Tag: M.W:200-300

81742-10-1, 3,6-Dichlorotrimellitic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

81742-10-1, 4-(naphth-2-yl)-2-fluoro-1,3-dihydroxybenzene 14 (760 mg, 2.988 mmol) obtained from Example 3, anhydrous 2,5-dichlorotrimellitic acid 23 (780 mg, 2.988 mmol, PE Applied Biosystems, Foster City, CA (AB) Part No. 361892), nitrobenzene (5 mL), and aluminum chloride in nitrobenzene (15 mL, 1 M, Aldrich Chemical) were mixed and the mixture was stirred at room temperature for 16 hours. The reaction mixture was added to ice water (100 mL) and was poured into a magnetically stirred mixture of ethyl acetate (100 mL), 10% HCl (100 mL) was added, and aluminum salt was dissolved. The organic layer was washed with water (100 mL ¡Á 2) and washed with brine (100 mL ¡Á 1), dried over sodium sulfate, filtered, and the solvent was removed. The product was obtained as an isomeric mixture. The product was purified by silica gel column chromatography (silica gel,10% methanol in dichloromethane mobile phase) to obtain the desired slow moving isomer 340 mg (22%) .

The synthetic route of 81742-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
Benzofuran – Wikipedia
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81742-10-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81742-10-1,3,6-Dichlorotrimellitic Anhydride,as a common compound, the synthetic route is as follows.

4-(naphth-2-yl)-2-fluoro-1,3-dihydroxybenzene 14 (100 mg, 0.4 mmol) obtained from Example 3, anhydrous 2,5-dichlorotrimellitic acid 23 (52 mg, 0.2 mmol, AB part 361892), and methanesulfonic acid (5 mL) at 120-130C, and the mixture was stirred for 2 hours. Then,the mixture was mixed with ice water (50 mL), cooled and precipitate was formed. The precipitated dye was extracted with ethyl acetate (100 mL), the extract was washed with water (50 mL ¡Á 2) and washed with brine (50 mL ¡Á 1). The resulting mixture was dried over sodium sulfate, filtered, and solvent was removed and the crude pigment was obtained as two isomers. The obtained isomers can be separated by thin-layer chromatography (silica gel,Mobile phase of dichloromethane: methanol: acetic acid 100: 10: 2 (by volume)), and 60 mg (41%) of the desired slowly moving isomer was obtained.

81742-10-1 3,6-Dichlorotrimellitic Anhydride 15883776, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; APPLIED BIOSYSTEMS Ltd. LIABILITY COMPANY; BENSON, SCOTT CONRAD; MENCHEN, STEVEN MICHAEL; THEISEN, PETER DAVID; UPADHYA, KRISHNA GAJANAN; HAUSER, JOAN DALE; (37 pag.)JP2015/57478; (2015); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Compound 177 (2.0 g, 9.66 mmol) and beta-alanine methylester?HC1 (1.752 g, 12.55 mmol) were dissolved in DMF (48.3 mL). EDC (2.41 g, 12.55 mmol) and DMAP (0.59 g, 4.83 mmol) were added and the reaction was stirred under Ar at rt for 2 d. An additional amount of beta-alanine methylester?HC1 (337 mg), EDC (462 mg), and DMAP (147 mg) were added and stirred for an additional night. The reaction was cooled in an ice bath and then water was added to precipitate the desired compound. The solution was filtered to obtain compound 181 (2.82 g, 100% yield), which used without further purification. LCMS = 4.33 mm (8 mm method). Mass observed (ESI): 293.0 (M+H). ?H NMR (400 MHz, CDC13): 2.70 (t, J= 5.8 Hz, 2H), 3.75 (s, 3H), 3.76 – 3.81 (m, 2H), 7.30 (s, 1H), 7.59 (s, 1H), 7.63 (d, J = 9.1 Hz, 1H), 8.34 (dd, J= 9.1, 2.3 Hz, 1H), 8.62 (d, J= 2.3 Hz, 1H)., 10242-12-3

The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzofuran – Wikipedia
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6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6296-53-3

Example 13 N-{2-[1-(3-Cyclopropylmethoxy-4-methoxy-phenyl)2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide To a solution of i-(3-cyclopropylmethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine (1.0 g, 3.3 mmol) in acetic acid (10 mL), was added 3acetamido-phthalic anhydride (1.37 g, 6.7 mmol) and sodium acetate (0.54 g, 6.7 mmol). The mixture was heated at reflux temperature overnight. The solvent was removed in vacuo. The resulted oil was extracted with ethyl acetate (50 mL) and water (30 mL). The organic layer was washed with water (30 mL*2) and brine (30 mL) and dried over magnesium sulfate. The solvent was removed in vacuo and the resulted oil was purified by silica gel column to give N-{2-[1-(3-cyclopropylmethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide as a white solid (340 mg, 21percent): mp 102-104¡ã C.; 1H-NMR (CDCl3) delta 0.35-0.37 (m, 2H, c-CH2), 0.62-0.67 (m, 2H, c-CH2), 0.88-0.93 (m, 2H, c-CH2), 1.25-1.32 (m, 1H, c-CH), 2.25 (s, 3H, CH3), 2.87 (s, 3H,CH3), 3.75 (dd, J=4, 15 Hz, 1H, CHH), 3.83-3.85 (m, 5H, OCH2+OCH3), 4.53 (dd, J=10, 15 Hz, 1H, CH2), 5.85 (dd, J=4, 10 Hz, 1H, NCH), 6.84 (d, J=8 Hz, 1H, Ar), 7.07-7.10 (m, 2H, Ar), 7.45 (d, J=5 Hz, 1H, Ar), 7.62 (t, J=8 Hz, 1H, Ar), 8.72 (d, J=8 Hz, 1H, Ar), 9.45 (s, 1H, NHCO); 13C NMR (CDCl3) delta 1.6, 3.2, 3.3, 24.7, 41.4, 48.3, 54.2, 55.8, 73.9, 111.5, 113.1, 115.0, 118.0, 120.3, 124.7, 129.1, 130.9, 135.9, 137.2, 148.6, 149.8, 167.2, 169.0, 169.3. Analy. Calculated for C24H26N2O7S: C, 59.25; H, 5.39; N, 5.76. Found: C, 59.00; H, 5.36; N, 5.55.

The synthetic route of 6296-53-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Muller, George W.; Man, Hon-Wah; US2006/84815; (2006); A1;,
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Benzofuran | C8H6O – PubChem

143878-29-9, Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

25 g of intermediate (IV) was added to 140 mL of water and 27 mL of propylene glycol monomethyl ether, stirred,Add 20mL 50% sodium hydroxide solution, the system temperature to 90-100 , stirring temperature 12h,Stirring speed 300r / min, cooling to 0-10 , stirring 1h, filtered to obtain solid (intermediate sodium salt).The sodium salt of intermediate V was added to 200 mL of water and 40 mL of propylene glycol monomethyl ether and the temperature was raised to 75-85 C,Dropping 10mL concentrated hydrochloric acid, pH 1-2, precipitation of solid, cooling to 0-10 , stirring 1h,Stirring speed 300r / min, suction filtration, washing, drying at 50-60 for 8h to obtain intermediates (V)White solid, 13.2 g, yield 66%, purity 100.0% (HPLC)., 143878-29-9

143878-29-9 Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate 10635698, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Fuxin Fengcheng Chemical Technology Development Co., Ltd; Wang, Ji; Cao, Ronghao; (7 pag.)CN106316998; (2017); A;,
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Benzofuran | C8H6O – PubChem

143878-29-9, Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting intermediate 7 (30 g, 0.11 mol), water (150 mL),Propylene glycol monomethyl ether (36mL) and 50% sodium hydroxide solution (90mL), slowly heated to 90 C with stirring, the same temperature for 8h, the reaction was monitored by TLC. After the reaction is completed,Cooled to 5 C with ice bath and stirred for 2h, filtered with suction,The filter cake was washed with an appropriate amount of water added to 500mL single-necked flask,Water (210 mL) and propylene glycol monomethyl ether (35 mL) were added,The temperature of the reaction solution was raised to 80 C and the reaction solution became homogeneous.Dilute dilute hydrochloric acid, adjust pH to about 3, precipitated solid.After cooling to 10 C, stirring was continued for 2h. Suction filtration,The filter cake was washed with an appropriate amount of water and dried to give an off-white solid,Yield 20.8g, yield 89.8%, purity 99%, 143878-29-9

The synthetic route of 143878-29-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenyang Pharmaceutical University; Wang Shaojie; Lei Yu; Bao Li; (9 pag.)CN107337658; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32703-79-0,5-(tert-Butyl)isobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

General procedure: A reaction vessel was charged with phthalic anhydride (1.0 mmol), alkyl acrylate (2.0 mmol), ruthenium catalyst (0.015 mmol, 9mg), Cu(OAc)2*H2O (400 mg, 2.0 mmol), and NMP (3ml) in air. The reaction vessel was then sealed and stirred at 120 C for 20 h. Then, the mixture was cooled to room temperature and diluted with ethyl acetate and washed with brine. The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. The resulting residue that was purified by column chromatography using ethyl acetate-hexane (15:85) as the solvent, and then recrystallized in ethyl acetate-hexane (15:85).

32703-79-0, As the paragraph descriping shows that 32703-79-0 is playing an increasingly important role.

Reference£º
Article; Kianmehr, Ebrahim; Fardpour, Maryam; Darvish, Ali; Kharat, Ali Nemati; Weng Ng, Seik; Tetrahedron Letters; vol. 60; 10; (2019); p. 699 – 702;,
Benzofuran – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115010-11-2,2,3-Dihydro-1-benzofuran-5-sulfonoylchloride,as a common compound, the synthetic route is as follows.

Take compound IX-2 (300mg, 1.37mmol) in chlorobenzene (2mL),Add N-bromosuccinimide (244 mg, 1.37 mmol),Azobisisobutyronitrile (3mg),The temperature was raised to 80 C.After heating for 1.5 hours,Add N-bromosuccinimide (122 mg, 0.685 mmol),The reaction was monitored by TLC after 4 hours.After the reaction was cooled to room temperature, water (5 mL) was added.Ethyl acetate extraction (3mL x 3),Combined organic phases,Washed with saturated saline (3mL x 2),Dry over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure,The residue was purified by column chromatography (petroleum ether / ethyl acetate = 50/1) to obtain compound XI-1 (yellow oil, 337 mg).

115010-11-2, 115010-11-2 2,3-Dihydro-1-benzofuran-5-sulfonoylchloride 2776154, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; China Pharmaceutical University; Sun Hongbin; Yan Dingfei; Feng Zhiqi; Zhang Jia; Yao Zhiying; Zhao Wenfeng; Zhang Xiangying; Sun Geng; Han Lishuai; Wu Wenzhen; Liu Shengjie; Zhao Xing; Li Minglei; Yu Shengqi; Chen Hui; Cheng Yalong; Wang Pengfei; Dai Liang; Wen Xiaoan; Liu Jun; (102 pag.)CN110372638; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

174775-48-5, Ethyl 5-aminobenzofuran-2-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Commercially available ethyl 5-NITROBENZOFURAN-2-CARBOXYLATE 30 was HYDROGENATED on PD-C and ACYLATED using commercially available 4-NITRO-N-METHYL-2- TRICHLOROACETYL-PYRROLE 32 to form 33. HYDROGENATION of 33 followed by acylation with 32 afforded the nitro compound 35, which upon HYDROGENATION yielded 36 as the amino compound. ACETYLATION of the amino group of 36 followed by base catalyzed hydrolysis resulted in the acid 37. Coupling of 37 with the hydrochloride salt 39 (obtained by DEPROTECTION of the BOC derivative 38) using EDC afforded the ester 40. See Figure 4., 174775-48-5

As the paragraph descriping shows that 174775-48-5 is playing an increasingly important role.

Reference£º
Patent; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; WO2005/32594; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-11-2,5-Bromobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Shikonin (1mmol), benzofuran-2-carboxylic acid derivatives (4a-4q) (3mmol), 4-dimethyaminopyridine (0.5mmol), and N, N?- dicyclohexylcarbodiimide (0.5mmol) were suspended in the anhydrous DCM (10ml). The reaction mixture was stirred for 8h under 0C. Afterwards, the targeted compounds 6a-6q were purified by column chromatography., 10242-11-2

The synthetic route of 10242-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kong, Ling-Yi; Leng, Jia-Fu; Lian, Bao-Ping; Shao, Yu-Ying; Xia, Yuan-Zheng; Yin, Yong; European Journal of Medicinal Chemistry; vol. 190; (2020);,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem