Some tips on 209256-42-8

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.,209256-42-8

To a solution of 2,3-dihydrobenzofuran-4-aldehyde (1g, 6.7 mmol) (Example 2, Part C) and dimethyl malonate 0.89 g, 6.7 mmol) in benzene (30 mL) was added piperidine (0.11 g, 1.4 mmol) and acetic acid (0.40 g, 6.7 mmol). The resulting solution was stirred for 18 hr with continuous removal of water. The solution was cooled to ambient temperature and concentrated. The residues was chromatographed on silica gel (ethyl acetat:hexane, 3:7) to give the title compound (1.5g).

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP1041980; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 13099-95-1

The synthetic route of 13099-95-1 has been constantly updated, and we look forward to future research findings.

13099-95-1, Ethyl 3-oxo-2,3-dihydrobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 10-mL glass tube equipped with a stirring bar was charged with benzofuranone 1 (0.60 mmol, 1.5 equiv), nitroallylic acetate 2 (0.40 mmol, 1 equiv), the catalyst K (0.04 mmol, 10 mol %), and CH2Cl2 (4.0 mL). The resulting solution was stirred at rt for 12 h. The solvent was evaporated under reduced pressure and the crude product was directly purified by flash column chromatography (PE/EtOAc from 20:1 to15:1) to provide the desired products 3., 13099-95-1

The synthetic route of 13099-95-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Long; Raabe, Gerhard; Enders, Dieter; Synthesis; vol. 51; 6; (2019); p. 1391 – 1398;,
Benzofuran – Wikipedia
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Some tips on 166599-84-4

166599-84-4, The synthetic route of 166599-84-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166599-84-4,Benzofuran-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of benzofuran-4-carboxylic acid (11 mg), PyBOP (35 mg), DIEA (0.030 mL) in dry DMF (0.15 mL), was added a solution of (2RS)-(2-aminomethyl-azetidin-1-yl)45-(4-fluoro-phenyl)-2-methyl-thiazol-4-A-methanone (20 mg) in dry DMF (0.1 mL). The resulting reaction mixture was stirred at RT for 20 h. The reaction mixture was diluted with EA, washed with water. The aqueous phase was extracted once again with EA, the combined organic extracts were dried (MgSO4), filtered and concentrated to yield a crude light brown oil.FC (EA to DCM/MeOH: 98/2) gave 23 mg (78%) of the title compound as a white solid.LC-MS: rt=0.94 min, 450 [M+H]+.

166599-84-4, The synthetic route of 166599-84-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Actelion Pharmaceuticals Ltd.; US2010/222600; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 115010-11-2

115010-11-2, As the paragraph descriping shows that 115010-11-2 is playing an increasingly important role.

115010-11-2, 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 1; N-[7-(4-piperidinyl)oxy-1-benzofuran-5-yl]-2-methoxy-5-methylbenzenesulfonamide; Example 1 was prepared as follows: 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide is produced starting from 2,3-dihydrobensofuran. Treatment with chlorosulfonic acid gives the corresponding sulfonyl chloride, which is iodinated using iodine monochloride. Aromatization is done using NBS, resulting in 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide after treatment with cresidine. Hydrolysis of 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide in alkaline solution using copper as catalyst results in 7-hydroxy-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide. Reaction with a methyl carbamate protected mesylate of 4-hydroxypiperidine, results in methyl 4-[(5-{[(2-methoxy-5-methylphenyl)amino]sulfonyl}-1-benzofuran-7-yl)oxy]piperidine-1-carboxylate, which is hydrolysed in alkaline solution giving the title compound.

115010-11-2, As the paragraph descriping shows that 115010-11-2 is playing an increasingly important role.

Reference£º
Patent; Caldirola, Patrizia; Johansson, Gary; Sutin, Lori; US2006/293361; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 54008-77-4

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

54008-77-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 13391-28-1

13391-28-1, 13391-28-1 5-Methoxybenzofuran 25943, abenzofuran compound, is more and more widely used in various fields.

13391-28-1, 5-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 15 Benzofuran-5-ol To a mixture of 5-methoxybenzofuran (10.0 g, 67.5 mmol) and tetrabutylammonium iodide (31.2 g, 84.4 mmol) in CH2Cl2 (100 mL) at -78 C. was added BCl3 (169 mL of a 1 M solution in CH2Cl2, 169 mmol) dropwise over 1 h. The reaction mixture was stirred for 1 h, warmed to rt, stirred for 14 h, poured slowly into sat. NaHCO3 and ice, and extracted with CH2Cl2 (2*). The combined extracts were dried (MgSO4), filtered, concentrated, and chromatographed (20% EtOAc in hexanes) to provide 9.16 g of benzofuran-5-ol as an orange solid. 1H NMR (400 MHz, CDCl3): delta 7.57 (d, 1, J=2.1), 7.34 (d, 1, J=8.7), 7.03 (d, 1, J=2.7), 6.84 (dd, 1, J=8.8, 2.6), 6.64 (dd, 1, J=2.2, 0.9), 6.20 (s, 1). Previously synthesised but data are not provided. Rene, L.; Royer, R. Bull. Soc. Chim. France, 1973, 7-8 (Pt. 2), 2355-6. The TBAl/BCl3 procedural reference is Brooks, P. R.; Wirtz, M. C.; Vetelino, M. G.; Rescek, D. M.; Woodworth, G. F.; Morgan, B. P.; Coe, J. W. J. Org. Chem. 1999, 64, 9719-9721.

13391-28-1, 13391-28-1 5-Methoxybenzofuran 25943, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc; US2006/58361; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 19477-73-7

19477-73-7 6-Bromoisobenzofuran-1(3H)-one 262235, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19477-73-7,6-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

6-Bromo-phthalide (2.30g, 10.9mmol) was added to a solution of N-bromosuccinimide (2.1g, 11.8mmol), azobisisobutyronitrile (0.1g, 0.06mmol) in 1,2-dichloroethane (60mL). The mixture was heated to reflux for 2hrs, cooled to room temperature, and concentrated under reduced pressure. The residue was washed with water (10mL*3) to give compound 50-f. The product was used directly for the next step without further purification., 19477-73-7

19477-73-7 6-Bromoisobenzofuran-1(3H)-one 262235, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WU, Tianzhi; (104 pag.)EP3275867; (2018); A1;,
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Benzofuran | C8H6O – PubChem

Simple exploration of 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

18761-31-4, 5-Nitrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 101 ; 2, 3-Dihvdro-benzofuran-5-vlamine; The product of preparation 100 (5. 0g, 31mmol) and 10percent Pd/C (1.25g) was added to ethanol (100mL) and the mixture was stirred under 55psi of hydrogen gas for 5 hours. The reaction mixture was then filtered through Celite and the filtrate was concentrated in vacuo to afford the title product as a pale brown powder in 92percent yield. MS ES+ m/z 135 [M+]. m. p. 73-77¡ãC, 18761-31-4

As the paragraph descriping shows that 18761-31-4 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 230642-84-9

230642-84-9 4-Vinyl-2,3-dihydrobenzofuran 11446416, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.230642-84-9,4-Vinyl-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

NMO (36.8 g, 314.6 mmol, 2.3 equiv), catalyst 1 (4 g, 5.5 mmol, 4 mol %) were suspended in dry dichloromethane (190 mL) under nitrogen atmosphere. Olefin 2 (20 g, 136.8 mmol, 1.0 equiv) were added and the mixture was stirred for approximately 15 min at ambient temperature, then it was cooled to approximately -70 C. M-CPBA (85 %, 44.5 g, 218.9 mmol, 1.6 equiv) in absolute ethanol (150 mL) was added dropwise and stirred at -60 to -70 C for 5 h. A 1 mol/L aqueous NaOH solution (approximately 300 mL) was added to maintain pH = 9 and the mixture was extracted with dichloromethane. The combined organic phase was washed with brine, then dried (Na2SO4). The organic phase was concentrated under reduced pressure to obtain a black oil. The residue was purified by flash column chromatography on silica gel, affording a light yellow oil 3 (17 g, yield 78 %)., 230642-84-9

230642-84-9 4-Vinyl-2,3-dihydrobenzofuran 11446416, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Li, Xi-An; Yue, Lirong; Zhu, Jianrong; Ren, Huazhong; Zhang, Hong; Hu, Dong-yan; Han, Guangtian; Feng; Nan, Ze-dong; Tetrahedron Letters; vol. 60; 30; (2019); p. 1986 – 1988;,
Benzofuran – Wikipedia
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Simple exploration of 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 15, 9k or 9m (190 mmol) and CuCN (49.00 g, 570 mmol) in DMF (500 mL) werestirred at 130 ¡ãC (for 15 and 9m) or reflux (for 9k) in N2 atmosphere for 12 h, when TLC analysisindicated completion of reaction. On cooling to room temperature, the reaction mixture was dilutedwith CH2Cl2 (1000 mL), and the resulting mixture was further stirred for 1 h and filtered off. Thefiltrate was washed with 5percent brine (500 mL ¡Á 5), dried (Na2SO4) and evaporated on a rotaryevaporator, which was purified by column chromatography to afford 16, 10k or 10m., 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Cai, Wenqing; Wu, Jingwei; Liu, Wei; Xie, Yafei; Liu, Yuqiang; Zhang, Shuo; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 23; 2; (2018);,
Benzofuran – Wikipedia
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