With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10242-12-3,5-Nitrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Compound 177 (2.0 g, 9.66 mmol) and beta-alanine methylester?HC1 (1.752 g, 12.55 mmol) were dissolved in DMF (48.3 mL). EDC (2.41 g, 12.55 mmol) and DMAP (0.59 g, 4.83 mmol) were added and the reaction was stirred under Ar at rt for 2 d. An additional amount of beta-alanine methylester?HC1 (337 mg), EDC (462 mg), and DMAP (147 mg) were added and stirred for an additional night. The reaction was cooled in an ice bath and then water was added to precipitate the desired compound. The solution was filtered to obtain compound 181 (2.82 g, 100% yield), which used without further purification. LCMS = 4.33 mm (8 mm method). Mass observed (ESI): 293.0 (M+H). ?H NMR (400 MHz, CDC13): 2.70 (t, J= 5.8 Hz, 2H), 3.75 (s, 3H), 3.76 – 3.81 (m, 2H), 7.30 (s, 1H), 7.59 (s, 1H), 7.63 (d, J = 9.1 Hz, 1H), 8.34 (dd, J= 9.1, 2.3 Hz, 1H), 8.62 (d, J= 2.3 Hz, 1H)., 10242-12-3
The synthetic route of 10242-12-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem