Tag: M.W:200-300

286836-04-2, 5-Bromo-7-fluorobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 28 (5-bromo-7-fluorobenzofuran, was added to the reaction vessel.5.0 g, 23.2 mmol), compound 13 (4,4,5,5-tetramethyl-2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-1,3, 2-dioxaborolan,6.4 g, 21.0 mmol), toluene (64.0 mL, 10 mL/g),Methanol (6.4 mL, 1 mL/g).After adding Cs2CO3 (13.7 g, 42.0 mmol),Pd(PPh3)4 (1.2 g, 1.1 mmol) was added under a nitrogen atmosphere.The reaction was carried out by refluxing at 120 C for 3 hours.After the reaction, the reaction is cooled to normal temperature.And filtered with celite using ethyl acetate.The filtered solution is washed with brine.It was then dried over anhydrous sodium sulfate and filtered and evaporated.The concentrate was subjected to silica gel column chromatography (hexane:EtOAc = 7:1)Purification to give a white solid compound 29(5.2 g, yield 71.6%)., 286836-04-2

As the paragraph descriping shows that 286836-04-2 is playing an increasingly important role.

Reference£º
Patent; Dongjin Shimeiken Co., Ltd.; Cui Zhenyu; Jiang Bingnan; Yin Xingyi; Song Zhenyin; Jin Xingxie; Li Dongxuan; Cui Zhien; Li Xuanzhi; Shen Guichun; (45 pag.)CN109206387; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143878-29-9,Methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate,as a common compound, the synthetic route is as follows.

Crude methyl 4-acetylamino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylate (125 g), obtained in the above step-3, and methanol (531.6 ml) were taken into a reaction flask at 25-30C and the contents were stirred for 10 minutes at the same temperature. To the resulting mass, a mixture of sodium hydroxide (15.8 g) and water (98 ml) was added at 25- 30C, followed by stirring the mixture for 10 minutes at the same temperature. The resulting mass was heated to 50-55C and then stirred for 2 hours at the same temperature. The resulting solution was cooled to 0-5C and then stirred for 1 hour at the same temperature. The separated solid was filtered and washed with chilled methanol (50 ml) to produce 30 g of 4-acetylamino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid sodium salt (Purity by HPLC: 98.2%)., 143878-29-9

The synthetic route of 143878-29-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYMED LABS LIMITED; MOHAN RAO, Dodda; VENUGOPAL, Bingi; (46 pag.)WO2017/137910; (2017); A1;,
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Benzofuran | C8H6O – PubChem

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

28418-88-4, SYNTHESIS EXAMPLE 7-1 To a solution of 3-iodophthalic anhydride (32.5 g) in dimethylformamide (300 mL), a solution of (2S)-1-(methylthio)propan-2-amine (15.0 g) in dimethylformamide (50 mL) was added dropwise at -10 C. for 3 hours, and the mixture was stirred at -10 C. for additional 3 hours. After addition of 40% sodium hydroxide aqueous solution (15 g), the solvent was distilled off under reduced pressure, and the crude product was dissolved in water (500 mL) and washed with diisopropyl ether. The water phase was separated, adjusted to pH 1 with concentrated hydrochloric acid and extracted with diisopropyl ether. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off, and the resulting crude crystal was washed with a small amount of diisopropyl ether and air-dried to obtain 3-iodo-2-{[(1S)-1-methyl-2-(methylthio)ethyl]-carbamoyl}benzoic acid (32.2 g). Melting point: 132-134 C.

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer CropScience AG; US2011/184188; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Example 15:Preparation of (S)-2,2-diphenyl-2-{l-[2-(2,3-dihydrobenzofuran-5yl)-ethyl]- pyrrolidin-3yl} acetic acid methyl ester: A mixture of 3-(S)-2,2-diphenyl-2-pyrrolidinyl-3yl-acetic acid methyl ester(29.5 grams), 5-(2-bromoethyl)2,3-dihydrobenzo[2,3-b]furan (22.7 grams), anhydrous potassium carbonate (27.6 grams) and acetonitrile (300 ml) was heated to reflux and stirred for 60 min. The mixture was partitioned between methylene chloride (250 ml) and 10percent aqueous potassium carbonate (250 ml). The two layers were separated and the aqueous layer was extracted with methylene chloride. The organic layer was dried with sodium sulphate and distilled off the organic layer under reduced pressure followed by triturating with ethyl acetate to get the title compound. Yield: 30.5 grams

127264-14-6, As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

Reference£º
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
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28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Iodophthalic anhydride (598 mg, 2.18 mmol) was dissolved in DMF (14 mL), and the solution was added with an aqueous solution (10 mL) of hexamethyldisilazane (HMDS) (4.6 mL, 22 mmol) and methanol (0.44 mL, 11 mmol), followed by stirring at room temperature for 18.5 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressurea and the residue was purified by slurry using chloroform to obtain 3-iodophtalimide (403 mg, yield 68%). APCI-MS m/z: 272 [M-H]-; 1H-NMR (DMSO-d6)delta(ppm): 7.53 (dd, J = 7.4, 7.8 Hz, 1H), 7.84 (dd, J = 0.6, 7.3 Hz, 1H), 8.22 (dd, J = 0.6, 7.8 Hz, 1H), 11.52 (br s, 1H).

28418-88-4, As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
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Benzofuran | C8H6O – PubChem

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The bromo compound 3 (4.54 g, 0.02 mol) and 3-(R)-(1-carbamoyl-1,1-diphenylmethyl)-pyrrolidine (4, 5.6 g, 0.02 mol) were refluxed in acetonitrile containing KOH (1.12 g, 0.02 mol). The reaction mixture was distilled off, water (50 mL) and MDC (50 mL) was added to the obtained residue to form a two-phase mixture. The phases were separated and organic phase was distilled under vacuum. The obtained residue was dissolved in methyl ethyl ketone (10 mL) and filtered to eliminate un-dissolved solid. The 48percent HBr (0.344 g, 0.00204 mol) was added to the filtrate and distilled under vacuum to afford solid foam. The foam was scurried in diisopropylether and filtered to get the title compound in 7 g yield.

127264-14-6, 127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Vasantha; Lakshmanarao; Srinivasa Rao; Sivalakshmi Devi; Venkata Suryanarayana; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 52; 6; (2013); p. 824 – 828;,
Benzofuran – Wikipedia
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28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0592] To a solution of 4-iodoisobenzofuran-1,3-dione (2.97 g, 10.84 mmol) and (S)-3-aminoazepan-2-one (1.39 g, 10.84 mmol) in ACN (15 mL) and AcOH (21 mL) at rt. The suspension was heated to 80 C and stirred overnight. Cooled to rt, sodium acetate (2.22 g, 27.1 mmol) and AcOH (10 mL) were added. The reaction mixture was heated to 80 C and stirred overnight. TLC showed the starting material was consumed and a new spot was present. Upon removal of the solvent, the residue was diluted with water (8 mL) and stirred 30 minutes. The mixture was extracted with EA and concentrated providing (S)-4-iodo-2-(2- oxoazepan-3-yl)isoindoline-1,3-dione (2.4 g, 57.7% yield) as a white solid. MS (ESI) m/z = 385 [M+H]+., 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
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Benzofuran | C8H6O – PubChem

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

678.5 mg of material was dissolved in 8 ml of N,N-dimethylacetamide, then 0.172 g of potassium carbonate and 263 mg of 7-bromo-2-benzofuranone were added in turn. The mixture was reacted at 40-45 C. for 4 hours. At the end of the reaction, 30 ml of water was added. The resulting mixture was extracted twice with 25 ml of ethyl ether. The organic phase was dried and concentrated to give 606.4 mg of esterified intermediate with a yield of 75%. The intermediate was dissolved in 15 ml of dioxane and 4 ml of 4N HCl was added. The mixture was reacted at room temperature for 16 hours. The resulting solution was poured into water, extracted with ethyl acetate, dried, concentrated and flash chromatographed (eluent: ethyl acetate/petroleum ether=1/2) to give 284.7 mg of pure product (+/-)2-butyl-4-chloro-1-[2′-(1H-tetrazol-5-yl)1,1′-biphenyl-methyl]imidazole-5-carboxylic acid, 2[C]-benzofuranonyl ester with a yield of 67%.1H-NMR (DMSO-d6) delta H (ppm): 0.88 (t, 3H, J=21.6), 1.26 (m, 4H, J=29.6), 1.58 (m, 2H, J=30.5), 2.50 (t, 2H, J=15.5), 5.34 (s, 2H), 6.95-7.63 (12H), 8.06 (d, 2H, J=9.1)ESI (+) m/z: 569.5Mp: 120.6-124.6 C., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Guo, Jianhui; An, Dong; US2009/36505; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

(2) Preparation of 1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil STR26 In the same manner as in Example 3-(2), a mixture of the compound 11 provided in the above step (1) and 5-FU in dimethylsulfoxide is allowed to react in the presence of 1 equimolar amount of anhydrous potassium carbonate at room temperature to give the titled compound 3 in good yield.

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Patent; Shionogi & Co., Ltd.; US4605738; (1986); A;,
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Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromoisobenzofuran-1(3H)-one (10.00 g, 47.2 mmol),Benzyltriethylammonium chloride (2.20g, 9.4mmol), boron trifluoride diethyl ether (1.20mL, 9.40mmol), xylene (50mL) was added to the reaction flask, and the reaction solution was replaced with nitrogen three times and then heated to 110 C. Reaction for 30 min. Next, thionyl chloride (8.60 mL, 118.0 mmol) was slowly added dropwise to the above reaction solution, and the mixture was heated to 130 C for 6 hours, cooled to 40-50 C, and the reaction was quenched by dropwise addition of methanol (20 mL). The reaction solution is evaporated under reduced pressure to give a solvent.The title compound 1b (11.40 g, 93.0%) was obtained.

64169-34-2, As the paragraph descriping shows that 64169-34-2 is playing an increasingly important role.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem