With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55745-70-5,2,3-Dihydrobenzo[b]furan-5-carbaldehyde,as a common compound, the synthetic route is as follows.
(a) 7-bromo-2,3-dihydro-l-benzofuran-5-carbaldehydeTo a solution of 2,3-dihydro-l-benzofuran-5-carbaldehyde (1.0 g, 6.75mmol) in glacial aGetic acid (8 ml) was added sodium acetate (664mg, 8.1mmol) and bromine (0.7ml, 13.5mmol) at 10C slowly. The reaction was stirred for 2h at room temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 ml), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%). MS (+ve ion electrospray): m/z 227 (M+H)+.
55745-70-5, 55745-70-5 2,3-Dihydrobenzo[b]furan-5-carbaldehyde 735901, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/71936; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem