bromides (1.0 equiv). A stock solution of Ir[dF(CF3)ppy]2(dtbbpy)PF6 (1.0 mol%) and carboxylic acid 5 (1.1 equiv) in DMF (0.15 M with respect to carboxylic acid 5) was prepared, and to this stock solution was added TMG (1.1 equiv). The resulting stock solution was kept under a blanket of nitrogen. A separate solution of [Ni(dtbbpy)(H2O)4]Cl2 (10 mol%) in DMF (0.04 M) was prepared. The stock solution of Ir cat./acid/TMG was added to the aryl bromide monomers, followed by the Ni stock solution. The reaction mixtures were purged by blowing nitrogen over the top, sealed, and irradiated with blue LED (34 W LED Kessil lamps) for 24 h at room temperature. The reaction mixtures were diluted with EtOAc (3 mL) and H2O (4 mL). The organic layer was separated and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography with a solvent gradient from 0%EtOAc/hexanes to 100% EtOAc/hexanes to deliver the title compound.

19477-73-7, As the paragraph descriping shows that 19477-73-7 is playing an increasingly important role.

Reference£º
Article; Suen, Linda M.; Wang, Cheng; Hunter, David N.; Mitchell, Helen J.; Converso, Antonella; Elmarrouni, Abdellatif; Synthesis; vol. 50; 16; (2018); p. 3177 – 3186;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.,81742-10-1

General procedure: A mixture of compound 14 (1 g, 6.7 mmol) and 3,6-dichlorotrimellitic anhydride (875 mg, 3.35 mmol) in 5 mL polyphosphoric acid is heated to 180 C. overnight. After cooling to room temperature, the mixture is poured into ice/water, and stirred for 30 min. The resulting precipitate is filtered, washed with water, and dried under vacuum. The crude product is purified on silica gel using CH2Cl2/MeOH. Yield: 438 mg (25%).

81742-10-1 3,6-Dichlorotrimellitic Anhydride 15883776, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Ying, Laiqiang; (22 pag.)US10513610; (2019); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

To a solution of the product from Step B (2 g) in ether (20 ml) at -78 C. was added t-BuLi dropwise. After stirring for 20 min, DMF (950 mg) was added dropwise and the mixture was stirred at ?25 C. for 3 hrs and then warmed to room temperature overnight. Saturated ammonium chloride was added and the solution was extracted with ether. The ether layer was washed with brine, dried with MgSO4, filtered and concentrated in vacuo to give 980 mg of crude product (67percent)., 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4687-25-6,Benzofuran-3-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Titanium tetrachloride (1.90 g, 10 mmol) was slowly added to100 mL of anhydrous THF at 0 ¡ãC, followed by addition of 5 mmol of the aldehyde (1) and stirred for 10 min, then ethyl 2-(3-bromopyridin-2-yl)acetate (2) (1.47 g, 6 mmol) was added. Subsequently, a solution of pyridine (3.16 g, 40 mmol) in 25 mL of anhydrous THF was added dropwise during a period of 30-60 min at 0 ¡ãC. The reaction mixture was then stirred for 1 h at room temperature and refluxed for 24 h. After that the mixture was poured on to crashed ice and extracted with ethyl acetate (4 30 mL). The combined extracts were successively washed with brine, saturated sodium hydrogen carbonate and brine, and then dried over anhydrous MgSO4. The organic phase was filtrated and the solvent was removed in vacuo, the residue was purified by column chromatography (silica gel) using PE/EA (5:1) / DCM/MeOH (50:1) to provide 3.

4687-25-6, As the paragraph descriping shows that 4687-25-6 is playing an increasingly important role.

Reference£º
Article; Li, Bo; Yue, Zhi-Zhou; Feng, Jian-Ming; He, Qian; Miao, Ze-Hong; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 531 – 539;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem