With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.230642-84-9,4-Vinyl-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.
NMO (36.8 g, 314.6 mmol, 2.3 equiv), catalyst 1 (4 g, 5.5 mmol, 4 mol %) were suspended in dry dichloromethane (190 mL) under nitrogen atmosphere. Olefin 2 (20 g, 136.8 mmol, 1.0 equiv) were added and the mixture was stirred for approximately 15 min at ambient temperature, then it was cooled to approximately -70 C. M-CPBA (85 %, 44.5 g, 218.9 mmol, 1.6 equiv) in absolute ethanol (150 mL) was added dropwise and stirred at -60 to -70 C for 5 h. A 1 mol/L aqueous NaOH solution (approximately 300 mL) was added to maintain pH = 9 and the mixture was extracted with dichloromethane. The combined organic phase was washed with brine, then dried (Na2SO4). The organic phase was concentrated under reduced pressure to obtain a black oil. The residue was purified by flash column chromatography on silica gel, affording a light yellow oil 3 (17 g, yield 78 %)., 230642-84-9
230642-84-9 4-Vinyl-2,3-dihydrobenzofuran 11446416, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Article; Li, Xi-An; Yue, Lirong; Zhu, Jianrong; Ren, Huazhong; Zhang, Hong; Hu, Dong-yan; Han, Guangtian; Feng; Nan, Ze-dong; Tetrahedron Letters; vol. 60; 30; (2019); p. 1986 – 1988;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem