With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19477-73-7,6-Bromoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.
6-Bromo-phthalide (2.30g, 10.9mmol) was added to a solution of N-bromosuccinimide (2.1g, 11.8mmol), azobisisobutyronitrile (0.1g, 0.06mmol) in 1,2-dichloroethane (60mL). The mixture was heated to reflux for 2hrs, cooled to room temperature, and concentrated under reduced pressure. The residue was washed with water (10mL*3) to give compound 50-f. The product was used directly for the next step without further purification., 19477-73-7
19477-73-7 6-Bromoisobenzofuran-1(3H)-one 262235, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WU, Tianzhi; (104 pag.)EP3275867; (2018); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem