With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196799-45-8,2,3-Dihydrobenzofuran-7-carbaldehyde,as a common compound, the synthetic route is as follows.,196799-45-8
(R)-2-(9-(pyridin-2-yl)-6-dioxaspiro[4.5]decane-9-yl)ethylamine (Intermediate 1)(0.260 g, 1.0 mmol) was dissolved in dichloromethane (10 mL)Further sodium sulfate (0.71 g, 5.0 mmol)And 2,3-dihydrobenzofuran-7-formaldehyde (74B) (0.18 g, 1.2 mmol)The reaction was added and the reaction was continued overnight at room temperature. Sodium borohydride (0.06 g, 1.2 mmol)After the reaction was added, the reaction was stirred for 10 minutes, and then methanol (10 mL) was added.The reaction was stirred for 1 hour. The reaction was quenched with water and the aqueous phase was treated with dichloromethane.Extraction of the alkane (20 mL ¡Á 3), combining the organic phases,Wash with saturated sodium chloride solution (30 mL), dry over anhydrous sodium sulfate and filtered. After the filtrate is concentrated, the crude product is purified by column chromatography (dichloromethane/methanol (v/v) = 50:1 to 20:1) to give a yellow oily liquid.(R)-N-((2,3-dihydrobenzofuran-7-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decane- 9-yl)ethylamine (74C)(0.18 g, yield: 45.9%).
196799-45-8 2,3-Dihydrobenzofuran-7-carbaldehyde 2795018, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Zhu Fengfei; Chen Qingping; Wang Chengtao; (251 pag.)CN109206417; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem