64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: 5-ethenyl-2-benzofuran-1(3H)-one: 5-Bromophthalide (50g, 235 mmol), potassium vinyltrifluoroborate (62.9 g, 469 mmol), and PdCl2(dppf)-CH2Cl2 Adduct (9.58 g, 11.7 mmol) wereadded to ethanol (500 mL) then TEA (65.4 mL, 469 mmol) was added. The reaction mixture wasdegassed then heated at reflux for 8 h. The reaction was worked up by diluting with ethyl acetate and washing with brine twice. The organic layer was dried and evaporated to dryness. The crudeproduct was purified by MPLC (silica, 600g column) with 25% EtOAc/hexane (3 L) then with30% EtOAc/Hexane (2 L) to yield the title compound.
64169-34-2, The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem