With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
SYNTHESIS EXAMPLE 7-1;To a solution of 3-iodophthalic anhydride (32.5 g) in dimethylformamide (300 mL), a solution of (2S)-I- (methylthio)propan-2-amine (15.0 g) in dimethylformamide (50 mL) was added dropwise at -100C for 3 hours, and the mixture was stirred at -100C for additional 3 hours. After addition of 40% sodium hydroxide aqueous solution (15 g), the solvent was distilled off under reduced pressure, and the crude product was dissolved in water (500 mL) and washed with diisopropyl ether. The water phase was separated, adjusted to pH 1 with concentrated hydrochloric acid and extracted with diisopropyl ether. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was distilled off, and the resulting crude crystal was washed with a small amount of diisopropyl ether and air-dried to obtain 3-iodo-2-{[(lS)-l-methyl-2-(methylthio)ethyl]- carbamoyl} benzoic acid (32.2 g).Melting point: 132 – 134C
28418-88-4, The synthetic route of 28418-88-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAYER CROPSCIENCE AG; WADA, Katsuaki; YONETA, Yasushi; GOMIBUCHI, Takuya; MURATA, Tetsuya; KUDO, Sachio; KISHIKAWA, Hidetoshi; SHIBUYA, Katsuhiko; SHIMOJA, Eiichi; EMOTO, Akira; SATO, Yoshitaka; FISCHER, Ruediger; FUNKE, Christian; ARNOLD, Christian; FRANKEN, Eva-Maria; MALSAM, Olga; SANWALD, Erich; GOeRGENS, Ulrich; ATAKA, Masashi; RECKMANN, Udo; PAULITZ, Christian; KAPFERER, Tobias; WO2010/12442; (2010); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem