Downstream synthetic route of 28418-88-4

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

(3-1). Production of 3-iodo-N-(4-heptafluoroisopropyl-2-methylphenyl)phthalimide To a suspension of 2.7 g of 3-iodophthalic anhydride in 30 ml of acetic acid was added 2.7 g of 4-heptafluoroisopropyl-2-methylaniline, and the resulting mixture was heated under reflux for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure from the reaction mixture, and the resulting residue was purified by silica gel column chromatography to obtain 4.8 g of the desired compound. Yield: 89%.

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Nihon Nohyaku Co., Ltd.; EP1241159; (2002); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 28418-88-4

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

To the beaker 1 was added 10.0 g of 1.1-dimethyl-2-methylthioethylamine (0.084 mol) and 15.6 g at 20-35 C.Acetone; 17.7 g of 3-iodophthalic anhydride (0.065 mol) and 70 g of acetone were added to beaker 2, and stirred with a glass rod for 5 minutes.After the clock, the solid is completely dissolved; in the beaker 1, the liquid A is pumped into the mixer by the mechanical pump A, and at the same time, the liquid B in the beaker 2 is also used by the mechanical pump B.Pumped into the mixer, the flow ratio of mechanical pump A to mechanical pump B is 1:3.43 (mass ratio), and the liquid in the mixer enters the operation.In a microchannel reactor with a temperature of 8 C, the retention time in the microchannel reactor was 10 minutes, and the cone was received and discharged.The reaction solution was evaporated under reduced pressure to give a pale yellow solid: 24.3 g, yield: 95.7% (3-iodophthalic anhydrideThe main product content is: 96% (HPLC), the isomer content is 2.6% (HPLC),, 28418-88-4

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Liu Zuhe; Yao Yuan; Lu Wenlong; Cao Li; (7 pag.)CN109574892; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 28418-88-4

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1; Preparation of 3-iodo-N,N-diethylphthalamidic acid . To 15 ml of an acetonitrile solution containing 2.0 g of 3-iodophthalic anhydride was added dropwise 0.7 g of diethylamine under ice-cooling and stirring, and after completion of the dropwise addition, the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the precipitated solid were collected by filtration, washed with a small amount of acetonitrile to obtain 1.5 g of the objective material as pale yellowish crystals. Melting point 120.0 to 122.0C1H NMR (CDCl3, Me4Si, 300MHz) delta 8.28 (bs, 1 H), 8.05 (d, J=8.5Hz, 1 H), 7.98 (d, J=8.5Hz, 1 H), 7.0-7.2 (m, 1 H), 3.67 (q, J=7.2Hz, 2H), 3.49 (q, J=7.2Hz, 2H), 1.12 (t, J=7.2Hz, 3H), 1.10 (t, J=7.2Hz, 3H).

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; NISSAN CHEMICAL INDUSTRIES, LIMITED; EP1538138; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 28418-88-4

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

28418-88-4, SYNTHESIS EXAMPLE 7-1 To a solution of 3-iodophthalic anhydride (32.5 g) in dimethylformamide (300 mL), a solution of (2S)-1-(methylthio)propan-2-amine (15.0 g) in dimethylformamide (50 mL) was added dropwise at -10 C. for 3 hours, and the mixture was stirred at -10 C. for additional 3 hours. After addition of 40% sodium hydroxide aqueous solution (15 g), the solvent was distilled off under reduced pressure, and the crude product was dissolved in water (500 mL) and washed with diisopropyl ether. The water phase was separated, adjusted to pH 1 with concentrated hydrochloric acid and extracted with diisopropyl ether. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off, and the resulting crude crystal was washed with a small amount of diisopropyl ether and air-dried to obtain 3-iodo-2-{[(1S)-1-methyl-2-(methylthio)ethyl]-carbamoyl}benzoic acid (32.2 g). Melting point: 132-134 C.

28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer CropScience AG; US2011/184188; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 28418-88-4

28418-88-4, As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Iodophthalic anhydride (598 mg, 2.18 mmol) was dissolved in DMF (14 mL), and the solution was added with an aqueous solution (10 mL) of hexamethyldisilazane (HMDS) (4.6 mL, 22 mmol) and methanol (0.44 mL, 11 mmol), followed by stirring at room temperature for 18.5 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressurea and the residue was purified by slurry using chloroform to obtain 3-iodophtalimide (403 mg, yield 68%). APCI-MS m/z: 272 [M-H]-; 1H-NMR (DMSO-d6)delta(ppm): 7.53 (dd, J = 7.4, 7.8 Hz, 1H), 7.84 (dd, J = 0.6, 7.3 Hz, 1H), 8.22 (dd, J = 0.6, 7.8 Hz, 1H), 11.52 (br s, 1H).

28418-88-4, As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0592] To a solution of 4-iodoisobenzofuran-1,3-dione (2.97 g, 10.84 mmol) and (S)-3-aminoazepan-2-one (1.39 g, 10.84 mmol) in ACN (15 mL) and AcOH (21 mL) at rt. The suspension was heated to 80 C and stirred overnight. Cooled to rt, sodium acetate (2.22 g, 27.1 mmol) and AcOH (10 mL) were added. The reaction mixture was heated to 80 C and stirred overnight. TLC showed the starting material was consumed and a new spot was present. Upon removal of the solvent, the residue was diluted with water (8 mL) and stirred 30 minutes. The mixture was extracted with EA and concentrated providing (S)-4-iodo-2-(2- oxoazepan-3-yl)isoindoline-1,3-dione (2.4 g, 57.7% yield) as a white solid. MS (ESI) m/z = 385 [M+H]+., 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 28418-88-4

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

(1-1) Production of N-(4-methyl-3-trifluoromethylisoxazol-5-yl)-3-iodophthalimide In 20 ml of acetic acid, 0.6 g of 3-iodophthalic anhydride and 0.44 g of 5-amino-4-methyl-3-trifluoromethyl-isoxazole were dissolved and reacted for 9 hours with heating under reflux. After completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was dissolved in ethyl acetate, washed with dilute hydrochloric acid, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, and then dried on sodium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography using a 3/1 mixture of hexane and ethyl acetate as an eluent to obtain 0.71 g of the objective product. Property: m.p. 105C; Yield: 69%

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Nihon Nohyaku Co., Ltd.; EP1193254; (2002); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 28418-88-4

The synthetic route of 28418-88-4 has been constantly updated, and we look forward to future research findings.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,28418-88-4

A solution of 3.5 g of 4-heptafluoro-isopropyl-2-methylaniline in 3 ml of acetonitrile was slowly dropped into a suspension of 3.5 g of 1-iodophthalic anhydride in 30 ml of acetonitrile under ice-cooling. After completion of the dropwise addition, the reaction was carried out with stirring at room temperature for 3 hours. After completion of the reaction, the crystals precipitated were collected by filtration and washed with a small volume of acetonitrile to obtain 4.0 g of the desired compound. [0086] Physical property: m.p. 174-181 C. Yield: 57%.

The synthetic route of 28418-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tohnishi, Masanori; Kohno, Eiji; Nakao, Hayami; Nishida, Tateki; Furuya, Takashi; Shimizu, Toshiaki; Seo, Akira; Sakata, Kazuyuki; Fujioka, Shinsuke; US2004/9982; (2004); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 28418-88-4

The synthetic route of 28418-88-4 has been constantly updated, and we look forward to future research findings.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.19 g of 1,1-dimethyl-2-methylthioethylamine compound of formula III was dissolved in 10 ml of acetonitrile.Under ice bath, it was added dropwise to a solution of 2.74 g of 3-iodophthalic anhydride compound of formula II and 10 ml of acetonitrile.Reacting at room temperature for 3 hours,The acetonitrile was distilled off under reduced pressure, and then 30 ml of toluene was added to the reaction flask to dissolve the residue.Then added dropwise to 3.15 g of trifluoroacetic anhydride,React at room temperature for 1 hour,After distilling off toluene under reduced pressure,A yellow oily liquid is obtained as a compound of formula IV.

The synthetic route of 28418-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; East China University of Science and Technology; Cao Song; Zhao Xianghu; He Jingjing; Li Jialu; Liu Yisen; Li Chunmei; Xu Sixue; Huang Qingchun; (19 pag.)CN110272361; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem