Simple exploration of 496-41-3

496-41-3, The synthetic route of 496-41-3 has been constantly updated, and we look forward to future research findings.

496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-(2-Furyl)-5,5-dimethyl-4-oxo-4,5-dihydro-3-furancarbonitrile (3a). To a stirred solutionoffuran-2-carboxylic acid (1a) (112 mg,1 mmol) and 4-hydroxy-4-methyl-2-pentynenitrile (2a) (135 mg,1.2 mmol) in MeCN (5 mL), Et3N (101 mg,1 mmol) was added dropwise over 1 min. The reaction mixture was irradiated with microwave at 100 C at 1.2 atm for 2 h (or was stirred at 100 C for 5 h). The residue was concentrated and washed with a mixture of C5H12-(CH3)2CO, 5:1 and 3:1, and then recrystallized with (CH3)2CO to give the desired product 3a as colorless crystals (172 mg, 85% or163 mg, 80% at 100C);

496-41-3, The synthetic route of 496-41-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Trofimov, Boris A.; Stepanov, Anton V.; Malkina, Anastasiya G.; Volostnykh, Olga G.; Shemyakina, Olesya A.; Ushakov, Igor A.; Synthetic Communications; vol. 45; 23; (2015); p. 2718 – 2729;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem